Structural Analysis of Nanoparticles Formed via Laser Ablation of Porous Silicon and Silicon Microparticles in Water

Zabotnov, S. V.; Kolchin, A. V.; Kashaev, F. V.; Skobelkina, A. V.; Nesterov, V. Yu.; Presnov, D. E.; Golovan, L. A.; Кашкаров, П. К.

doi:10.1134/s1063785019110142

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…In simulations, we considered the SiNPS obtained via the ablation of SiNW arrays by picosecond laser at wavelength of 1064 nm in water and ethanol (wSiNPs and eSiNPs, correspondingly) and reported in our earlier work [44]. According to previous studies of similar laser-ablated SiNPs, they may have a thin oxide shell [36,60] as well as a small fraction of amorphous phase [61]. Besides, eSiNPs undergo surface carbonization due to high power laser action to ethanol [36].…”

Section: Optical Characteristics Of Sinps Employed In the Simulationsmentioning

confidence: 99%

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

et al. 2021

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Biodegradable and low-toxic silicon nanoparticles (SiNPs) have potential in different biomedical applications. Previous experimental studies revealed the efficiency of some types of SiNPs in tumor hyperthermia. To analyse the feasibility of employing SiNPs produced by the laser ablation of silicon nanowire arrays in water and ethanol as agents for laser tumor hyperthermia, we numerically simulated effects of heating a millimeter-size nodal basal-cell carcinoma with embedded nanoparticles by continuous-wave laser radiation at 633 nm. Based on scanning electron microscopy data for the synthesized SiNPs size distributions, we used Mie theory to calculate their optical properties and carried out Monte Carlo simulations of light absorption inside the tumor, with and without the embedded nanoparticles, followed by an evaluation of local temperature increase based on the bioheat transfer equation. Given the same mass concentration, SiNPs obtained by the laser ablation of silicon nanowires in ethanol (eSiNPs) are characterized by smaller absorption and scattering coefficients compared to those synthesized in water (wSiNPs). In contrast, wSiNPs embedded in the tumor provide a lower overall temperature increase than eSiNPs due to the effect of shielding the laser irradiation by the highly absorbing wSiNPs-containing region at the top of the tumor. Effective tumor hyperthermia (temperature increase above 42 °C) can be performed with eSiNPs at nanoparticle mass concentrations of 3 mg/mL and higher, provided that the neighboring healthy tissues remain underheated at the applied irradiation power. The use of a laser beam with the diameter fitting the size of the tumor allows to obtain a higher temperature contrast between the tumor and surrounding normal tissues compared to the case when the beam diameter exceeds the tumor size at the comparable power.

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Section: Optical Characteristics Of Sinps Employed In the Simulationsmentioning

confidence: 99%

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

et al. 2021

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Laser fragmentation of silicon microparticles in liquids for solution of biophotonics problems

Nesterov¹,

Sokolovskaya²,

Golovan³

et al. 2022

Quantum Electron.

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The possibility of manufacturing silicon nanoparticles by picosecond laser fragmentation of silicon microparticles in water is analysed. It is shown that for fragmentation duration of 40 min, the dependence of the average sizes of particles on the initial mass concentration of the micropowder varied in the range of 0.5–12 mg mL-1 is nonmonotonic, with the maximum average size of 165 nm being achieved at a concentration of 5 mg mL-1. To explain the obtained result, the simulation of propagation of a focused laser beam in a scattering suspension of silicon microparticles is performed for their different mass concentrations. It is demonstrated that at concentrations not exceeding 5 mg mL-1, fragmentation occurs in the paraxial region of the beam when it propagates deep into the cuvette with a suspension, while at higher concentrations it occurs primarily in the superficial layer owing to strong extinction. Calculations results allow the experimental features of the formation of silicon nanoparticles to be explained. Spectrophotometry measurements on suspensions of nanoparticles obtained at the initial concentration of microparticles of 12 mg mL-1 are compared with the theoretical estimates of the absorption and scattering coefficients obtained in the framework of the Mie theory. Measured optical properties indicate the potential of using fragmented nanoparticles as scattering and/or absorbing contrast agents in optical imaging of biological objects.

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Numerical simulation of picosecond laser fragmentation of silicon micropowder in the framework of photothermal mechanism

Sokolovskaya

Golovan

Zabotnov

et al. 2022

Computational Biophysics and Nanobiophotonics

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Structural Analysis of Nanoparticles Formed via Laser Ablation of Porous Silicon and Silicon Microparticles in Water

Cited by 4 publications

References 12 publications

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

Laser fragmentation of silicon microparticles in liquids for solution of biophotonics problems

Numerical simulation of picosecond laser fragmentation of silicon micropowder in the framework of photothermal mechanism

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