Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis

Tito, Cecília Victoria Agapito; Silvatti, Juliana; Almeida, Izabela; Taniguchi, Elise; Prata, Tiago S.; Paranhos, Augusto; Kayser, Cristiane

doi:10.1007/s10792-021-02124-1

Cited by 1 publication

(3 citation statements)

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“…No significant correlations were found between NFC and OCT parameters. However, patients with osteoarthritis were included in the control group ( 7 ). In another study, the authors observed a thinner RNFL in the lower quadrant (SD-OCT) only in patients with an excavation/vertical disc ratio of 0.5 when compared with the control group ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, the basis of the glaucoma diagnosis was not specified and the NFC classification differed from our study design. The mechanisms underlying the reduction in temporal RNFL thickness in SSc have not been entirely elucidated, but could be associated with greater susceptibility to vasoconstriction, endothelial damage, or ischemia in this region ( 7 ). Due to inconclusive data, further investigations focusing on the relationship between GON and SSc are required to address this issue.…”

Section: Discussionmentioning

confidence: 99%

“…Many ocular manifestations involving the anterior and posterior segments have also been reported in SSc patients (4)(5)(6), and some reports suggest that SSc is a high-risk factor for the development of glaucomatous optic neuropathy (GON), especially normal-tension glaucoma (NTG) (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

Pieklarz,

Gińdzieńska-Sieśkiewicz,

Zawadzka

et al. 2023

Front. Med.

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IntroductionPatients with systemic sclerosis (SSc) present an increased risk of developing glaucomatous optic neuropathy (GON). We investigated peripapillary choroidal parameters and peripapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) to determine the relationships of these factors with clinical variables.MethodsA total of 33 patients with SSc were enrolled and compared to 40 controls. After obtaining circular scans around the optic disc, the global and quadrant peripapillary choroidal thickness (pCT) and RNFL thickness were measured. Additionally, the peripapillary choroidal vascularity index (pCVI), which allows for a quantitative analysis of the choroidal vasculature, was determined.ResultsNo significant differences were found in pCT and RNFL thickness between patients with SSc and controls, or within SSc subtypes (diffuse cutaneous systemic sclerosis (dcSSc) compared to limited cutaneous systemic sclerosis (lcSSc)) (p > 0.05). The pCVI was significantly lower in patients with SSc than in control subjects (64.25 ± 1.94 vs.65.73 ± 2.12, p < 0.001).ConclusionOur results suggest that the statistically significant decrease in pCVI in patients with SSc compared to the control group is probably due to a decrease in the vascular layer, which would partially explain an increased risk of GON in patients with SSc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%