Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing

Ray, Seemun; Thormann, Ulrich; Eichelroth, Marlen; Budak, Matthäus; Biehl, Christoph; Rupp, Markus; Sommer, Ursula; Khassawna, Thaqif El; Alagboso, Francisca I.; Kampschulte, Marian; Rohnke, Marcus; Henß, Anja; Peppler, Klaus; Linke, Vanessa; Quadbeck, Peter; Voigt, Axel; Stenger, Florian; Karl, Daniel; Schnettler, Reinhard; Heiß, Christian; Lips, Katrin Susanne; Alt, Volker

doi:10.1016/j.biomaterials.2017.11.049

Cited by 76 publications

(55 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high surface area would accelerate the in vivo degradation when an appropriate porosity was applied. In addition to the porous structure design, the surface modification is preferred with superior controllability to modulate the degradation rate [ 155 , 156 ]. Moreover, the CaP coating could possibly change the degradation mechanism to reduce the harmful iron phosphate-based components [ 155 , 156 ].…”

Section: Surface Biofunctions With Calcium Phosphate Coatingsmentioning

confidence: 99%

Biofunctionalization of metallic implants by calcium phosphate coatings

Cockerill

Zheng

et al. 2019

Bioactive Materials

182

105

View full text Add to dashboard Cite

Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability. Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions. Calcium phosphates (CaPs) are the major inorganic component of bone tissues, and thus owning inherent biocompatibility and osseointegration properties. As such, they have been widely used in clinical orthopedics and dentistry. The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs. This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings. We first glance over different types of CaPs with their coating methods and in vitro and in vivo performances, and then give insight into the representative biofunctions, i.e. osteointegration, corrosion resistance and biodegradation control, and antibacterial property, provided by CaP coatings for metallic implant materials.

show abstract

Section: Surface Biofunctions With Calcium Phosphate Coatingsmentioning

confidence: 99%

Biofunctionalization of metallic implants by calcium phosphate coatings

Cockerill

Zheng

et al. 2019

Bioactive Materials

182

105

View full text Add to dashboard Cite

show abstract

“…Due to the good porosity at low costs, scaffolds are often used in cases of disturbed bone healing and in setting of tumorous bone disease [40]. Furthermore, the use of mineral agents like calcium phosphate cement added with active ingredients such as strontium or nanoparticles loaded on scaffolds such as nanosilicates (poly (glycerol sebacate)) showed an improved mineralization in vivo and in vitro [4,42]. Beside the long way until becoming a certified product, all the above-mentioned technologies are still in the early stages of development with many unknown factors.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Implant Survival and Success Rates

Attia

Narberhaus

Schaaf

et al. 2020

JCM

View full text Add to dashboard Cite

The atrophic maxilla often requires bone augmentation before implant placement to ensure long-term implant success. A previous prospective clinical trial examined the use of platelet-rich plasma (PRP) during maxillary augmentation. The short-term results showed no positive effect of PRP. The aim of this study was to evaluate the same patient collective of the previous study regarding the PRP long-term impact on the survival and success of dental implants. Fifty-three patients from the previous study diagnosed with maxillary atrophy and augmented with autologous bone grafts from the iliac crest and dental implants, were included in this study. Treatment was carried out on both sides in 34 patients with a split-mouth-design in which one randomly chosen side was treated additionally with PRP, the other side was the control-side. Nineteen patients were treated only on one side and were assigned to the PRP—or the control group randomly. Implant follow-up of the patients from the previous study was performed after an average time of 13 years. Implant success was evaluated using two different success criteria. Thitry-seven patients (25 women and 12 men) were investigated in this study. Seventeen patients (12 female, 5 male) were included in the PRP group, while 20 patients (13 female, 7 male) participated in the control group. A total of 210 implants were inserted. Of these, 102 implants (48.57%) were placed in the PRP group and 108 implants (51.42%) in the control group. Out of 102 investigated implants in the PRP group, 6 were removed (survival rate 94.1%). While two of the 108 implants in the control group were loss (survival rate 98.1%). In the PRP group, the cumulative probability of survival after 15.1 years was 94.1% and in the control group, was 98.1%, with no significant difference between the two groups. Higher significant difference for the control group was found in the cumulative success probability using Albrektson criteria (p = 0.05). Positive impact of PRP on long-term implant survival and success could not be found.

show abstract

“…Different compounds could enhance osteoblasts or inhibit osteoclasts in vitro such as Donepezil [45]. The use of minerals such as calcium phosphate cements doped with active ingredients such as strontium [46] or nanoparticles loaded on scaffolds such as nanosilicates poly(glycerol sebacate) [13], showed enhanced mineralization in vivo and in vitro.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Retrospective Clinical and Radiological Outcomes of a Randomized Controlled Clinical Trial

Attia

Narberhaus

Schaaf

et al. 2020

JCM

View full text Add to dashboard Cite

The long-term clinical and radiological outcomes of dental implants inserted in augmented bone treated with platelet-rich plasma (PRP) has not been well addressed in the literature yet. This study is based on a collection of patients from a randomized controlled trial (RCT) that did not report any short-term positive effects of PRP on bone healing after sinus lift surgery using autologous iliac crest bone graft. This study aimed to evaluate the long-term impact of PRP regarding clinical and radiological outcomes on the inserted implants in the previous RCT. For this evaluation, we considered the following variables: plaque index, probing depth, bleeding index, mobility grade, Periotest® values, and radiological bone loss. Out of 53 patients (n = 306 implants) included in the previous study we were able to reinvestigate 37 patients (n = 210 implants) in two centers (31 in Giessen, Germany and 6 in Erlangen, Germany). Clinical and radiographic parameters suggested overall healthy conditions of the peri-implant tissue. The PRP-group and the control group did not differ significantly in the majority of the parameters. The overall evaluation showed that result data of the PRP-group was inferior to the control group in 64 percent of the evaluated parameters. The present study cannot provide evidence of a positive effect of PRP on the long-term implant clinical and radiological outcomes. In fact, a tendency towards inferior long-term results in the PRP-group was detected without reaching a significant threshold. Further controlled trials need to be conducted to investigate this correlation.

show abstract

Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing

Cited by 76 publications

References 68 publications

Biofunctionalization of metallic implants by calcium phosphate coatings

Biofunctionalization of metallic implants by calcium phosphate coatings

Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Implant Survival and Success Rates

Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Retrospective Clinical and Radiological Outcomes of a Randomized Controlled Clinical Trial

Contact Info

Product

Resources

About