Structural and Functional Abnormalities of Carotid Artery and Their Relation with EVA Phenomenon

Maloberti, Alessandro; Meani, Paolo; Varrenti, Marisa; Giupponi, Luca; Stucchi, Miriam; Vallerio, Paola; Giannattasio, Cristina

doi:10.1007/s40292-015-0100-9

Cited by 23 publications

(19 citation statements)

References 38 publications

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“…Several studies and meta-analysis have supported this premise, evidencing that cIMT increases cardiovascular risk prediction beyond established risk algorithms, as well as it presents a modest risk reclassification power [49][50][51]; in one other meta-analysis however, the added value of measuring cIMT above the Framingham risk score was minor and precluded its clinical use [52]. However, the inclusion of this biomarker in the identification of EVA subjects has already spurred interest in the scientific community [53], and the fact that recent European reference values of cIMT, obtained with high resolution echo-tracking, have been published is obviously a facilitator of its transition to clinical use [54]. Results from the CARDIA, the Amsterdam Growth and Health Longitudinal and the Bogalusa studies are seriously encouraging in this domain as they evidence a correlation of early exposure to cardiovascular risk factors and concurrent changes in cIMT [55,56], as well as development of cognitive dysfunction [57].…”

Section: Current Methods Used To Identify Eva Subjectsmentioning

confidence: 97%

Early Vascular Ageing (EVA): Definitions and Clinical Applicability

Cunha¹,

Boutouyrie

Nilsson

et al. 2017

CHYR

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Arterial stiffness has been accumulating evidence as an intermediate cardiovascular endpoint. It has been established as an independent risk marker for cardiovascular disease, and reflects the dissociation between chronologic and biologic age of large arteries-attributing earlier the risk that a normal vascular ageing process had installed to occur several years later. The concept of Early Vascular Ageing (EVA) is developed to establish primordial prevention, identifying individuals whose ageing path has been accelerated either by inherent features, interaction with the environment or arterial exposure to several types of insults that evolve to medial layer morphological changes. Understanding the pathophysiology of vascular ageing, its consequences and therapeutic opportunities is therefore an advantage that could be translated in time of prevention and survival free of cardiovascular disease. As the EVA construct is advancing, new features appear as interesting to better translate it into clinical practice.

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Section: Current Methods Used To Identify Eva Subjectsmentioning

confidence: 97%

Early Vascular Ageing (EVA): Definitions and Clinical Applicability

Cunha¹,

Boutouyrie

Nilsson

et al. 2017

CHYR

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“…CCA-IMT was measured in a subgroup of 175 individuals (85 in the upper and 90 in the lower PWV tertiles). With the subject supine and the neck in partial extension, right CCA was scanned by the Philips Sonos 5500 ultrasonography device [ 18 ]. Two-dimensional echocardiograms were performed by an experienced cardiologist using a dedicated ultrasound machine (SONOS 5500; Philips Healthcare, MA, USA with an ultrasound transducer of 2.5MHz.).…”

