Strontium‐loaded hydrogel scaffolds to promote gingival fibroblast function

Abstract

Dental implant clinical success is dependent on effective peri‐implant tissue attachment to the trans‐mucosal portion following placement. Modification of transmucosal implant surfaces can improve cellular adhesion and function leading to formation of an effective soft‐tissue seal during healing, of which gingival fibroblasts are prominent cells to migrate to repair wounds and crucial for the development of a collagen rich connective tissue. Biocompatible loaded scaffold materials have been developed to allow local release of molecules with effective biological activity. Our previous studies indicate that strontium can promote gingival fibroblast metabolism, decrease apoptosis and support adhesion to titanium healing abutments. In this study, we developed a strontium‐loaded alginate hydrogel scaffold which can be easily personalized to fit over any size and shape of implant transmucosal collar or healing abutment. Results indicate that biologically active strontium ions are effectively released from loaded alginate hydrogel material to promote fibroblast viability and migration to repair in vitro wounds similar to that of strontium citrate solution. Overall, this novel strontium‐loaded alginate scaffold device displays good biocompatibility and functionality, demonstrating high potential as a system to provide local delivery of strontium to improve peri‐implant mucosal healing following implant placement and clinical success.

Soft and Hard Tissue Integration around Percutaneous Bone-Anchored Titanium Prostheses: Toward Achieving Holistic Biointegration

“…Despite the popularity of bioadhesives for sealing external wounds, only a handful of studies have explored them for wound closure around percutaneous devices, mostly together with stimuli-responsive and targeted drug delivery approaches. For example, the delivery of bioactive strontium from a strontium-alginate hydrogel promoted gingival fibroblast migration into the wound bed necessary for peri-implant soft tissue/mucosal sealing . Apart from drug/therapeutic delivery, bioadhesive composite hydrogels of gelatin methacryloyl (GelMA) and silk fibroin glycidyl methacrylate (SilMA) were used for the delivery of gingival mesenchymal stem cells (GMSCs) for re-epithelization of peri-implant epithelium via anti-inflammatory M2 polarization of macrophages by GMSCs .…”

“…For example, the delivery of bioactive strontium from a strontium-alginate hydrogel promoted gingival fibroblast migration into the wound bed necessary for peri-implant soft tissue/mucosal sealing. 163 Apart from drug/therapeutic delivery, bioadhesive composite hydrogels of gelatin methacryloyl (GelMA) and silk fibroin glycidyl methacrylate (SilMA) were used for the delivery of gingival mesenchymal stem cells (GMSCs) for re-epithelization of peri-implant epithelium via anti-inflammatory M2 polarization of macrophages by GMSCs. 164 Inspired by popular dental restorative adhesives, an antimicrobial peptide, Tet213 laden gelatin methacryloyl (GelMA) dental light curable bioadhesive was formulated for the treatment of peri-implant disease by Shirzaei Sani et al 165 On similar lines, dual hard and soft tissue adhesive nanofiber membranes laden with antimicrobial peptide, D-GL13K was used as a stimuli-responsive/pH-responsive delivery system against oral bacterial infections.…”

Recent Applications and Evaluation of Metal Nanoparticle–Polymer Hybrids as Chronic Wound Dressings

“…SrNPs offer a wide range of uses, including drug delivery, bioimaging, cancer treatment, wound dressings, and more [120]. Personalized SrNPs-loaded scaffolds can be used to accommodate any size dental implant and may aid in patients' healing and tissue attachment [121]. Sr 2+ ions are also one kind of inorganic angiogenic agent that can promote blood vessel development, according to a study [122].…”