Strontium-doped Hydroxyapatite Coatings Deposited on Mg-4Zn Alloy: Physical-chemical Properties and in vitro Cell Response

Shi, Wei; Dapeng, Zhao; Shang, Peng; Nie, Huan; Yuan, Zhangfu; Tang, Jincheng

doi:10.1016/s1875-5372(18)30194-2

Cited by 11 publications

(6 citation statements)

References 28 publications

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“…Hydroxyapatite in various forms, such as powder, porous blocks, or pearls, can be used to fill bone defects and free spaces in the bone [ 6 , 7 , 8 , 9 ]; these occur when parts of the bone have been removed due to a disease (bone cancer), or when bone extensions are needed (in the case of dental applications). The bone filling will form a skeleton and will facilitate the rapid filling of the pores by the growing natural bone tissue [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite from Natural Sources for Medical Applications

et al. 2022

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The aim of this work is to study the physical-chemical, mechanical, and biocompatible properties of hydroxyapatite obtained by hydrothermal synthesis, at relatively low temperatures and high pressures, starting from natural sources (Rapana whelk shells), knowing that these properties influence the behavior of nanostructured materials in cells or tissues. Thus, hydroxyapatite nanopowders were characterized by chemical analysis, Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), scanning electron microscopy (SEM), and X-ray diffraction (XRD). In vitro studies on osteoblast cell lines (cytotoxicity and cell proliferation), as well as preliminary mechanical tests, have been performed. The results showed that the obtained powders have a crystallite size below 50 nm and particle size less than 100 nm, demonstrating that hydrothermal synthesis led to hydroxyapatite nanocrystalline powders, with a Ca:P ratio close to the stoichiometric ratio and a controlled morphology (spherical particle aggregates). The tensile strength of HAp samples sintered at 1100 °C/90 min varies between 37.6–39.1 N/mm2. HAp samples sintered at 1300 °C/120 min provide better results for the investigated mechanical properties. The coefficient of friction has an appropriate value for biomechanical applications. The results of cell viability showed that the cytotoxic effect is low for all tested samples. Better cell proliferation is observed for osteoblasts grown on square samples.

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Section: Introductionmentioning

confidence: 99%

Hydroxyapatite from Natural Sources for Medical Applications

et al. 2022

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“…It is non-toxic to host cells, which makes it a great alternative for bone tissue transplantation. 31,34,39,41,43,[45][46][47][48][49][50][51][52] The research claims that strontium demonstrates ferroelectric characteristics when doped in HAp, and it relies upon the amount of strontium present in the HAp component. 42 Strontium-doped HAP not only increases its mechanical strength, biocompatibility, and electrical conductivity, but the manufacturing method also impacts the final qualities of the ceramic.…”

Section: Solid-state Synthesis Methodsmentioning

confidence: 99%

“…Strontium-doped HAp increases functionality, including osteoinduction, osteoconduction, mechanical performance, and antibacterial activity. 31–52 Improved corrosion resistance along with increased corrosion potential have been found when HAp has been doped with strontium. 35,36,38,39,41 Most studies have found that strontium doping assists in suppressing bacterial growth and osteoblast formation.…”

Section: Synthesis Routes Explored To Develop Hap In Pure and Doped Formmentioning

confidence: 99%

“…31–52 Improved corrosion resistance along with increased corrosion potential have been found when HAp has been doped with strontium. 35,36,38,39,41 Most studies have found that strontium doping assists in suppressing bacterial growth and osteoblast formation. It is non-toxic to host cells, which makes it a great alternative for bone tissue transplantation.…”

Section: Synthesis Routes Explored To Develop Hap In Pure and Doped Formmentioning

confidence: 99%

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Synthesis of pure and doped nano-calcium phosphates using different conventional methods for biomedical applications: a review

Kawsar,

Sahadat Hossain,

Alam

et al. 2024

J. Mater. Chem. B

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“…Given the values of the CA when SBF media were used, it can be said that the coatings exhibited a superhydrophilic character. Superhydrophilic surfaces (contact angle <10 • ) have been extensively studied, as they improve cell proliferation and attachment and help increase osseointegration capacity [98,99].…”

Section: Contact Angle and Surface Free Energymentioning

confidence: 99%

In Vitro Evaluation of Ag- and Sr-Doped Hydroxyapatite Coatings for Medical Applications

et al. 2023

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Osseointegration plays the most important role in the success of an implant. One of the applications of hydroxyapatite (HAp) is as a coating for metallic implants due to its bioactive nature, which improves osteoconduction. The purpose of this research was to assess the in vitro behavior of HAp undoped and doped with Ag and/or Sr obtained by galvanostatic pulsed electrochemical deposition. The coatings were investigated in terms of chemical bonds, contact angle and surface free energy, electrochemical behavior, in vitro biomineralization in acellular media (SBF and PBS), and biocompatibility with preosteoblasts cells (MC3T3-E1 cell line). The obtained results highlighted the beneficial impact of Ag and/or Sr on the HAp. The FTIR spectra confirmed the presence of hydroxyapatite within all coatings, while in terms of wettability, the contact angle and surface free energy investigations showed that all surfaces were hydrophilic. The in vitro behavior of MC3T3-E1 indicated that the presence of Sr in the HAp coatings as a unique doping agent or in combination with Ag elicited improved cytocompatibility in terms of cell proliferation and osteogenic differentiation. Therefore, the composite HAp-based coatings showed promising potential for bone regeneration applications.

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Strontium-doped Hydroxyapatite Coatings Deposited on Mg-4Zn Alloy: Physical-chemical Properties and in vitro Cell Response

Cited by 11 publications

References 28 publications

Hydroxyapatite from Natural Sources for Medical Applications

Hydroxyapatite from Natural Sources for Medical Applications

Synthesis of pure and doped nano-calcium phosphates using different conventional methods for biomedical applications: a review

In Vitro Evaluation of Ag- and Sr-Doped Hydroxyapatite Coatings for Medical Applications

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