Structural and functional brain abnormalities in postherpetic neuralgia: A systematic review of neuroimaging studies

Tang, Yu; Wang, Maohua; Tian, Zheng; Yan, Xin; Wang, Song; Han, Fei; Chen, Guangxiang

doi:10.1016/j.brainres.2020.147219

Cited by 16 publications

(12 citation statements)

References 81 publications

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“…It might result from the long-term disuse of the affected limb (Conboy et al, 2021). In addition, the IPL is a part of the "pain matrix" responsible for pain processing, including discriminating and sensing pain and directing attention to deleterious stimulation and high sensory integration (Nakata et al, 2008;Silvestro et al, 2021;Tang et al, 2021). It further supported the idea that the neuroplasticity related to pain processing occurred in the CAI patient, likely presenting as an inhibitory neural correlation between the painrelated regions, the OFC and the IPL.…”

Section: Discussionmentioning

confidence: 73%

Not Only in Sensorimotor Network: Local and Distant Cerebral Inherent Activity of Chronic Ankle Instability—A Resting-State fMRI Study

Shen

Wang

et al. 2022

Front. Neurosci.

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BackgroundIncreasing evidence has proved that chronic ankle instability (CAI) is highly related to the central nervous system (CNS). However, it is still unclear about the inherent cerebral activity among the CAI patients.PurposeTo investigate the differences of intrinsic functional cerebral activity between the CAI patients and healthy controls (HCs) and further explore its correlation with clinical measurement in CAI patients.Materials and MethodsA total of 25 CAI patients and 39 HCs were enrolled in this study. Resting-state functional magnetic resonance imaging (rs-fMRI) was used to detect spontaneous cerebral activity. The metrics of amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) of the two groups were compared by two-sample t-test. The brain regions that demonstrated altered functional metrics were selected as the regions of interest (ROIs). The functional connectivity (FC) was analyzed based on the ROIs. The Spearman correlation was calculated between rs-fMRI metrics and clinical scale scores.ResultsCompared with HCs, CAI patients showed higher ALFF and ReHo values in the right postcentral gyrus, the right precentral gyrus, and the right middle frontal gyrus, while lower fALFF values in the orbital-frontal cortex (OFC, p < 0.01 after correction). Increasing FC between the right precentral gyrus and the right postcentral gyrus while decreasing FC between the right precentral gyrus and the anterior cingulum cortex (ACC), the right middle frontal gyrus and the left middle temporal gyrus, and the OFC and left inferior parietal lobule (IPL) was observed. In addition, in the CAI group, the ReHo value negatively correlated with the Cumberland Ankle Instability Tool score in the right middle frontal gyrus (r = −0.52, p = 0.007).ConclusionThe CAI patients exhibited enhanced and more coherent regional inherent neuronal activity within the sensorimotor network while lower regional inherent activity in pain/emotion modulation related region. In addition, the information exchanges were stronger within the sensorimotor network while weaker between distant interhemispheric regions. Besides, the increased inherent activity in the right middle frontal gyrus was related to clinical severity. These findings may provide insights into the pathophysiological alteration in CNS among CAI patients.

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Section: Discussionmentioning

confidence: 73%

Not Only in Sensorimotor Network: Local and Distant Cerebral Inherent Activity of Chronic Ankle Instability—A Resting-State fMRI Study

Shen

Wang

et al. 2022

Front. Neurosci.

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“…The pathologic changes of PHN that occur in peripheral nerves and dorsal root ganglia may result in central sensitization. Many neuroimaging studies on HZ and PHN have demonstrated abnormalities in the function and structure of the brain [44,45]. Although the association of skin temperature and central sensitization in patients with PHN has not been reported, excessive vasoconstriction has been observed due to enhanced sympathetic outflow after spinal cord injury [46].…”

Section: Discussionmentioning

confidence: 99%

Determining the Definitive Time Criterion for Postherpetic Neuralgia Using Infrared Thermographic Imaging

