2013
DOI: 10.18632/aging.100524
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Abstract: Telomeres protect the ends of linear chromosomes from being recognized as damaged DNA, and telomere stability is required for genome stability. Here we demonstrate that telomere stability in androgen receptor (AR)-positive LNCaP human prostate cancer cells is dependent on AR and androgen, as AR inactivation by AR antagonist bicalutamide (Casodex), AR-knockdown, or androgen-depletion caused telomere dysfunction, and the effect of androgen-depletion or Casodex was blocked by the addition of androgen. Notably, ne… Show more

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Cited by 20 publications
(44 citation statements)
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References 77 publications
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“…Therefore, cells containing immunofluorescent foci of 53BP1 and phosphorylated H2AX (␥H2AX) colocalized with telomeric protein TIN2, which are referred to as telomere-dysfunction induced foci (TIF), were scored as a measure of DNA damage response as described previously (3,4). Individual cells with Ͼ5 53BP1 or ␥H2AX foci were considered as being TIF response-positive.…”
Section: Methodsmentioning
confidence: 99%
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“…Therefore, cells containing immunofluorescent foci of 53BP1 and phosphorylated H2AX (␥H2AX) colocalized with telomeric protein TIN2, which are referred to as telomere-dysfunction induced foci (TIF), were scored as a measure of DNA damage response as described previously (3,4). Individual cells with Ͼ5 53BP1 or ␥H2AX foci were considered as being TIF response-positive.…”
Section: Methodsmentioning
confidence: 99%
“…Therefore, there is an urgent need for novel therapeutic strategies for the treatment of prostate cancer. Our studies point to a novel role of AR in telomere stability (3,4) that may be harnessed to potentiate the efficacy of currently available AR-targeted therapies for a more effective treatment of prostate cancer.…”
mentioning
confidence: 87%
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