Strontium-incorporated mineralized PLLA nanofibrous membranes for promoting bone defect repair

Han, Xiaozhe; Zhou, Xiaojun; Qiu, Kexin; Feng, Wei; Mo, Huimin; Wang, Minqi; Wang, Jinwu; He, Chuanglong

doi:10.1016/j.colsurfb.2019.04.011

Cited by 39 publications

(21 citation statements)

References 53 publications

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“…However, the surface morphology of the hydrogel network changed dramatically after mineralization: the formation of inorganic particles made the smooth surface of the network rough, and the amounts of inorganic particles on the surface of the gel hole increased with the increase of the concentration of calcium and phosphorus mixed solution used in the mineralized gel. 28 The mechanical test results showed that the mechanical strength of PEGDA/HA gel decreased to varying degrees with the change of calcium phosphorus mixture concentration. The reason for this change of PEGDA/ HA gel may due to the different crosslinking degree of crosslinking networks.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

Liu

Jing

et al. 2021

J Biomater Appl

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Scaffolds with osteogenic differentiation function play an important role in the healing process of bone defects. Here, we designed a high strength Poly(ethyleneglycol) diacrylate/Hydroxyapatite (PEGDA/HA) mineralized hydrogel loaded with Exendin4 for inducing osteogenic differentiation. In this study, PEGDA hydrogel was prepared by photo initiating method. PEGDA/HA mineralized hydrogel was prepared by in-situ precipitation method, and Exendin4 was loaded by gel adsorption. The effects of different calcium and phosphorus concentrations on the strength and Exendin4 release of PEGDA/HA hydrogels were investigated. Rat models of bone defect were made and randomly divided into 5 groups. The experimental group was implanted with PEGDA hydrogel, Exendin4-PEGDA hydrogel, PEGDA/HA mineralized hydrogel, Exendin4-PEGDA/HA mineralized hydrogel, and no materials were implanted in the blank control group. Computed tomography (CT) and histology were observed 4 and 8 weeks after operation. Our results revealed that the PEGDA/HA mineralized hydrogel had porous structure, high mechanical strength and good biocompatibility. In vitro release test showed that the mineralized hydrogel exhibited good sustained release profile within 20 d. The animal experiments showed that the mineralized hydrogel accelerated the formation of new bone after 4 and 8 weeks, and formed a seamless union on the defected bone area after 8 weeks. In conclusions, The Exendin4-PEGDA/HA mineralized hydrogel can effectively repair bone defects in rats, and it is expected to be used as a biomaterial for human bone tissue repair.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

Liu

Jing

et al. 2021

J Biomater Appl

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“…First of all, the materials we use, gelatin, PCL, and PLLA are all biocompatible, biodegradable, and approved by the FDA, which have played an important role in bone reconstruction surgery. [26][27][28] Secondly, the solvent we use is 2,2,2-triuoroethanol, which has high volatility and has been volatilized during the production of nano-ber membranes. Finally, sPL is of human origin, and the production process is all pollution-free steps such as centrifugation.…”

Section: Synthesis and Characteristics Of Sustained-release Bioactivementioning

confidence: 99%

Coaxial nanofiber scaffold with super-active platelet lysate to accelerate the repair of bone defects

Huang

Wang

et al. 2020

RSC Adv.

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“…Sr-Containing Nanofibers and the Osteogenic Differentiation of Stem Cells. Stem cells, such as hMSCs, BMSCs, and SHEDs, are considered as a promising cell source for bone engineering due to their unlimited selfrenewal capacity and multiple differentiation potential [68][69][70]. As a principal player in the regenerative process, ECM provides many biological cues for cell adhesion, proliferation, and differentiation.…”

Section: Applications Of Sr-containing Nanofibers In Btermmentioning

confidence: 99%

Electrospun Nanofibers Containing Strontium for Bone Tissue Engineering

Zhang

Zheng

et al. 2020

Journal of Nanomaterials

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Electrospun polymer/metal composite nanofibers have received much attention in the field of bone tissue engineering and regenerative medicine (BTERM) owing to their extracellular matrix- (ECM-) like structure, sufficient mechanical strength, favorable biological properties, and bone induction. In particular, electrospun nanofibers containing strontium (Sr) can significantly promote bone repair and regeneration by mediating osteolysis and osteogenesis, which offers a promising bioactive material for BTERM. In this review, we summarized the effects of electrospun nanofibers containing Sr on stem cells, osteoblasts, and osteoclasts in BTERM. Also, current challenges and future perspectives for electrospun nanofibers containing Sr in BTERM are briefly outlined. It is hoped that the systematic overview will inspire the readers to further study Sr-containing nanofibers for BTERM and accelerate their translation from the bench to the clinic.

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Strontium-incorporated mineralized PLLA nanofibrous membranes for promoting bone defect repair

Cited by 39 publications

References 53 publications

PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

Coaxial nanofiber scaffold with super-active platelet lysate to accelerate the repair of bone defects

Electrospun Nanofibers Containing Strontium for Bone Tissue Engineering

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