Structural and functional alterations in the brains of patients with anisometropic and strabismic amblyopia: a systematic review of magnetic resonance imaging studies

Li, Fēi; Wang, Yuxia; Wu, Ye; Luo, Lekai

doi:10.4103/1673-5374.371349

Cited by 6 publications

(2 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study suggests that children with amblyopia exhibit damage to V1, and there is a correlation between the left middle frontal gyrus, left inferior frontal gyrus, and BA17, hinting at a potential neural mechanism contributing to anisometropic amblyopia. In contrast to prior research [9‒12], our study observed an improved RSFC between the left posterior central gyrus of the anisometropic amblyopia group and BA17. This suggests that individuals can adapt to gather information from their surroundings through multiple sensory channels and senses.…”

Section: Discussioncontrasting

confidence: 99%

“…Abnormal spontaneous activity has been observed in the angular gyrus [9] and cingulate gyrus [10] of amblyopic patients. Wang et al [11] reported that compensations for amblyopia that are reflected in enhanced spontaneous brain function have been reported in the early visual cortices in the resting state, as well as reduced functional connectivity in the dorsal pathway and structural connections in the ventral pathway in both anisometropic amblyopia and strabismic amblyopia patients. Wang et al [12] reported significantly reduced short-term functional connectivity density in the inferior temporal/fusiform gyri, parieto-occipital, and rostrolateral prefrontal cortices of amblyopic children compared to those with normal vision.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Resting-State Functional Connectivity of the Primary Visual Cortex in Children with Anisometropia Amblyopia

Yu,

Zhao,

et al. 2024

Ophthalmic Res

View full text Add to dashboard Cite

Introduction: This study aimed to explore the functional connectivity of the primary visual cortex (V1) in children with anisometropic amblyopia by using the resting-state functional connectivity analysis method and determine whether anisometropic amblyopia is associated with changes in brain function. Methods: Functional magnetic resonance imaging (fMRI) data were obtained from 16 children with anisometropia amblyopia (CAA group) and 12 healthy children (HC group) during the resting state. The Brodmann area 17 (BA17) was used as the region of interest, and the functional connection (FC) of V1 was analyzed in both groups. A two-sample t test was used to analyze the FC value between the two groups. Pearson’s correlation was used to analyze the correlation between the mean FC value in the brain function change area of the CAA group and the best corrected visual acuity (BCVA) of amblyopia. p < 0.05 was considered statistically significant. Results: There were no significant differences in age and sex between the CAA and HC groups (p > 0.05). Compared to the HC group, the CAA group showed lower FC values in BA17 and the left medial frontal gyrus, as well as BA17 and the left triangle inferior frontal gyrus. Conversely, the CAA group showed higher FC values in BA17 and the left central posterior gyrus. Notably, BCVA in amblyopia did not correlate with the area of change in mean FC in the brain function of the CAA group. Conclusion: Resting-state fMRI-based functional connectivity analysis indicates a significant alteration in V1 of children with anisometropic amblyopia. These findings contribute additional insights into the neuropathological mechanisms underlying visual impairment in anisometropic amblyopia.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resting-State Functional Connectivity of the Primary Visual Cortex in Children with Anisometropia Amblyopia

Yu,

Zhao,

et al. 2024

Ophthalmic Res

View full text Add to dashboard Cite

show abstract

Differential cortical gray matter changes in early- and late-onset patients with amyotrophic lateral sclerosis

Ai,

Li,

Hou

et al. 2023

Cerebral Cortex

View full text Add to dashboard Cite

Age at onset may be an important feature associated with distinct subtypes of amyotrophic lateral sclerosis (ALS). Little is known about the neuropathological mechanism of early-onset ALS (EO-ALS) and late-onset ALS (LO-ALS). Ninety ALS patients were divided into EO-ALS and LO-ALS group, and 128 healthy controls were matched into young controls(YCs) and old controls (OCs). A voxel-based morphometry approach was employed to investigate differences in gray matter volume (GMV). Significant age at onset-by-diagnosis interactions were found in the left parietal operculum, left precentral gyrus, bilateral postcentral gyrus, right occipital gyrus, and right orbitofrontal cortex. Post hoc analysis revealed a significant decrease in GMV in all affected regions of EO-ALS patients compared with YCs, with increased GMV in 5 of the 6 brain regions, except for the right orbitofrontal cortex, in LO-ALS patients compared with OCs. LO-ALS patients had a significantly increased GMV than EO-ALS patients after removing the aging effect. Correspondingly, GMV of the left postcentral gyrus correlated with disease severity in the 2 ALS groups. Our findings suggested that the pathological mechanisms in ALS patients with different ages at onset might differ. These findings provide unique insight into the clinical and biological heterogeneity of the 2 ALS subtypes.

show abstract

Shared and differing functional connectivity abnormalities of the default mode network in mild cognitive impairment and Alzheimer’s disease

Wang,

Li,

Yao

et al. 2024

Cerebral Cortex

View full text Add to dashboard Cite

Alzheimer’s disease (AD) and mild cognitive impairment (MCI) both show abnormal resting-state functional connectivity (rsFC) of default mode network (DMN), but it is unclear to what extent these abnormalities are shared. Therefore, we performed a comprehensive meta-analysis, including 31 MCI studies and 20 AD studies. MCI patients, compared to controls, showed decreased within-DMN rsFC in bilateral medial prefrontal cortex/anterior cingulate cortex (mPFC/ACC), precuneus/posterior cingulate cortex (PCC), right temporal lobes, and left angular gyrus and increased rsFC between DMN and left inferior temporal gyrus. AD patients, compared to controls, showed decreased rsFC within DMN in bilateral mPFC/ACC and precuneus/PCC and between DMN and left inferior occipital gyrus and increased rsFC between DMN and right dorsolateral prefrontal cortex. Conjunction analysis showed shared decreased rsFC in mPFC/ACC and precuneus/PCC. Compared to MCI, AD had decreased rsFC in left precuneus/PCC and between DMN and left inferior occipital gyrus and increased rsFC in right temporal lobes. MCI and AD share a decreased within-DMN rsFC likely underpinning episodic memory deficits and neuropsychiatric symptoms, but differ in DMN rsFC alterations likely related to impairments in other cognitive domains such as language, vision, and execution. This may throw light on neuropathological mechanisms in these two stages of dementia.

show abstract

Structural and functional alterations in the brains of patients with anisometropic and strabismic amblyopia: a systematic review of magnetic resonance imaging studies

Cited by 6 publications

References 112 publications

Resting-State Functional Connectivity of the Primary Visual Cortex in Children with Anisometropia Amblyopia

Resting-State Functional Connectivity of the Primary Visual Cortex in Children with Anisometropia Amblyopia

Differential cortical gray matter changes in early- and late-onset patients with amyotrophic lateral sclerosis

Shared and differing functional connectivity abnormalities of the default mode network in mild cognitive impairment and Alzheimer’s disease

Contact Info

Product

Resources

About