Structural and Functional Abnormities of Amygdala and Prefrontal Cortex in Major Depressive Disorder With Suicide Attempts

Wang, Lifei; Zhao, Yimeng; Edmiston, E. Kale; Womer, Fay Y.; Zhang, Ran; Zhao, Pengfei; Jiang, Xiaowei; Wu, Feng; Kong, Liang; Zhou, Yifang; Tang, Yanqing; Wei, Shengnan

doi:10.3389/fpsyt.2019.00923

Cited by 47 publications

(31 citation statements)

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“…Study of Wang et al found that MDD patients with a history of SA had a reduced volume in the right and left amygdala and ventral, medial, dorsal PFC. These demonstrate the role of the amygdala and PFC in the pathogenesis of suicidal behavior and imply the amygdala-PFC circuit as a probable target for detection and prevention of suicidal behaviors [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Volumetric MRI Analysis of Brain Structures in Patients with History of First and Repeated Suicide Attempts: A Cross Sectional Study

et al. 2021

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Structural brain changes are found in suicide attempters and in patients with mental disorders. It remains unclear whether the suicidal behaviors are related to atrophy of brain regions and how the morphology of specific brain areas is changing with each suicide attempt. The sample consisted of 56 patients hospitalized after first suicide attempt (first SA) (n = 29), more than one suicide attempt (SA > 1) (n = 27) and 54 healthy controls (HC). Brain volume was measured using FreeSurfer 6.0 automatic segmentation technique. In comparison to HC, patients with first SA had significantly lower cortical thickness of the superior and rostral middle frontal areas, the inferior, middle and superior temporal areas of the left hemisphere and superior frontal area of the right hemisphere. In comparison to HC, patients after SA > 1 had a significantly lower cortical thickness in ten areas of frontal cortex of the left hemisphere and seven areas of the right hemisphere. The comparison of hippocampus volume showed a significantly lower mean volume of left and right parts in patients with SA > 1, but not in patients with first SA. The atrophy of frontal, temporal cortex and hippocampus parts was significantly higher in repeated suicide attempters than in patients with first suicide attempt.

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Section: Discussionmentioning

confidence: 99%

Volumetric MRI Analysis of Brain Structures in Patients with History of First and Repeated Suicide Attempts: A Cross Sectional Study

et al. 2021

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“…In people diagnosed with BP who have attempted suicide, decreased FA has been observed in the fronto-occipital fasciculus, uncinate fasciculus, corpus callosum, internal and external capsule, corona radiata, and the thalamic radiations in comparison to those who have not attempted suicide. The presence of similar changes within the brain may indicate a common pathomechanism in these affective disorders [ 73 ]. Table 4 presents, inter alia, disturbances in diffusion parameters in various fiber bundles in affective disorders.…”

Section: Changes In White Matter In Affective Diseasesmentioning

confidence: 99%

Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis

et al. 2020

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Diffusion tensor imaging (DTI) is an imaging technique that uses magnetic resonance. It measures the diffusion of water molecules in tissues, which can occur either without restriction (i.e., in an isotropic manner) or limited by some obstacles, such as cell membranes (i.e., in an anisotropic manner). Diffusion is most often measured in terms of, inter alia, fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). DTI allows us to reconstruct, visualize, and evaluate certain qualities of white matter. To date, many studies have sought to associate various changes in the distribution of diffusion within the brain with mental diseases and disorders. A better understanding of white matter integrity disorders can help us recognize the causes of diseases, as well as help create objective methods of psychiatric diagnosis, identify biomarkers of mental illness, and improve pharmacotherapy. The aim of this work is to present the characteristics of DTI as well as current research on its use in schizophrenia, affective disorders, and other mental disorders.

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Section: Discussionmentioning

confidence: 72%

Volumetric MRI analysis of brain structures in patients with history of first and repeated suicide attempts: a cross sectional study

Sarkinaite

Gleiznienė

Adomaitienė

et al. 2020

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Background Structural brain changes are found in suicide attempters, as well as in patients with mental disorders. It remains unclear whether the suicidal behavior is related to atrophy of brain regions and how the morphology of specific brain areas is changing with each suicide attempt. This cross-sectional study examined volumetric differences in brain regions among patients with history of first and repeated suicide attempts in comparison to healthy controls (HC). Methods The sample consisted of 56 adults, non-psychotic patients without cognitive impairment and any organic brain disorders hospitalized after first suicide attempt (first SA) (n=29) and more than one suicide attempt (SA>1) during the lifetime (n=27); and 54 adult volunteers without history of mental disorder and suicide attempts, designated as HC. The MRI data were collected using 1.5 T Siemens Avanto scanner. Brain cortical thickness, grey and white matter volumes were measured using FreeSurfer 6.0 automatic segmentation technique. Results In comparison to HC, patients with first SA had 3.5, 3.58 and 4.19% significantly lower mean cortical thickness of the superior and rostral middle frontal areas of the left hemisphere and superior frontal area of the right hemisphere, respectively; 4.09, 4.02 and 4.49% lower mean cortical thickness of the inferior, middle and superior temporal areas of the left hemisphere, respectively. In comparison to HC, patients after SA>1 had a significantly lower mean cortical thickness (from 4.02 to 8.33%) in ten areas of frontal cortex of the left hemisphere and seven areas of the right hemisphere; from 3.90 to 6.04% difference in six areas of temporal cortex in both hemispheres. The comparison of hippocampus volume showed a significantly lower mean volume (7.86 to 9.89%) of left and right parts in patients with SA>1, but not in patients with first SA. Conclusions Hospitalized suicide attempters had lower frontal and temporal cortical thickness and smaller parts of hippocampus than HC; these differences were significantly higher in repeated suicide attempters than in patients with first SA. Our findings suggest that repeated suicidal behavior is associated with intensifying atrophy of specific brain structures, independently of diagnosis of depressive disorders.

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Structural and Functional Abnormities of Amygdala and Prefrontal Cortex in Major Depressive Disorder With Suicide Attempts

Cited by 47 publications

References 56 publications

Volumetric MRI Analysis of Brain Structures in Patients with History of First and Repeated Suicide Attempts: A Cross Sectional Study

Volumetric MRI Analysis of Brain Structures in Patients with History of First and Repeated Suicide Attempts: A Cross Sectional Study

Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis

Volumetric MRI analysis of brain structures in patients with history of first and repeated suicide attempts: a cross sectional study

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