Kim

Lee

Han³

et al. 2022

Pain Ther

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Introduction:The time criteria used in many studies of postherpetic neuralgia (PHN) are arbitrary and do not have supporting evidence. Therefore, this study sought to determine the definite time criterion for PHN by analyzing the skin temperature to estimate the time point when zoster-induced skin inflammatory reaction ends. Methods: Infrared thermography was used to measure the difference in skin temperature between the affected and unaffected areas (DTemp) in the craniocervical and thoracic regions of patients with herpes zoster (HZ). Because the DTemp changes from a positive value to zero when the skin is no longer inflamed, a DTemp B 0 was defined as the end of skin inflammation, and this time point was considered the starting point for PHN. This cutoff time point was estimated using receiver operating characteristic (ROC) curve analysis. Results: A total of 503 patients were included in this study. The ROC curve analysis showed that the time point when the DTemp was B 0 occurred at 12 weeks after HZ onset (95% confidence interval 11-15 weeks, area under the ROC curve 0.901). Using this time point as the time criterion of PHN, the sensitivity, specificity, and classification accuracy were 0.807, 0.905, and 0.871, respectively.

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“…According to neurophysiological research, acute herpes zoster will damage the nervous system, causing lesions in the surrounding central nervous system [ 3 ]. So far, the most basic treatment for neuralgia after herpes zoster is drug therapy [ 4 ]. Pregabalin is a new generation of anticonvulsants that can be used to treat chronic pain.…”

Section: Introductionmentioning

confidence: 99%

The Curative Effect of Pregabalin in the Treatment of Postherpetic Neuralgia Analyzed by Deep Learning‐Based Brain Resting‐State Functional Magnetic Resonance Images

Zheng

Lei²,

Bai³

et al. 2022

Contrast Media & Molecular Imaging

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This work aimed to investigate the brain resting-state functional magnetic resonance imaging (fMRI) technology based on the depth autoencoders algorithm and to evaluate the clinically curative effect of pregabalin in the treatment of postherpetic neuralgia (PHN). In this study, 40 patients with PHN were selected and rolled randomly into a treatment group and a control group (20 cases in each group). Then, a depth autoencoders algorithm was constructed and applied in the brain resting-state fMRI technology. The brains of 40 patients with PHN treated with pregabalin were scanned, and the time curve extracted from MRI images was convolved by linear drift removal bandpass filtering to reduce low-frequency drift and high-frequency noise, so the low-frequency amplitude was calculated. Based on the low-frequency amplitude method, the calculated low-frequency signal energy was eventually divided by the total power of the entire frequency band to obtain the low-frequency amplitude rate value. The amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (f-ALFF) before and after treatment were compared between the treatment group and the control group, and the visual analog scale (VAS) after treatment was also observed. After 4 weeks of taking the drug, the VAS scores of patients from the treatment group in the first week (6.5 ± 0.8 points), the second week (6.5 ± 0.8 points), the third week (3.1 ± 0.3 points), and the fourth week (2.3 ± 0.4 points) after treatment were lower steeply than the scores before treatment (8.3 ± 1.1 points) ( P < 0.05 ). Resting-state fMRI images showed that the f-ALFF of the 4 brain areas in the treatment group was higher than that of the control group, mainly including the bilateral frontal lobes, bilateral parietal lobes, left parietal lobes, and right posterior cerebellar lobes. Besides, the f-ALFF of the 6 brain areas in the treatment group was lower than that of the control group, mainly including the right frontal lobe, right parietal lobe, right middle frontal gyrus, precuneus, left frontal lobe, and superior frontal gyrus. In conclusion, the resting-state fMRI technology based on the depth autoencoders algorithm could efficiently display the brain area characteristic changes of patients with PHN before and after treatment, thereby providing a reference for the diagnosis of the patient’s condition.

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Structural and functional brain abnormalities in postherpetic neuralgia: A systematic review of neuroimaging studies

Cited by 16 publications

References 81 publications

Not Only in Sensorimotor Network: Local and Distant Cerebral Inherent Activity of Chronic Ankle Instability—A Resting-State fMRI Study

Not Only in Sensorimotor Network: Local and Distant Cerebral Inherent Activity of Chronic Ankle Instability—A Resting-State fMRI Study

Determining the Definitive Time Criterion for Postherpetic Neuralgia Using Infrared Thermographic Imaging

The Curative Effect of Pregabalin in the Treatment of Postherpetic Neuralgia Analyzed by Deep Learning‐Based Brain Resting‐State Functional Magnetic Resonance Images

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