Strontium ranelate improves alveolar bone healing in estrogen‐deficient rats

Miranda, Tamires Szeremeske; Napimoga, Marcelo Henrique; Franco, Leonardo; Marins, Letícia Macedo; Malta, Fernando de Souza; Pontes, Louise Antonialice; Morelli, Fernando Mendes; Duarte, Poliana Mendes

doi:10.1002/jper.19-0561

Cited by 15 publications

(5 citation statements)

References 39 publications

(84 reference statements)

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“…The authors recognize that SR prescribed for the treatment of severe osteoporosis was associated with some harmful effects such as increased risk of myocardial infarction and thromboembolic events. However, the scientific interest for the of anabolic effect SR remains intense yy 65,66 . In future studies, it is important to properly evaluate the effects of SR and assess the balance between potential risks and benefits of its use.…”

Section: Resultsmentioning

confidence: 99%

The role of strontium ranelate and guided bone regeneration in osteoporotic and healthy conditions

Mardas

Dereka

Stavropoulos

et al. 2020

J of Periodontal Research

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Background/ objectives SR is a chemical agent developed for the treatment of osteoporosis. In vitro, SR enhanced replication of osteoprogenitor cells and bone formation. In vivo, in ovariectomized rats SR prevented the biomechanical deterioration of bone while in non‐ovariectomized rats, enhanced bone architecture and increased trabecular and cortical bone mass. The aim of this study was to evaluate the effect of SR on bone healing of calvarial critical size defects treated with a deproteinized bovine bone mineral (DBBM) and a collagen barrier (CM), in healthy and osteoporotic rats. Material and methods Sixty‐four, 4‐month‐old Wistar female rats were used. Osteoporosis was induced by ovariectomy and calcium‐deficient diet in half of them. Sixteen ovariectomized (OSR) and 16 healthy (HSR) rats were treated with SR while no medication was administered in the remaining 16 healthy (H) and 16 ovariectomized (O) rats. At 6 weeks after ovariectomy, a 5mm defect was created in each parietal bone of every animal. One defect was treated with DBBM and CM, while the contralateral was left untreated. Qualitative and quantitative histological analysis was performed at 30 and 60 days of healing. A generalized estimating equations test was performed to evaluate the effect of SR and osteoporosis, on new bone formation (NB). Results After 30 days of healing, NB in the untreated defects was 3.4%±1.7%, 4.3%±6.2%, 3.2±4.5%, 15.9±23.5% in O, OSR, H and HSR groups, respectively; after 60 days, NB was 4.7%±4.3%, 11.3%±7%, 7.1%±13.2, 12.1%±13.5%, respectively. In the GBR‐treated defects, after 30 days, NB was 2.6%±1.4%, 2.4%±1.6%, 4.5%±4.1%, 10.3%±14.4% in O, OSR, H and HSR groups, respectively; after 60 days, NB was 2.2%±1.6%, 4.3%±4.2%, 7%±5.1%, 10.8%±17.4%, respectively. Osteoporosis (p=0.008) and the absence of strontium ranelate treatment (p=0.01) had a negative impact on NB. Conclusion SR may promote bone formation in calvarial defects in healthy and osteoporotic rats, albeit in a moderate extent.

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Section: Resultsmentioning

confidence: 99%

The role of strontium ranelate and guided bone regeneration in osteoporotic and healthy conditions

Mardas

Dereka

Stavropoulos

et al. 2020

J of Periodontal Research

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“…In addition, strontium ranelate also intervened the expression of bone markers, seeming to be anti-absorption [ 90 ]. Miranda et al had evaluated the impact of strontium ranelate on the wound healing of tooth-extraction in estrogen-deficient and estrogen-sufficient rats, and found that strontium ranelate benefited bone healing and the expression of bone markers in estrogen-deficient rats, whereas its benefits in estrogen-sufficient rats were modest [ 91 ].…”

Section: Nano-drug Delivery Systemsmentioning

confidence: 99%

Nano-Based Drug Delivery Systems for Periodontal Tissue Regeneration

Chen

Zhang

et al. 2022

Pharmaceutics

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Periodontitis is a dysbiotic biofilm-induced and host-mediated inflammatory disease of tooth supporting tissues that leads to progressive destruction of periodontal ligament and alveolar bone, thereby resulting in gingival recession, deep periodontal pockets, tooth mobility and exfoliation, and aesthetically and functionally compromised dentition. Due to the improved biopharmaceutical and pharmacokinetic properties and targeted and controlled drug release, nano-based drug delivery systems have emerged as a promising strategy for the treatment of periodontal defects, allowing for increased efficacy and safety in controlling local inflammation, establishing a regenerative microenvironment, and regaining bone and attachments. This review provides an overview of nano-based drug delivery systems and illustrates their practical applications, future prospects, and limitations in the field of periodontal tissue regeneration.

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“…Nevertheless, a growing number of studies indicate that they may cause atypical femur fractures, osteonecrosis of the jaw, gastrointestinal and renal complications, and osteochondrosis. Strontium causes a decrease in bone resorption by inhibiting osteoclast formation and differentiation and promoting their apoptosis [16], which may be related to its inhibition of RANKL expression [17]. However, due to the increased risk of heart problems, the use of strontium has been limited to severe osteoporosis, for which other treatments are not available.…”

Section: Introductionmentioning

confidence: 99%

Role and Regulation of Transcription Factors in Osteoclastogenesis

Jiang,

Xia,

Qiao

et al. 2023

IJMS

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Bones serve mechanical and defensive functions, as well as regulating the balance of calcium ions and housing bone marrow.. The qualities of bones do not remain constant. Instead, they fluctuate throughout life, with functions increasing in some situations while deteriorating in others. The synchronization of osteoblast-mediated bone formation and osteoclast-mediated bone resorption is critical for maintaining bone mass and microstructure integrity in a steady state. This equilibrium, however, can be disrupted by a variety of bone pathologies. Excessive osteoclast differentiation can result in osteoporosis, Paget’s disease, osteolytic bone metastases, and rheumatoid arthritis, all of which can adversely affect people’s health. Osteoclast differentiation is regulated by transcription factors NFATc1, MITF, C/EBPα, PU.1, NF-κB, and c-Fos. The transcriptional activity of osteoclasts is largely influenced by developmental and environmental signals with the involvement of co-factors, RNAs, epigenetics, systemic factors, and the microenvironment. In this paper, we review these themes in regard to transcriptional regulation in osteoclastogenesis.

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Strontium ranelate improves alveolar bone healing in estrogen‐deficient rats

Cited by 15 publications

References 39 publications

The role of strontium ranelate and guided bone regeneration in osteoporotic and healthy conditions

The role of strontium ranelate and guided bone regeneration in osteoporotic and healthy conditions

Nano-Based Drug Delivery Systems for Periodontal Tissue Regeneration

Role and Regulation of Transcription Factors in Osteoclastogenesis

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