Structural and functional brain alterations in anorexia nervosa:A multimodal meta‐analysis of neuroimaging studies

Su, Ting; Gong, Jiaying; Tang, Guixian; Qiu, Shaojuan; Chen, Pan; Chen, Guanmao; Wang, Junjing; Huang, Li; Wang, Ying

doi:10.1002/hbm.25602

Cited by 38 publications

(27 citation statements)

References 114 publications

(119 reference statements)

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“…Longitudinal investigations show restitution of GM and WM volumetric alterations following long-term weight restoration [ 4 ]. Apart from structural brain alterations, also the function of various domains has been reported to be affected in acute AN [ 6 , 7 ], although the involved brain areas differed [ 8 ]. Due to significant loss of weight, cerebral aberrations might be associated with metabolic changes, i.e.…”

Section: Introductionmentioning

confidence: 99%

State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

et al. 2022

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Background The understanding of the cerebral neurobiology of anorexia nervosa (AN) with respect to state- versus trait-related abnormalities is limited. There is evidence of restitution of structural brain alterations with clinical remission. However, with regard to functional brain abnormalities, this issue has not yet been clarified. Methods We compared women with AN (n = 31), well-recovered female participants (REC) (n = 18) and non-patients (NP) (n = 27) cross-sectionally. Functional magnetic resonance imaging was performed to compare neural responses to food versus non-food images. Additionally, affective ratings were assessed. Results Functional responses and affective ratings did not differ between REC and NP, even when applying lenient thresholds for the comparison of neural responses. Comparing REC and AN, the latter showed lower valence and higher arousal ratings for food stimuli, and neural responses differed with lenient thresholds in an occipital region. Conclusions The data are in line with some previous findings and suggest restitution of cerebral function with clinical recovery. Furthermore, affective ratings did not differ from NP. These results need to be verified in intra-individual longitudinal studies.

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Section: Introductionmentioning

confidence: 99%

State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

et al. 2022

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“…On the one hand, as the core area of the visual network (VN), the MOG is mainly responsible for regulating visual function, which is essential for social cognitive function ( Tohid et al, 2015 ). Researchers have shown that deficits in MOG potentially could be associated with body image distortion ( Su et al, 2021 ). Another study revealed that patients with mild cognitive impairment also showed hypoperfusion in the occipital gyrus ( Arslan et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Brain Functional Alterations in Prepubertal Boys With Autism Spectrum Disorders

Yue

Zhang

et al. 2022

Front. Hum. Neurosci.

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ObjectivesAbnormal brain function in ASD patients changes dynamically across developmental stages. However, no one has studied the brain function of prepubertal children with ASD. Prepuberty is an important stage for children’s socialization. This study aimed to investigate alterations in local spontaneous brain activity in prepubertal boys with ASD.Materials and MethodsMeasures of the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) acquired from resting-state functional magnetic resonance imaging (RS-fMRI) database, including 34 boys with ASD and 49 typically developing (TD) boys aged 7 to 10 years, were used to detect regional brain activity. Pearson correlation analyses were conducted on the relationship between abnormal ALFF and ReHo values and Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R) scores.ResultsIn the ASD group, we found decreased ALFF in the left inferior parietal lobule (IPL) and decreased ReHo in the left lingual gyrus (LG), left superior temporal gyrus (STG), left middle occipital gyrus (MOG), and right cuneus (p < 0.05, FDR correction). There were negative correlations between ReHo values in the left LG and left STG and the ADOS social affect score and a negative correlation between ReHo values in the left STG and the calibrated severity total ADOS score.ConclusionBrain regions with functional abnormalities, including the left IPL, left LG, left STG, left MOG, and right cuneus may be crucial in the neuropathology of prepubertal boys with ASD. Furthermore, ReHo abnormalities in the left LG and left STG were correlated with sociality. These results will supplement the study of neural mechanisms in ASD at different developmental stages, and be helpful in exploring the neural mechanisms of prepubertal boys with ASD.

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“…Indeed, lower total brain volume has been observed in rodent models of autism and early-life stress ( Golden et al, 2021 ; Reshetnikov et al, 2021 ). Further, loss of brain volume in specific brain regions is observed in a variety of psychiatric illnesses ( Angelescu et al, 2021 ; Steuber et al, 2021 ; Su et al, 2021 ). Previous studies have shown similar decreases in brain weight in males and female rats, following buprenorphine exposure but these results compared brain weight on postnatal day 21, not in adulthood ( Hung et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Gestational Buprenorphine Exposure Disrupts Dopamine Neuron Activity and Related Behaviors in Adulthood

Elam¹,

Donegan

Hsieh

et al. 2022

eNeuro

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Opioid misuse among pregnant women is rapidly increasing in the United States. The number of maternal opioid-related diagnoses increased by 131% in the last 10 years, resulting in an increased number of infants exposed to opioids in utero and a subsequent increase in infants developing neonatal abstinence syndrome (NAS). The most prescribed treatment to combat maternal opioid use disorder is buprenorphine, a partial μ-opioid receptor agonist and κ-opioid receptor antagonist. Buprenorphine treatment effectively reduces NAS but has been associated with disrupted cortical development and neurodevelopmental consequences in childhood. Less is known about the long-term neurodevelopmental consequences following buprenorphine exposure in utero . Previous research has shown that gestational buprenorphine exposure can induce anxiety-like and depressive-like phenotypes in adult rats, suggesting that exposure to buprenorphine in utero may render individuals more susceptible to psychiatric illness in adulthood. A common pathology observed across multiple psychiatric illnesses is dopamine system dysfunction. Here, we administered the highly-abused opioid, oxycodone (10 mg/kg, i.p.) or a therapeutic used to treat opioid use disorder, buprenorphine (1 mg/kg, i.p) to pregnant Sprague Dawley rats from gestational day 11 through 21, then examined neurophysiological alterations in the mesolimbic dopamine system and dopamine-dependent behaviors in adult offspring. We found that gestational exposure to buprenorphine or oxycodone increases dopamine neuron activity in adulthood. Moreover, prenatal buprenorphine exposure disrupts the afferent regulation of dopamine neuron activity in the ventral tegmental area (VTA). Taken together, we posit that gestational buprenorphine or oxycodone exposure can have profound effects on the mesolimbic dopamine system in adulthood.

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Structural and functional brain alterations in anorexia nervosa:A multimodal meta‐analysis of neuroimaging studies

Cited by 38 publications

References 114 publications

State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

Brain Functional Alterations in Prepubertal Boys With Autism Spectrum Disorders

Gestational Buprenorphine Exposure Disrupts Dopamine Neuron Activity and Related Behaviors in Adulthood

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