Structural Analysis of the Rabbit Kidney

Kaissling, Brigitte; Kriz, Wilhelm

doi:10.1007/978-3-642-67147-0

Cited by 271 publications

(325 citation statements)

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“…9 There was no detectable fat accumulation by extraction procedures within the renal parenchyma, but rather within the renal sinus. The renal sinus is the renal structure that starts from the hilum and intrudes upon the renal parenchyma, yet is physically separated from it by a reflection of the external capsule, 58 as shown in the schematic diagram of Figure 4. Within this space, loose connective tissue surrounds renal blood and lymphatic vessels as well as the ureter.…”

Section: Ectopic Fat Storage In the Kidneymentioning

confidence: 99%

Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

et al. 2004

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In humans and most animal models, the development of obesity leads not only to increased fat depots in classical adipose tissue locations but also to significant lipid deposits within and around other tissues and organs, a phenomenon known as ectopic fat storage. The purpose of this review is to explore the possible locations of ectopic fat in key target-organs of cardiovascular control (heart, blood vessels and kidneys) and to propose how ectopic fat storage can play a role in the pathogenesis of cardiovascular diseases associated with obesity. In animals fed a high-fat diet, cardiac fat depots within and around the heart impair both systolic and diastolic functions, and may in the long-term promote heart failure. Accumulation of fat around blood vessels (perivascular fat) may affect vascular function in a paracrine manner, as perivascular fat cells secrete vascular relaxing factors, proatherogenic cytokines and smooth muscle cell growth factors. Furthermore, high amounts of perivascular fat could mechanically contribute to the increased vascular stiffness seen in obesity. Finally, accumulation of fat in the renal sinus may limit the outflow of blood and lymph from the kidney, which would alter intrarenal physical forces and promote sodium reabsorption and arterial hypertension. Taken together, ectopic fat storage in key target-organs of cardiovascular control may impair their functions, contributing to the increased prevalence of cardiovascular diseases in obese subjects.

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Section: Ectopic Fat Storage In the Kidneymentioning

confidence: 99%

Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

et al. 2004

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“…[26,28,36,54]. Crucially, important work on the general structure of the mammalian kidney was done together with Hermann Koepsell, who later became chair of the department of anatomy in Würzburg, and long-standing collaborator and congenial morphologist Brigitte Kaissling, who left Heidelberg in 1982 for stays in Yale, Basel, and her final destination of Zurich.…”

Section: Architecture Of the Kidneymentioning

confidence: 99%

“…Crucially, important work on the general structure of the mammalian kidney was done together with Hermann Koepsell, who later became chair of the department of anatomy in Würzburg, and long-standing collaborator and congenial morphologist Brigitte Kaissling, who left Heidelberg in 1982 for stays in Yale, Basel, and her final destination of Zurich. Kaissling and Kriz's essential and ground-breaking analysis of the structure of the rabbit kidney contributed essentially to the fine structural definition of renal cell types of the three major compartments of the mammalian kidney, the vasculature, the nephron, and the interstitium [28].…”

Section: Architecture Of the Kidneymentioning

confidence: 99%

“…Based on Kaissling and Kriz's seminal analysis of the structure of the rabbit kidney [28], and in parallel to studies on the medullary organization, Kriz started to work on the structure of the renal tubule together with Brigitte Kaissling, Sebastian Bachmann, and others; rapid progress was achieved along with parallel work from the laboratories of Arvid Maunsbach and Craig Tisher in Aarhus and Florida, respectively, as well as a few other, more functionally oriented pioneers [2,4,27,29]. Here, Kriz, together with Kaissling, Bachmann, Will Minuth, and Werner Franke from Deutsches Krebsforschungszentrum in Heidelberg (DKFZ), elucidated the multiplicity of structures of various tubular segments and entered the field of immunohistochemical identification of specific proteins and their segmental distribution, likely inspired by the beautiful work of Dennis Brown at Harvard.…”

Section: Structure Of the Renal Tubulementioning

confidence: 99%

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From tubular sublimate nephropathy via urinary concentrating mechanism to glomerular disease—Wilhelm Kriz’s contribution to modern nephrology

Bachmann

2017

Pflugers Arch - Eur J Physiol

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“…This area appears gray in the light microscope and contains multiple dividing cells, which cause the elongation of the CD tubule during the dichotomous branching process. Zone 3 comprises the shaft of the ampulla and is recognized by the primary appearance of principal (P) and various types of intercalated (IC) cells (9,11,12).…”

mentioning

confidence: 99%

Urea Restrains Aldosterone-Induced Development of Peanut Agglutinin–Binding on Embryonic Renal Collecting Duct Epithelia

Schumacher¹,

Strehl²,

Minuth³

2003

Journal of the American Society of Nephrology

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Abstract. Peanut agglutinin (PNA) represents a commonly used marker for ␤-type intercalated (IC) cells and their distribution in the corticomedullary course of the collecting duct (CD) in the mature rabbit kidney. It has been shown that aldosterone is able to generate Ͼ90% of PNA-binding cells in an embryonic CD epithelium in vitro. In adult kidney, a maximum of only 25% PNA-positive cells is found in the cortical segment of the CD, and PNA-binding completely disappears in the inner-medullary CD. Molecules that regulate the gradual development of CD-specific cells during organ growth are unknown. In the present experiments, it was found that addition of physiologic concentrations of urea to the culture medium is able to restrain the action of aldosterone in embryonic CD epithelia. Urea antagonizes in a concentration-dependent manner the action of aldosterone finally leading to only 10% of PNA-binding cells. The data point to a urea-specific effect, because osmolytes such as NaCl and mannitol did not affect PNA binding. In addition, urea did not influence expression of principal-cell typical markers such as AQP2 and 3. The findings may explain that a higher number of PNA-positive cells is found in the cortical region of the kidney correlated with a low concentration of urea as compared with only few PNA-binding cells in the medullary CD, where a high concentration of urea occurs. Thus, an increasing concentration of urea may trigger the number of PNA-positive cells in the cortical-medullary course of the CD during organ development.

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Structural Analysis of the Rabbit Kidney

Cited by 271 publications

References 0 publications

Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

From tubular sublimate nephropathy via urinary concentrating mechanism to glomerular disease—Wilhelm Kriz’s contribution to modern nephrology

Urea Restrains Aldosterone-Induced Development of Peanut Agglutinin–Binding on Embryonic Renal Collecting Duct Epithelia

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