Strontium Effects on Human Gingival Fibroblasts

Fernandes, Gabriela; Vanyo, Stephen T.; Alsharif, Shahad B; Andreana, Sebastiano; Visser, Michelle B.; Dziak, Rosemary

doi:10.1563/aaid-joi-d-18-00253

Cited by 11 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This explained why the hydrogels with SrRan showed higher cell viability when compared with hydrogels without SrRan addition. The same effect of a strontium-containing drug on fibroblast growth was observed by Fernandes et al (2019) who concluded that strontium citrate increases the human gingival fibroblast activity. Er et al (2008) also observed that SrRan does have a favorable effect on fibroblast cells at low concentrations.…”

Section: Resultssupporting

confidence: 68%

Calcium Phosphate/Hyaluronic Acid Composite Hydrogels for Local Antiosteoporotic Drug Delivery

Svarca

Grava²,

Dubņika³

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Despite the bone ability of self-regeneration, large bone defects require surgical intervention. Likewise, when it comes to osteoporotic bone fractures, new approaches should be considered a supportive mechanism for the surgery. In recent years, more and more attention has been attracted to advanced drug delivery systems for local osteoporosis treatment, combining appropriate biomaterials with antiosteoporotic drugs, allowing simultaneously to regenerate the bone and locally treat the osteoporosis. Within the current research, hyaluronic acid/strontium ranelate (HA/SrRan), HA/calcium phosphate nanoparticles (HA/CaP NPs), and HA/CaP NPs/SrRan hydrogels were prepared. The effect of CaP and SrRan presence in the composites on the swelling behavior, gel fraction, molecular structure, microstructure, and SrRan and Sr2+ release, as well as in vitro cell viability was evaluated. Obtained results revealed that the route of CaP nanoparticle incorporation into the HA matrix had a significant effect on the hydrogel gel fraction, rheological properties, swelling behavior, and microstructure. Nevertheless, it had a negligible effect on the release kinetics of SrRan and Sr2+. The highest cell (3T3) viability (>80%) was observed for HA hydrogels, with and without SrRan. Moreover, the positive effect of SrRan on 3T3 cells was also demonstrated, showing a significant increase (up to 50%) in cell viability if the used concentrations of SrRan were in the range of 0.05–0.2 μg/ml.

show abstract

Section: Resultssupporting

confidence: 68%

Calcium Phosphate/Hyaluronic Acid Composite Hydrogels for Local Antiosteoporotic Drug Delivery

Svarca

Grava²,

Dubņika³

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…HGF cells in the study were provided by Dr. Visser (Oral Biology Department, University at Buffalo) (IRB number 663292‐1) after being isolated from gingival tissue collected from a healthy patient with no clinical periodontal disease as previously described 18 . Tissue was acquired with approval for research use from the university's Institutional Review Board with written consent obtained.…”

Section: Methodsmentioning

confidence: 99%

Effect of radio frequency glow‐discharge treatment of titanium on human gingival fibroblasts as a function of distance

et al. 2021

Self Cite

View full text Add to dashboard Cite

The mechanical stability and long‐term success of an implant depends on the early healing phase and osseointegration of the bone around it. In addition, a healthy gingival tissue around the implant acts as a barrier that prevents bacteria and pathological byproducts from reaching the implant site. This study investigated the in‐vitro attachment and spreading of human gingival fibroblasts (HGF) on bacterial grade polystyrene (PS) at different distances from radio‐frequency glow‐discharge (RFGD)‐treated commercially pure titanium (cpTi) specimens. Controls included sterile cpTi specimens without RFGD treatment. A second set of experiments utilized media transferred to new bacterial grade polystyrene dishes (no cpTi) after the medium was conditioned by exposure to cpTi, either with or without RFGD treatment, for 24 hr. Surface characterization of the dishes was conducted through contact angle measurements and infrared spectroscopy. Cell numbers and surface areas were determined from Image J analysis of multiple microscopic images of fixed, stained cells. The results showed significantly greater numbers and surface areas on bacterial grade PS dishes at distances up to 15 mm from the RFGD‐treated cpTi groups than for the controls. Moreover, a significant effect of the conditioned medium from RFGD‐treated cpTi versus control cultures was shown on the numbers of fibroblasts attached to bacterial grade polystyrene dishes after 24 hr (p < 0.005) and 48 hr (p = 0.002) incubation. Surface areas of cells exposed to conditioned medium were not significantly different (p ≥ 0.05). Surface characterization of the PS dishes showed a higher value of the critical surface tensions of the treated group when compared to the control group.

show abstract

“…Strontium is considered one of the potential candidates for orthopedic applications in that this element can promote the growth of osteoblast cells [150][151][152]. A certain amount of Sr in Mg alloys can enhance the corrosion resistance [153] and mechanical strength of the alloys [154].…”

Section: LImentioning

confidence: 99%

Biodegradable Magnesium Biomaterials—Road to the Clinic

Amukarimi

Mozafari

2022

Bioengineering

View full text Add to dashboard Cite

In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents, musculoskeletal, and orthopedic applications. With the use of biodegradable Mg biomaterials, patients would not suffer second surgery and surgical pain anymore. Be that as it may, the main drawbacks of these biomaterials are the high corrosion rate and unexpected degradation in physiological environments. Since biodegradable Mg-based implants are expected to show controllable degradation and match the requirements of specific applications, various techniques, such as designing a magnesium alloy and modifying the surface characteristics, are employed to tailor the degradation rate. In this paper, some fundamentals and particular aspects of magnesium degradation in physiological environments are summarized, and approaches to control the degradation behavior of Mg-based biomaterials are presented.

show abstract

Strontium Effects on Human Gingival Fibroblasts

Cited by 11 publications

References 29 publications

Calcium Phosphate/Hyaluronic Acid Composite Hydrogels for Local Antiosteoporotic Drug Delivery

Calcium Phosphate/Hyaluronic Acid Composite Hydrogels for Local Antiosteoporotic Drug Delivery

Effect of radio frequency glow‐discharge treatment of titanium on human gingival fibroblasts as a function of distance

Biodegradable Magnesium Biomaterials—Road to the Clinic

Contact Info

Product

Resources

About