Strontium doped injectable bone cement for potential drug delivery applications

Taha, Ali A.; Akram, Mahreen; Jawad, Zaidoon; Alshemary, Ammar Z.; Hussain, Rafaqat

doi:10.1016/j.msec.2017.05.117

Cited by 35 publications

(27 citation statements)

References 62 publications

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“…We characterized the chemical structure of the particles by 31 P MAS NMR and other complementary techniques. 31 P MAS NMR spectrum of the particles showed the presence of orthophosphate units (Q 0 ) (Figure 3a) [10] that together with the sole detection of P and Ca by EDS (Table 1a) and the absence of calcium phosphate (CP) crystalline structures (Figure 3c) [36][37][38][39], indicates the formation of amorphous CPs. We identified the formation of portlandite (Ca(OH)2) and NH4H2PO4…”

Section: Characterization Of the Nanoparticlesmentioning

confidence: 99%

Feasible and pure P2O5-CaO nanoglasses: An in-depth NMR study of synthesis for the modulation of the bioactive ion release

Martí-Muñoz¹,

Xuriguera

Layton

et al. 2019

Acta Biomaterialia

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The use of bioactive glasses (e.g. silicates, phosphates, borates) has demonstrated to be an effective therapy for the restoration of bone fractures, wound healing and vascularization.Their partial dissolution towards the surrounding tissue has shown to trigger positive bioactive responses, without the necessity of using growth factors or cell therapy, which reduces moneycosts, side effects and increases their translation to the clinics. However, bioactive glasses often need from stabilizers (e.g. SiO4 4-, Ti 4+ , Co 2+ , etc.) that are not highly abundant in the body and which metabolization is not fully understood. In this study, we were focused on synthesizing pure calcium phosphate glasses without the presences of such stabilizers. We combined a mixture of ethyphosphate and calcium 2-methoxyethoxide to synthesize nanoparticles with different compositions and degradability. Synthesis was followed by an in-depth nuclear magnetic resonance characterization, complemented with other techniques that helped us to correlate the chemical structure of the glasses with their physiochemical properties and reaction mechanism.After synthesis, the organically modified xerogel (i.e. calcium monoethylphosphate) was treated at 200 or 350 ºC and its solubility was maintained and controlled due to the elimination of organics, increase of phosphate-calcium interactions and phosphate polycondensation. To the best of our knowledge, we are reporting the first sol-gel synthesis of binary (P2O5-CaO) calcium phosphate glass nanoparticles in terms of continuous poycondensated phosphate chains structure without the

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Section: Characterization Of the Nanoparticlesmentioning

confidence: 99%

Feasible and pure P2O5-CaO nanoglasses: An in-depth NMR study of synthesis for the modulation of the bioactive ion release

Martí-Muñoz¹,

Xuriguera

Layton

et al. 2019

Acta Biomaterialia

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“…Mn 2+ is involved in the regulation of bone remodeling and activates integrins, improving cellular adhesion 5,17,18 . Sr 2+ exhibits beneficial effects on bone formation and resorption processes through osteoblast stimulation and inhibition of osteoclast activity 2,[19][20][21] . However, these effects are often attributed to one specific element without accounting for the contributions of the phase transformations that occur in the studied system.…”

Section: -mentioning

confidence: 99%

Isolating the Effects of Mg2+, Mn2+ and Sr2+ Ions on Osteoblast Behavior from those Caused by Hydroxyapatite Transformation

2020

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Ionic trace elements such as Mg 2+ , Mn 2+ and Sr 2+ are very difficult to stabilize in the hydroxyapatite lattice, and they can induce phase transformations when subjected to thermal treatments. The effects of the ions themselves are often confused with the effects of the newly formed phases. Therefore, the objective of this work was to evaluate the effects of the ions isolated from the effects caused by the inherent phase transformations observed in these systems. WDXRF, XRD, FTIR and biological assays using mouse preosteoblastic cells (MC3T3-E1) showed the Mg 2+ ions can stimulate cell differentiation even when segregated from the HA structure in the form of MgO. However, the presence of MgO considerably retards cell proliferation. At the same time, Mn 2+ ions are able to increase cell proliferation and induce the production of high levels of ALP, regardless of whether they are inserted into the HA structure or segregated in the form of Mn 3 O 4. Finally, the presence of Sr 2+ in the HA lattice does not appear to directly affect cell behavior, since both the proliferation and production of ALP are comparable to those observed in the nondoped HA sample.

