Strontium ranelate improves implant osseointegration

Maı̈moun, Laurent; Brennan, Tara Clare; Badoud, Isabelle; Dubois-Ferrière, Victor; Rizzoli, René; Ammann, Patrick

doi:10.1016/j.bone.2010.01.379

Cited by 134 publications

(120 citation statements)

References 34 publications

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“…Mechanical loading on the bone in vivo influences positively the bone mass, promotes the increase of its density and strength, which is confirmed by the data of studying microarchitectures of the lamellar and trabecular bone [4,5,7].…”

supporting

confidence: 56%

“…In particular, such disease as osteoporosis or insufficient dietary intake of protein can negatively affect the quality of the compact bone tissue and impair the process of implant osseointegration as well [3]. And conversely, systemic treatment of osteoporosis can improve osseointegration influencing positively the architectonics and composition of the bone tissue being formed around implants contributing to a greater mechanical strength of the forming bone-implant block [4][5][6].…”

mentioning

confidence: 99%

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Osseointegration of Innovative Customized Implants in the Tubular Bone (Experimental Study)

Горбач¹,

Yemanov²,

Овчинников³

et al. 2017

Sovrem Tehnol Med

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An optimal condition for implant osseointegration is its mechanical stability. However, the process of osseointegration depends on numerous other conditions: mechanical stimulation, implant specific geometry, chemical composition of the surface and its architectonics, topology, and the way of surface relief formation.The aim of the investigation was to assess the capabilities of osseointegration of implants from stainless steel, fabricated by means of additive manufacturing technologies, for rabbit tibia replacement.Materials and Methods. The experiment has been carried out on 6 chinchilla rabbits aged 6-8 months. Amputation of the shin was performed to all animals under general anesthesia, and implants, made with the help of additive manufacturing technologies, were screwed in. The stumps, abutments and implants were fixed during 6 weeks by Ilizarov apparatus. Investigations were performed using clinical, radiographic and histological methods.Results. The findings obtained testify to the ability of the applied screw construction to osseointegration into the tubular bone structure. Neogenesis of bone tissue on the implant surface after 12 weeks provides formation of a bone-implant block ensuring stable implant position in the tubular bone and capability of enduring mechanical load.

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supporting

confidence: 56%

mentioning

confidence: 99%

Osseointegration of Innovative Customized Implants in the Tubular Bone (Experimental Study)

Горбач¹,

Yemanov²,

Овчинников³

et al. 2017

Sovrem Tehnol Med

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show abstract

“…Additional evidence of improved bone strength during strontium ranelate treatment comes from animal and human studies on implant osseointegration and fracture healing (Maimoun et al 2010). Indeed, in rats receiving strontium ranelate for 8 weeks, the resistance to pullout bone implants was increased.…”

Section: Determinants At the Tissue Level: In Vivo Evidencementioning

confidence: 99%

A review on strontium ranelate long-term antifracture efficacy in the treatment of postmenopausal osteoporosis

Cianferotti

D’Asta

Brandi

2013

Therapeutic Advances in Musculoskeletal

100

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Osteoporotic fractures are one of the major causes of increased morbidity and mortality in postmenopausal women and the overall aging population. One of the major issues in the management of postmenopausal osteoporosis is to find a safe and effective treatment in the long term (>3 years) to achieve and maintain a reduction in the risk of fracture. Strontium ranelate (PROTELOS ® ) is a relatively novel drug, currently approved in Europe for the treatment of postmenopausal osteoporosis. Strontium ranelate is the first agent of a new therapeutic class in osteoporosis, capable of both promoting bone formation and, to a lesser extent, inhibiting bone resorption. This uncoupling in bone turnover results in a net gain in bone mineral density (BMD), bone quality improvement and reduction in risk of vertebral and nonvertebral fractures, as initially demonstrated in the preplanned long-term registrative trials SOTI (Spinal Osteoporosis Therapeutic Intervention) and TROPOS (Treatment of Peripheral Osteoporosis) at 5 years. Recently, open-label extensions of the SOTI and TROPOS trials up to 8 and, recently, 10 years have confirmed the sustained efficacy of strontium ranelate in increasing BMD, the long-term safety profile and the high compliance to treatment, independently from baseline BMD or other risk factors for osteoporotic fractures. Recent economic impact analyses have proved that long-term treatment with strontium ranelate is highly cost effective, especially in women older than 70 years of age. Histomorphometric analyses in animals and humans participating in the phase III trials have proved that the quality of mineralization is preserved in the long term and bone microarchitecture is ameliorated, with increased bone strength. Thus, strontium ranelate has been confirmed to be an effective compound for the long-term, chronic treatment of postmenopausal osteoporosis.

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“…It has been reported that applying strontium systematically increases peri-implant bone volume and implant pullout ability in animal subjects with bone-integrated implants. 17,18 It has also been demonstrated that bioactive glass and glass-ceramics that include local strontium show biocompatibility. [19][20][21][22] The positive effects of strontium on peri-implant bone formation have led researchers to develop various methods of local strontium administration.…”

Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study

Durmuş¹,

Turgut²,

Doğan³

et al. 2017

Adv Clin Exp Med

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Strontium ranelate improves implant osseointegration

Cited by 134 publications

References 34 publications

Osseointegration of Innovative Customized Implants in the Tubular Bone (Experimental Study)

Osseointegration of Innovative Customized Implants in the Tubular Bone (Experimental Study)

A review on strontium ranelate long-term antifracture efficacy in the treatment of postmenopausal osteoporosis

Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study

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