Strontium biokinetic model for mouse-like rodent

Malinovsky, Georgy; Yarmoshenko, Ilia V.; Zhukovsky, Michael; Starichenko, V.I.; Modorov, M. V.

doi:10.1016/j.jenvrad.2012.11.003

Cited by 11 publications

(9 citation statements)

References 29 publications

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“…(2), where y = specific activity of 90 Sr+ 90 Y in the jaw (Bq×g -1 ) and x = β-particle count rate, normalised to the wet weight of the jaw (imp× s -1 × g -1 ) (Malinovsky et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

Stress-associated radiation effects in pygmy wood mouseApodemus uralensis(Muridae, Rodentia) populations from the East-Urals Radioactive Trace

Orekhova

Modorov

2016

Stress

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This work is based on the comparative analysis of data obtained in the course of monitoring pygmy wood mouse populations (Apodemus uralensis Pallas, 1811) in the East-Urals Radioactive Trace (EURT) area and background territories. The effect of population size and its interaction with the radioactivity on biochemical parameters in the spleen and adrenal glands was studied. The concentrations of total lipids, proteins, DNA and RNA, activity of glucose-6-phosphate isomerase and catalase as well as the level of lipid peroxidation (LPO) were evaluated. The functional-metabolic shifts seen with large population sizes were characterized by delipidisation of adrenocortical cells, increased LPO as the main mechanism for steroidogenesis, growth of the protein components of the adrenal glands to maintain their hyperfunction, as well as immunosuppression associated with the restriction of carbohydrates providing splenocytes, reduction of DNA synthesis, and the development of a pro-/antioxidant imbalance. Reactivity of the neuroendocrine and hematopoietic systems of animals experiencing a high population density was higher in the EURT zone compared with the reference group. This difference can be explained by the additional stress from the chronic radiation exposure. The level of LPO, catalase activity, and DNA/protein ratio in the spleen and the total protein content in the adrenal glands were the most sensitive to the interaction of population size and radiation exposure. The harmful effect (distress) of the interaction of non-radiation and radiation factors can manifest when there is a population abundance above 30 ind./100 trap-day and a radiation burden which exceeds the lower boundary of the Derived Consideration Reference Levels, which is above 0.1 mGy/day.

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Section: Methodsmentioning

confidence: 99%

Stress-associated radiation effects in pygmy wood mouseApodemus uralensis(Muridae, Rodentia) populations from the East-Urals Radioactive Trace

Orekhova

Modorov

2016

Stress

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“…These coefficients were calculated using published values of absorbed fractions of beta-radiation energy for different combinations of source and target organs [23] and spectra of 90 Sr and 90 Y radiation [30]. The distribution of 90 Sr in organs and tissues was estimated using existing biokinetic models for mouse-like rodent that was adjusted and verified with published experimental data on strontium retention in the bodies of laboratory and wild mice [31]. External dose was estimated using RESRAD Biota tool [32].…”

Section: Methodsmentioning

confidence: 99%

Assessment of radiation exposure of murine rodents at the EURT territories

et al. 2014

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The study provides data on contemporary levels of radiation exposure of organs and tissues of murine rodents (several species of mice and voles) inhabiting the East-Ural Radioactive Trace. The estimation procedure involves the most advanced approach based on application of appropriate voxel phantom and biokinetic model. Input data for dose assessment are the results of measurements of skeletal 90Sr activity concentration. Maximal internal dose to skeleton, accumulated during 45 days, is 303 mGy. Median internal dose rates on the last day before trapping were 0.83, 0.092 and 0.023 mGy/day for animals trapped at the sites with initial (1957) 90Sr surface contamination >37 MBq/m2, 18.5–37 MBq/m2 and 0.074–18.5 MBq/m2 respectively. Taking to account internal and external exposures, upper boundary of the ICRP Derived Consideration Reference Level (DCRL) is exceeded on the territory with maximal level of the initial 90Sr surface contamination. On the territory with 18.5–37 MBq/m2, whole body mean dose rates to murine rodents exceed the lower boundary of DCRL. On the areas with lower level of surface contamination, even the 90-th percentile of dose rate is below the DCRL.

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“…En effet, les études de biocinétique du 90 Sr montrent clairement un tropisme osseux : plus de 99 % du 90 Sr ingéré s'accumule dans le tissu osseux, où il remplace les atomes de calcium dans les cristaux d'hydroxyapatite. Cette accumulation est cependant dépendante du métabolisme phospho-calcique avec des variations d'accumulation selon l'âge ou le sexe des animaux (Synhaeve et al, 2011 ;Malinovsky et al, 2013) et une accumulation différentielle dans l'os cortical et l'os trabéculaire (Shagina et al, 2003). De plus, les études plus anciennes réalisées dans différents modèles animaux, essentiellement par exposition aiguë, montrent de façon cohérente avec la biolocalisation du 90 Sr une atteinte médullaire et osseuse.…”

Section: Effets Du 137 Cs : éTudes Expérimentalesunclassified

Co-contaminations radiologiques et chimiques en situation post-accidentelle : données récentes et perspectives

2017

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Les accidents nucléaires majeurs ont conduit à la contamination de larges surfaces de terres par un mélange de radionucléides. Les populations humaines vivant actuellement sur ces territoires sont potentiellement contaminées par ingestion de radionucléides sur le long terme. Jusqu'à présent, les études se sont focalisées essentiellement sur le césium-137 ( 137 Cs), en cherchant à établir un lien entre le niveau de contamination des territoires, le niveau de contamination interne des populations et les effets biologiques observés. Cependant, des études expérimentales récentes ont montré des effets du 137 Cs chez le rongeur différents de ceux observés chez les populations contaminées. De plus, l'étude d'autres radionucléides comme le strontium-90 ( 90 Sr) montre l'induction d'effets biologiques qui pourraient en partie expliquer les observations faites chez l'Homme et attribuées à ce jour au 137 Cs. Par ailleurs, les activités industrielles et agricoles conduisent à la dispersion de polluants chimiques dont certains ont des effets toxiques bien décrits. Il en résulte que les études doivent maintenant s'intéresser à des situations d'exposition plus réalistes, avec un mélange de radionucléides et de polluants chimiques. Ceci permettra de compenser le manque de données disponibles sur les effets de mélange, de mieux comprendre les effets sanitaires observés chez les populations vivant dans des zones contaminées et d'améliorer leur protection en situation post-accidentelle.

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Strontium biokinetic model for mouse-like rodent

Cited by 11 publications

References 29 publications

Stress-associated radiation effects in pygmy wood mouseApodemus uralensis(Muridae, Rodentia) populations from the East-Urals Radioactive Trace

Stress-associated radiation effects in pygmy wood mouseApodemus uralensis(Muridae, Rodentia) populations from the East-Urals Radioactive Trace

Assessment of radiation exposure of murine rodents at the EURT territories

Co-contaminations radiologiques et chimiques en situation post-accidentelle : données récentes et perspectives

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