Structural and functional 3D mapping of skin tumours with non‐invasive multispectral optoacoustic tomography

Abstract

Our findings confirm the potential benefit of the new imaging method in guiding surgical intervention to achieve a more precise excision with better clearance and lower relapse rates. It can also potentially help to shorten the duration of Mohs' micrographic surgery. Further large-scale studies are necessary to ensure correlation between MSOT and histology.

Novel Optical Techniques for Imaging Microcirculation in the Diabetic Foot

“…They were able to successfully use PAI to detect the tumor depth in vivo till a depth of 3.75mm in nude mice. In a later study of Chuah et al [85] similar results were found when they performed PAI measurements on three patients with skins tumors. They used PAI to acquire a 3D image of the skin tumors and compared those measurements with histological measurements.…”

Use of 3D Technology to Support Dermatologists Returning to Practice Amid COVID-19

“…Multispectral optoacoustic tomography is a noninvasive imaging tool that can map skin tumors via optical contrast with accuracy comparable to histologic measurements. 5 3-Dimensional facial imaging and printing can be used to calculate tumor surface area for customized masks, leaving sufficient skin for excision and reconstruction. Patient face coverings would cover the nose and mouth, only expose relevant areas near the excision site, and include adjustable/removable ear loops for tumors localized to the ears.…”

Characterization of a Fiber Bundle-Based Real-Time Ultrasound/Photoacoustic Imaging System and Its In Vivo Functional Imaging Applications

“…Both the jacket and holder were designed using the computer-aided design (CAD) software package SolidWorks 2015 (Dassault Systemes S.A., Waltham, MA, USA) and fabricated using a 3-D printer (ProJet 3500, 3D Systems, Inc., Rock Hill, SC, USA) with an accuracy of 0.016 mm. The incident angle of the fiber was optimized to 41 • using the method from a previous study [17] to achieve coplanar light delivery and acoustic detection. The incident energy density on the imaging sample surface was estimated to be approximately 12 mJ/cm 2 , which is much lower than the American National Standards Institute (ANSI) safety limit (20 mJ/cm 2 ) [18].…”