Section: Methodsmentioning

confidence: 99%

Iron Stores, Hepcidin, and Aortic Stiffness in Individuals with Hypertension

et al. 2015

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Background & AimsIron accumulation within the arterial wall has been hypothesized to promote atherosclerosis progression. Aim of this study was to evaluate whether the hormone hepcidin and iron stores are associated with arterial stiffness in subjects with essential hypertension.MethodsCirculating hepcidin, ferritin, and mutations in the hemochromatosis gene were compared between subjects included in the first vs. third tertile (n=284 each) of carotid-femoral pulse wave velocity (PWV) in an unselected cohort of patients with arterial hypertension.ResultsAt univariate logistic regression analysis, high PWV was associated with higher ferritin levels (p=0.010), but lower hepcidin (p=0.045), and hepcidin ferritin/ratio (p<0.001). Hemochromatosis mutations predisposing to iron overload were associated with high PWV (p=0.025). At multivariate logistic regression analysis, high aortic stiffness was associated with older age, male sex, lower BMI, higher systolic blood pressure and heart rate, hyperferritinemia (OR 2.05, 95% c.i. 1.11-3.17 per log ng/ml; p=0.022), and lower circulating hepcidin concentration (OR 0.29, 95% c.i. 0.16-0.51 per log ng/ml; p<0.001). In subgroup analyses, high PWV was associated with indices of target organ damage, including micro-albuminuria (n=125, p=0.038), lower ejection fraction (n=175, p=0.031), cardiac diastolic dysfunction (p=0.004), and lower S wave peak systolic velocity (p<0.001). Ferritin was associated with cardiac diastolic dysfunction, independently of confounders (p=0.006).ConclusionsIn conclusion, hyperferritinemia is associated with high aortic stiffness and cardiac diastolic dysfunction, while low circulating hepcidin with high aortic stiffness.

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“…While studies comparing ART.LAB and video analysis have been published [10], data regarding the agreement between ART.LAB and other techniques remain scarce. Better assessment of the agreement between measurement methods of IMT (especially WTS and ART.LAB) along with their reproducibility would be helpful before proceeding to collaborative efforts [15]. Good agreement and reproducibility are indeed typically the two requirements of data-merging.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility in Echotracking Assessment of Local Carotid Stiffness, Diameter and Thickness in a Population-based Study (The STANISLAS Cohort Study)

Bozec¹,

Girerd²,

Ferreira³

et al. 2020

Artery Res

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Background: Carotid Intima Media Thickness (IMT) and stiffness are associated with cardiovascular events. The study aims were to perform a head-to-head comparison of the Wall Track System (WTS) and ART.LAB for carotid IMT, distension and diameter echotracking measurements as well as inter-and intra-observer reproducibility. Methods: Echotracking measurements were performed with WTS and ART.LAB in 188 participants from the STANISLAS Cohort (mean age 47 ± 14 years). Inter-observer reproducibility analysis was performed in 60 patients consecutively included among the STANISLAS Cohort and two other ongoing cohorts, in whom measurements were successively performed by three operators. Results: The relative differences between WTS and ART.LAB in artery diameter measurements were minimal (mean difference −1.8%) while the differences in IMT and distension measurements were 6.1% and 4.3%, respectively. The Bland and Altman plots for diameter, distension and intima media thickness showed no measurement bias between ART.LAB and WTS. The internal reproducibility for carotid diameter was good with the two devices (≈2% SD). The ART.LAB performed ≈2-fold better than WTS for IMT internal reproducibility (5% vs. 12.5%, p < 0.0001) and distension internal reproducibility (6.3% vs. 12.4%, p < 0.0001). The inter-and intra-observer reproducibility for carotid diameter and IMT was good for both devices. Complete results were obtained in 1:50 min in ART.LAB and 11:13 min with WTS. Conclusion: ART.LAB and WTS show good agreement, with good inter-and intra-observer reproducibility with the two devices. Nevertheless, internal reproducibility of ART.LAB is better and measurements are easier to perform, favouring this device for carotid intima media thickness and stiffness measurements. H I G H L I G H T S • Our results show a good agreement between ART.LAB and WTS echotracking devices. • In our hands, internal reproducibility of ART.LAB is better than WTS. • Carotid stiffness and thickness measurements are easier/quicker with ART.LAB than with WTS.

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Structural and Functional Abnormalities of Carotid Artery and Their Relation with EVA Phenomenon

Cited by 23 publications

References 38 publications

Early Vascular Ageing (EVA): Definitions and Clinical Applicability

Early Vascular Ageing (EVA): Definitions and Clinical Applicability

Iron Stores, Hepcidin, and Aortic Stiffness in Individuals with Hypertension

Reproducibility in Echotracking Assessment of Local Carotid Stiffness, Diameter and Thickness in a Population-based Study (The STANISLAS Cohort Study)

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