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“…Up to now, dozens of Sr-CPCs (Li et al, 2000;Lerous and Lacout, 2001;Cheung et al, 2005;Guo et al, 2005a;Saint-Jean et al, 2005;Wang et al, 2007;Alkhraisat et al, 2008a;Panzavolta et al, 2008;Yu et al, 2009;Pina et al, 2010;Romieu et al, 2010;Kuang et al, 2012;Tadier et al, 2012;Baier et al, 2013;Schumacher et al, 2013;Tao et al, 2013;López et al, 2014;Zhou et al, 2015;D'Onofrio et al, 2016;Singh et al, 2016;Huang et al, 2017;Jayasree et al, 2017;Shi et al, 2017;Taha et al, 2017;Zhu et al, 2017;Lode et al, 2018;No et al, 2019;Wu et al, 2019) with different cement powder compositions or different cement liquid formulations have been developed (see Table 1). As is well known, the Sr 2+ ions could be introduced into the final cement product via cement powder or cement liquid.…”

Section: Introductionmentioning

confidence: 99%

“…− (Lerous and Lacout, 2001), longer setting time (Yu et al, 2009;Singh et al, 2016;Taha et al, 2017), and lower compressive strengths (Saint-Jean et al, 2005;D'Onofrio et al, 2016;Singh et al, 2016). In addition, as a special case, the binary Sr-β-TCP/MCPM system (Alkhraisat et al, 2008b) has been studied and shows a good releasing effect of Sr 2+ ion, but the data about its mechanical properties is not available yet.…”

Section: Introductionmentioning

confidence: 99%

A Novel Fast-Setting Strontium-Containing Hydroxyapatite Bone Cement With a Simple Binary Powder System

Sun

et al. 2021

Front. Bioeng. Biotechnol.

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In recent years, strontium-substituted calcium phosphate bone cement (Sr-CPC) has attracted more and more attentions in the field of bone tissue repair due to its comprehensive advantages of both traditional CPC and Sr ions. In this study, a crucial Sr-containing α-Ca3–xSrx(PO4)2 salt has been synthesized using a simplified one-step method at lower synthesis temperature. A novel Sr-CPC has been developed based on the simple binary Sr-containing α-Ca3–xSrx(PO4)2/Ca4(PO4)2O cement powder. The physicochemical properties and hydration mechanism of this Sr-CPC at various Sr contents were intensively investigated. The setting product of this Sr-CPC after a set for 72 h is a single-phase Sr-containing hydroxyapatite, and its compressive strength slightly decreased and its setting time extended with the increase of Sr content. The hydration process included the initial formation of the medium product CaHPO4⋅2H2O (30 min∼1 h), the following complete hydration of Ca4(PO4)2O and the initially formed CaHPO4⋅2H2O (2∼6 h), and the final self-setting of α-Ca3–xSrx(PO4)2 (6 h∼). The compressive strength of Sr-CPC, which was closely related to the transformation rate of Sr-containing hydroxyapatite, tended to increase with the extension of hydration time. In addition, Sr-CPC possessed favorable cytocompatibility and the effect of Sr ions on cytocompatibility of Sr-CPC was not obvious at low Sr contents. The present study suggests α-Ca3–xSrx(PO4)2 is a kind of vital Sr-containing salt source which is useful to develop some novel Sr-containing biomaterials. In addition, the new Sr-containing cement system based on this simple binary α-Ca3–xSrx(PO4)2/Ca4(PO4)2O cement powder displayed an attractive clinical application potential in orthopedics.

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Strontium doped injectable bone cement for potential drug delivery applications

Cited by 35 publications

References 62 publications

Feasible and pure P2O5-CaO nanoglasses: An in-depth NMR study of synthesis for the modulation of the bioactive ion release

Feasible and pure P2O5-CaO nanoglasses: An in-depth NMR study of synthesis for the modulation of the bioactive ion release

Isolating the Effects of Mg2+, Mn2+ and Sr2+ Ions on Osteoblast Behavior from those Caused by Hydroxyapatite Transformation

A Novel Fast-Setting Strontium-Containing Hydroxyapatite Bone Cement With a Simple Binary Powder System

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