Structural and Functional Aspects of Cells in the Nasal Mucociliary System

Petruson, Björn; Hansson, Hans‐Arne; Karlsson, Göran

doi:10.1001/archotol.1984.00800350018006

Cited by 59 publications

(25 citation statements)

References 14 publications

(1 reference statement)

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“…The ultrastructural features of the specimens were recorded and compared with those of the normal nasal mucosa [8][9][10] as well as of the allergic nasal mucosa [3][4][5][6][7], …”

Section: Preparation O F Specimens For Semmentioning

confidence: 99%

Ultrastructural Observations on Vasomotor Rhinitis

Elwany

Bumsted

1987

ORL

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The ultrastructure of the respiratory nasal mucosa of patients suffering from vasomotor rhinitis was studied and compared with the reported ultrastructural findings in cases of chronic perennial allergic rhinitis. The principal ultrastructural differences were the absence of interendothelial gap junctions, the scarcity of eosinophils and plasma cells, and the absence of immunologically stimulated or degranulated mast cells in vasomotor rhinitis. These differences were discussed in the light of the known pathophysiologic facts.

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“…The ultrastructural features of the specimens were recorded and compared with those of the normal nasal mucosa [8][9][10] as well as of the allergic nasal mucosa [3][4][5][6][7], …”

Section: Preparation O F Specimens For Semmentioning

confidence: 99%

Ultrastructural Observations on Vasomotor Rhinitis

Elwany

Bumsted

1987

ORL

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“…as they mature, these elements seem to be involved in the extrusion of large amounts of glycogen, apparently to maintain and increase the previously described coating. This fact, together with well-developed interdigitation and enlarged intercellular spaces, seems to be particularly appropriate since unciliated cells, in the adult respiratory tract, arc believed to play a role in the production and hydroregulation of the mucous layer [18]. Therefore, two different cellular types can apparently be detected since the very early stages of the considered period.…”

Section: Discussionmentioning

confidence: 99%

Morphological Study of Fetal Nasopharyngeal Epithelium in Man

Gulisano

Montella²,

Orlandini³

et al. 1992

Cells Tissues Organs

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In 30 human fetuses between 8 and 13 weeks of intrauterine life the lateral wall of the nasopharynx was examined by light microscopy and transmission am scanning electron microscopy. In the subjects between 8 and 9 weeks in utero the mucosa displays still an immature appearance, being mono- or bistratifiet and lacking the characteristic structures of the respiratory epithelium. Nevertheless, signs of differentiation are to be noticed, with the presence of two distinc cellular types that, in the later periods, will give rise to ciliated cells and microvillus-provided cells. An almost complete differentiation will be reached at 12–13 weeks in utero, even if goblet cells are still lacking in the examined zone during the considered period. Nonrespiratory types of epithelium, such as transitional or squamous, were never found in the studied subjects.

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“…These cells are of importance for the transepithelial fluid flow, thereby of special importance for the regulation of the periciliary fluid [15]. Most antibodies to be released into the mucus are secreted by the submucosal glands, but a deficient epithelial lining of the nasal cavity may impair the immunological protection.…”

Section: Discussionmentioning

confidence: 99%

Morphological Basis for Impaired Protective Efficiency by the Nasal Mucosa in Infants with and without Recurrent Acute Otitis media: A Light and Electron Microscopy Study

Jørgensen

Hansson

1990

Int Arch Allergy Immunol

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The structure of the nasal mucosa in biopsy specimens from the inferior turbinate in ‘normal healthy’ infants (n = 27) was compared with that in age-matched infants (n = 59) with increased frequency of recurrent acute otitis media (RAOM). Light and transmission electron microscopic examination revealed that the healthy infants, i.e., the control subjects, had almost as extensive structural changes in their nasal mucosa as those with RAOM. Only 1 infant in each group was considered to have normal nasal mucosa from a morphological point of view. The high frequencies of structural abnormalities in the nasal mucosa in infants, healthy or with RAOM, is likely to be due to frequent infections causing damage so often and to such high extent that the repair processes became insufficient and thus did not restore the structure of the nasal mucosa. Mucosal lining defects may decrease the resistance to infections, resulting in frequent relapses further adding to the mucosal damage, i.e., a self-ongoing circle.

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Structural and Functional Aspects of Cells in the Nasal Mucociliary System

Cited by 59 publications

References 14 publications

Ultrastructural Observations on Vasomotor Rhinitis

Ultrastructural Observations on Vasomotor Rhinitis

Morphological Study of Fetal Nasopharyngeal Epithelium in Man

Morphological Basis for Impaired Protective Efficiency by the Nasal Mucosa in Infants with and without Recurrent Acute Otitis media: A Light and Electron Microscopy Study

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