Structural and dynamic consequences of inosine, 2′-O-methylation, and N6-methyladenosine modifications in RNA G-quadruplex: A molecular dynamics study
Nivedita Dutta,
Indrajit Deb,
Joanna Sarzynska
et al.
Abstract:RNA G-quadruplexes (rG4) are stable non-canonical structures, often found to regulate important biological processes such as transcription, translation, splicing, RNA localization, and other steps in gene expression. rG4 structures can also influence DNA-related processes e.g. DNA replication, telomere elongation and homeostasis, and recombination. Due to the involvement of rG4s in such important processes, these structures are potential therapeutic targets against different diseases e.g., viral infection and … Show more
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