Junying Zhou, Michelle Richardson, Vidyavathi Reddy, Mani Menon, Evelyn R. Barrack, G. Prem-Veer Reddy, Sahn-Ho Kim
Abstract:Telomeres protect the ends of linear chromosomes from being recognized as damaged DNA, and telomere stability is required for genome stability. Here we demonstrate that telomere stability in androgen receptor (AR)-positive LNCaP human prostate cancer cells is dependent on AR and androgen, as AR inactivation by AR antagonist bicalutamide (Casodex), AR-knockdown, or androgen-depletion caused telomere dysfunction, and the effect of androgen-depletion or Casodex was blocked by the addition of androgen. Notably, ne…
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