Strontium-87m lung scans in pulmonary aspergillosis

Pk, Rohatgi; Simon, DB; Goldstein, RA; Rc, Reba

doi:10.2214/ajr.129.5.879

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…The use of radioactive strontium lung scans has been proposed because A spergillus furnigatus produces a metabolite at loci of infection that binds strontium. Unfortunately, clinical evaluations have not found this approach to be reliable (143). Investigators at the Baltimore Cancer Center have suggested that positive surveillance cultures may be predictive of subsequent aspergillosis (144).…”

Section: Invasive Pulmonary Infection Invasive Aspergillusmentioning

confidence: 99%

Aspergillosis

Bodey

Vartivarian

1989

Eur. J. Clin. Microbiol. Infect. Dis.

302

228

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Aspergillus spores are ubiquitous in the environment and may become concentrated in hospital ventilation systems. Colonization in normal hosts can lead to allergic diseases ranging from asthma to allergic bronchopulmonary aspergillosis. Normal hosts rarely develop invasive disease, which is primarily an infection of severely immunocompromised patients. The major predisposing factors for infection include prolonged neutropenia, chronic administration of adrenal corticosteroids, the insertion of prosthetic devices, and tissue damage due to prior infection or trauma. Since Aspergillus spp. are respiratory pathogens, the most common form of infection is pneumonia followed by sinusitis. Patients with preexistant cavitary disease may develop noninvasive aspergillomas. Most infections are caused by Aspergillus fumigatus. The organism is capable of invading across all natural barriers, including cartilage and bone. It has a propensity for invading blood vessels causing thrombosis and infarction. The diagnosis of pulmonary infection is usually difficult to establish because the organism is seldom cultured from sputum and can represent contamination in some cases. Therapy is immunocompromised hosts is less than satisfactory and amphotericin B is the only agent with significant activity. There is anecdotal evidence to suggest that the addition of 5-fluorocytosine to amphotericin B may be beneficial.

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Section: Invasive Pulmonary Infection Invasive Aspergillusmentioning

confidence: 99%