Structural Analysis of Ciprofloxacin-Carbopol Polymeric Composites by X-Ray Diffraction and Fourier Transform Infra-Red Spectroscopy

Sahoo, Subhashree; Chakraborti, C K; Naik, S; Mishra, Satish; Nanda, U N

doi:10.4314/tjpr.v10i3.14

Cited by 26 publications

(17 citation statements)

References 15 publications

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“…The absorption band at ∼1478 cm −1 was due to CH 2 bending vibrations (41). An absorption peak at ∼1165 cm −1 represented in-plane bending of the aromatic C-H bonds (42). The absorption band at ∼717 cm −1 was due to the out-of-plane rocking vibrations due to -(CH 2 ) n -groups (39).…”

Section: Molecular Propertiesmentioning

confidence: 98%

Development and Characterization of Sorbitan Monostearate and Sesame Oil-Based Organogels for Topical Delivery of Antimicrobials

et al. 2014

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The current study explains the development of sorbitan monostearate and sesame oil-based organogels for topical drug delivery. The organogels were prepared by dissolving sorbitan monostearate in sesame oil (70°C). Metronidazole was used as a model antimicrobial. The formulations were characterized using phase contrast microscopy, infrared spectroscopy, viscosity, mechanical test, and differential scanning calorimetry. Phase contrast microscopy showed the presence of needle-shaped crystals in the organogel matrix. The length of the crystals increased with the increase in the sorbitan monostearate concentration. XRD studies confirmed the amorphous nature of the organogels. Viscosity study demonstrated shear thinning behavior of the organogels. The viscosity and the mechanical properties of the organogels increased linearly with the increase in the sorbitan monostearate concentration. Stress relaxation study confirmed the viscoelastic nature of the organogels. The organogels were biocompatible. Metronidazole-loaded organogels were examined for their controlled release applications. The release of the drug followed zero-order release kinetics. The drug-loaded organogels showed almost similar antimicrobial activity against Escherichia coli when compared to the commercially available Metrogyl® gel. In gist, it can be proposed that the developed organogels had sufficient properties to be used for controlled delivery of drugs.

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Section: Molecular Propertiesmentioning

confidence: 98%

Development and Characterization of Sorbitan Monostearate and Sesame Oil-Based Organogels for Topical Delivery of Antimicrobials

et al. 2014

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“…The bands at the 1450–1400 cm −1 represented CO and the ones at 1300–1250 cm −1 suggested bending vibration of OH group, which indicated the presence of carboxylic acid. It was reported that, a strong absorption peak between 1050 and 1000 cm −1 was assigned to CF group . It was observed from Figure that spectra “a” of the SA/LS blend band shows characteristic peaks at 1600 and 3500 cm −1 due to the aromatic structure and hydroxyl groups due to LS present in the blend.…”

Section: Resultsmentioning

confidence: 86%

Controlled drug delivery studies of biological macromolecules: Sodium alginate and lignosulphonic acid films

Reddy

Pandit

2014

J of Applied Polymer Sci

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The ciprofloxacin (CPX)-loaded blends made of sodium alginate and lignosulfonic acid (LS) were prepared by solution casting method in the ratio of 80/20. The blends were crosslinked for different intervals of time to control the drug release. The drug release was investigated for 24 hours in different pH medium (1, 4, 7, and 9). It was confirmed that drug release is controlled by diffusion through the polymer matrix followed by the erosion of the polymer. The pH of the surrounding medium influences the drug solubility, swelling, and degradation rate of the polymer and therefore the overall drug release process. The blend shows minimal drug release at pH 1 and 9, whereas moderate release at pH 4, but rapid release at pH 7. Further FTIR, XRD, and SEM characterization are carried, to confirm the chemical-interaction, crystallization effects, and compatibility between the blend matrixes. V C 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40442.

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“…A peak was shown in the 3000 to 2950/cm range using FTIR spectra of carbopol, representing OH stretching vibration. In addition, the carbonyl C═O stretching band was observed within the 1750 to 1700/cm range as a prominent peak of carbopol . However, high peaks for scaffold/Cur, especially in prominent spectra of Cur zone, indicated that Cur exists in the blend sample.…”

Section: Resultsmentioning

confidence: 97%

Wound healing improvement by curcumin‐loaded electrospun nanofibers and BFP‐MSCs as a bioactive dressing

Golchin

Hosseinzadeh

Jouybar

et al. 2020

Polymers for Advanced Techs

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Wound healing, one of the most complex processes of the body involving the cooperation of several important biomolecules and pathways, is one of the major therapeutic and economic issues in regenerative medicine. The present study aimed to introduce a novel electrospun curcumin (Cur)-incorporated chitosan/polyvinyl alcohol/carbopol/polycaprolactone nanofibrous composite for concurrent delivery of the buccal fat pad-derived mesenchymal stem cells (BFP-MSCs) and Cur to a fullthickness wound on the mouse model. Scaffolds were characterized structurally using scanning electron microscopy (SEM), fluorescence microscopy imaging and Fouriertransform infrared spectroscopy, and toxicity of the scaffolds was also evaluated after BFP-MSC seeding by SEM imaging and 3-(4,5 dimethyiazol-2-1)-2-5-diphenyl tetrazolium bromide (MTT) assay. Then, its influence on the wound-healing process was investigated as a wound dressing for a full-thickness skin defect in mouse model.Results demonstrated that the designed composite scaffolds have the capability for cell seeding and support their growth and proliferation. Macroscopic and histopathological characteristics were evaluated at the end of the 7 and 14 days after surgery, and their results showed that our designed scaffold groups accelerated the woundhealing process compared with the control group. Among those, scaffold/Cur, scaffold/Cur/BFP-MSC and scaffold/BFP-MSC groups demonstrated more wound repair efficacy. These results indicated that the combined grafts can be used to improve the wound-healing process, and therefore, the electrospun nanofibers presented in this study, Cur and BFP-MSC together, were demonstrated to have promising potential for wound-dressing applications. K E Y W O R D S chitosan/polyvinyl alcohol/carbopol/polycaprolactone, curcumin, electrospun nanofibers, mesenchymal stem cells, regenerative medicine, wound healing

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Structural Analysis of Ciprofloxacin-Carbopol Polymeric Composites by X-Ray Diffraction and Fourier Transform Infra-Red Spectroscopy

Cited by 26 publications

References 15 publications

Development and Characterization of Sorbitan Monostearate and Sesame Oil-Based Organogels for Topical Delivery of Antimicrobials

Development and Characterization of Sorbitan Monostearate and Sesame Oil-Based Organogels for Topical Delivery of Antimicrobials

Controlled drug delivery studies of biological macromolecules: Sodium alginate and lignosulphonic acid films

Wound healing improvement by curcumin‐loaded electrospun nanofibers and BFP‐MSCs as a bioactive dressing

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