Strontium and Bone

Cabrera, Walter; Schrooten, Iris; Broe, Marc E. De; D’Haese, Patrick C.

doi:10.1359/jbmr.1999.14.5.661

Cited by 160 publications

(112 citation statements)

References 69 publications

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“…Strontium is known to follow a similar physiological pathway in humans as calcium, where a large portion accumulates in bone via ionic exchange of calcium for strontium, thus it has been used in bone therapies [24]. However, controversy does exist in the use of strontium in bone health products due to its ability to displace calcium in the bone at high concentrations and reside there, which in turn leads to increased attenuation of x-rays, leading to overestimation of bone mineral density (BMD) values [25,26]. By incorporating strontium into a fully degradable material, it should be possible to achieve a controlled release of strontium into the body over time.…”

Section: Introductionmentioning

confidence: 99%

Structural and physico-chemical analysis of calcium/strontium substituted, near-invert phosphate based glasses for biomedical applications

Patel¹,

Moss²,

Hossain³

et al. 2017

Acta Biomaterialia

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Neutron diffraction, 23 Na and 31 P NMR and FTIR spectroscopy have been used to investigate the structural effects of substituting CaO with SrO in a 40P 2 O 5 ·(16-x)CaO·20Na 2 O·24MgO·xSrO glass, where x is 0, 4, 8, 12 and 16 mol%. The 31 P solid-state NMR results showed similar amounts of Q 1 and Q 2 units for all of the multicomponent glasses investigated, showing that the substitution of Sr for Ca has no effect on the phosphate network. The M-O coordinations (M= Mg, Ca, Sr, Na) were determined for binary alkali and alkaline earth metaphosphates using neutron diffraction and broad asymmetric distributions of bond length were observed, with coordination numbers that were smaller and bond lengths that were shorter than in corresponding crystals. The Mg-O coordination number was determined most reliably as 5.0(2). The neutron diffraction results for the multicomponent glasses are consistent with a structural model in which the coordination of Ca, Sr and Na is the same as in the binary metaphosphate glass, whereas there is a definite shift of Mg-O bonds to longer distance. There is also a small but consistent increase in the Mg-O coordination number and the width of the distribution of Mg-O bond lengths, as Sr substitutes for Ca. Functional properties, including glass transition temperatures, thermal processing windows, dissolution rates and ion release profiles were also investigated. Dissolution studies showed a decrease in dissolution rate with initial addition of 4 mol% SrO, but further addition of SrO showed little change. The ion release profiles followed a similar trend to the dissolution rates observed. The limited changes in structure and dissolution rates observed for substitution of Ca with Sr in these fixed 40 mol% P 2 O 5 glasses were attributed to their similarities in terms of ionic size and charge.

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Section: Introductionmentioning

confidence: 99%

Structural and physico-chemical analysis of calcium/strontium substituted, near-invert phosphate based glasses for biomedical applications

Patel¹,

Moss²,

Hossain³

et al. 2017

Acta Biomaterialia

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“…Thus, strontium may be of potential benefit for the treatment of osteoporosis [12] . Following the formulation of strontium ranelate (Protelos; Servier Laboratories, France), strontium treatment has been considered to be an important advance in the pharmacotherapy of osteoporosis because strontium has demonstrated both anti-resorptive and bone-forming effects [13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway

Zhang

et al. 2012

Acta Pharmacol Sin

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Aim: To evaluate the protective effects of strontium fructose 1,6-diphosphate (FDP-Sr), a novel strontium salt that combined fructose 1,6-diphosphate (FDP) with strontium, on bone in an ovariectomy-induced model of bone loss. Methods: Eighty female Sprague-Dawley rats were ovariectomized (OVX) or sham-operated. Three months later, the rats were assigned to six groups (10 for each): sham-operated, OVX control, OVX+FDP-Sr (110, 220, or 440 mg/kg), or OVX+strontium ranelate (SR, 180 mg/kg). Drugs were administered orally for 3 months. When the treatment was terminated, the following parameters were assessed: bone mineral density (BMD), the biomechanical properties of the femur and lumbar vertebrae, trabecular histomorphology, serum phosphorus, calcium, bone-specific alkaline phosphatase (B-ALP), tartrate-resistant acid phosphatase 5b (TRACP5b), N-telopeptide of type I collagen (NTx) and a series of markers for oxidative stress. Receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) levels in serum were measured using ELISA and their gene expression levels in the bone were measured using R-T PCR. Results: Treatment with FDP-Sr (220 or 440 mg/kg) or SR (180 mg/kg) significantly increased the BMD and improved the bone microarchitecture and bone strength in OVX rats. The treatments also decreased in the levels of H 2 O 2 and MDA, restored the CAT level in serum and bone marrow, increased the serum B-ALP and decreased NTx and TRACP 5b in OVX rats. Treatment with FDP-Sr decreased the RANKL level, and increased the OPG level in serum in a dose-dependent manner. It also significantly down-regulated the RANKL expression and up-regulated OPG expression in bone marrow. Conclusion: FDP-Sr may be an effectve treatment for postmenopausal osteoporosis that acts, in part, via a decrease in osteoclastogenesis through the OPG\RANKL\RANK pathway.Keywords: osteoporosis; ovariectomy; strontium fructose 1,6-diphosphate; strontium ranelate; osteoprotegerin (OPG); receptor activator of NF-κB ligand (RANKL); bone mineral density; tartrate-resistant acid phosphatase 5 (TRACP5); N-telopeptide of type I collagen (NTx)

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“…In marine water, strontium is the most abundant trace element, reaching values of 8 mg/L. (Cabrera et al, 1999) In its natural state, called stable strontium, this element is not radioactive and it is harmless. The only compound harmful for the human being is strontium chromate, and due to chrome not to strontium.…”

Section: Adverse Effectsmentioning

confidence: 99%

“…(Giammarile et al, 1999;Saarto et al, 2002) Afterwards this isotope, together with strontium-88, have been used as markers for calcium absorption. (Cabrera et al, 1999) …”

Section: Adverse Effectsmentioning

confidence: 99%