Structural analysis and antiviral activity of a sulfated galactan from the red seaweed Schizymenia binderi (Gigartinales, Rhodophyta)

Inhibition of Japanese Encephalitis Virus Infection by the Sulfated Polysaccharide Extracts from Ulva lactuca

“…The antiviral activities of the sulfated polysaccharides have been shown to be active in the early stage of virus infection, which may be related to interference of virus adsorption and internalization (Duarte et al 2001;Matsuhiro et al 2005;Mazumder et al 2002;Talarico et al 2004). Lee et al (2006) reported that the higher MW of sulfated polysaccharides has better antiviral activities and suggested that viron is prevented from binding to receptor at the early stage.…”

“…Several sulfated polysaccharides, such as heparin, dextran sulfate, pentosan polysulfate, mannan sulfate, and sulfated cyclodextrin, have been shown to inhibit the replication of various enveloped viruses, including herpes simplex virus (HSV), human cytomegalovirus, human immunodeficiency virus (HIV), respiratory synsytial virus, simian immunodeficiency virus, pseudorabies virus, and flaviviruses (Matsuhiro et al 2005;Ono et al 2003;Ponce et al 2003;Pujol et al 2002;Schaeffer and Krylov 2000;Witvrouw and De Clercq 1997). Recently, the antiviral activities of the extracts from Ulva fasciata were shown to be effective against human metapneumovirus (Mendes et al 2010), human T-cell lymphotropic virus type 1 (Romanos et al 2002), and avian influenza viruses (Ivanova et al 1994).…”

Sulfated fucan from marine alga inhibits HeLa cells infection by HTLV-1 free particles: semi-quantitative analysis

“…The antiviral effect of sulfated polysaccharides has been associated with their capability to prevent the interaction between molecules present on the surface of the virus and cellular receptors (Nakashima et al, 1989;Baba et al, 1990;Ida et al, 1994;Witvrouw et al, 1994;Sekine et al, 1995;Hayashi et al, 1996;Romanos et al, 2002b;Matsuhiro et al, 2005;Talarico et al, 2005;Adhikari et al, 2006). In a previous study, we demonstrated that a sulfated fucan from the marine alga Laminaria abyssalis was able to inhibit the interaction between HTLV-1 infected cells and indicator cells, avoiding the syncytium formation, essential for an efficient virus infection (Romanos et al, 2002a).…”

Evaluation of the In Vitro Cytotoxic Activity of Jania rubens Against Jurkat and Molt-4 Human Cancer Cell Lines

“…6 Recent findings showed that seaweeds also contained antiviral, antibacterial, antifungal and antitumour potentials, among numerous others. [7][8][9][10] Here, in our present study we evaluated the in vitro cytotoxic activity of Jania rubens, a red alga which is found in many parts of the world such as Mediterranean, Black Sea, North-Eastern Atlantic (from Norway to Morocco), Indian Ocean and the China Sea, and has been reported to possess many biological activities such as antibacterial, antifungal, anthelminthic, anticancer, analgesic, antipyretic and anti-inflammatory activities. 11,12 We have tested the methanol extract of the red algae for its potential cytotoxic activity against Jurkat and molt-4 cells which are two kinds of human leukemic cell lines.…”