“…Snapshots of key elements in a structural model for hCaSR: subdomain structure of the ECD, hinge region in the VFT, and position of cysteine 482. Model was developed using the StructFast algorithm (Eidogen-Sertanty, Inc., Oceanside, CA) (Debe et al, 2006) on the basis of the structure of mGluR3 (Muto et al, 2007;PDB ID: 2E4U), and displayed with PyMOL (The PyMOL Molecular Graphics System, Version 1.3, Schrödinger, LLC). (A) High level perspective of entire ECD of the hCaSR viewed along the cell surface.…”