Strongyloidiasis presenting as duodenal obstruction in a patient infected with human T-cell lymphotropic virus type 1

Hindy, Pierre; Parvin, Russell; Hanna, Kayane; Gress, Frank G.

doi:10.1016/j.gie.2010.11.035

Cited by 12 publications

(12 citation statements)

References 8 publications

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“…Unusual manifestations of chronic strongyloidiasis include reactive arthritis [9], nephrotic syndrome [10], chronic malabsorption [11], duodenal obstruction [12], focal hepatic lesions [13], and recurrent asthma [14]. …”

Section: Chronic Strongyloidiasismentioning

confidence: 99%

Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis

Mejia

Nutman

2012

Current Opinion in Infectious Diseases

311

303

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Section: Chronic Strongyloidiasismentioning

confidence: 99%

Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis

Mejia

Nutman

2012

Current Opinion in Infectious Diseases

311

303

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“…On the other hand, the negative regulation of IL-4 in individuals coinfected with S. stercoralis and HTLV-1 can cause deficient IgE responses which are important in controlling this parasite. Hence, infection by the HTLV-1 virus is an important risk factor for developing severe disseminated strongyloidiasis, given that these are comorbidities which influence the host's immune response [10,[27][28][29][30]. If on the one hand it is clear that HTLV-1 favors the appearance of severe forms of strongyloidiasis, studies are necessary to determine how it is that S. stercoralis changes the course of infection by HTLV-1 [31].…”

Section: Resultsmentioning

confidence: 99%

The Influence of Human T-Lymphotropic Virus 1 on Patients Coinfected by the Helminth Strongyloides stercoralis

Rodrigues¹,

Felipe²,

Arruda³

et al. 2019

Int J Trop Dis

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Strongyloides stercoralis is the helminth which causes strongyloidiasis, a neglected disease, with a global prevalence estimated at 60 million people infected, principally in tropical regions. The parasite's proliferation occurs mainly in immunosuppressed hosts, in particular, patients carrying Human T-lymphotropic virus 1 (HTLV-1), which is responsible for the infection of cells of the immune system. As a result, we aimed to identify and discuss clinical and pathological aspects of infection by S. stercoralis in patients carrying HTLV-1. This is an exploratory study, of the literature review type. The search was undertaken in the PubMed, Scielo, Web of Science, Science Direct and Biblioteca Virtual emSaúde (BVS) databases in August 2016. The criteria for the inclusion of articles were: Language, published in the last 20 years, and to be relevant to the guiding question. After reading of the titles, 60 articles were excluded, and after reading of the abstracts, a further 70. Of the 56 articles remaining, 16 were excluded after reading the article in full. After analysis of the material, only 40 studies met the criteria established. The studies showed that this type of coinfection is found in the same specific population groups which are vulnerable to the diseases, as well as immunomodulation of the Th2 pattern, promoted by the presence of S. stercoralis and the difficulties related to the diagnosis of Strongyloidiasis. It is concluded that it is necessary to screen for HTLV-1in cases of infection by S. stercoralis, so as to initiate fast and efficient treatment against this coinfection.

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“…Strongyloides enteritis is a rare cause of duodenal obstruction, but potentially fatal if unrecognised. Few cases have been reported in the literature; one case series reported only nine cases between 1979 and 2010 5 6. Only one of these had coexisting HTLV-1 infection.…”

Section: Discussionmentioning

confidence: 99%

Strongyloides, HTLV-1 and small bowel obstruction

et al. 2019

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An 81-year-old Jamaican man who has been resident in the UK for many years presented with one week history of generalised abdominal pain, postprandial vomiting, anorexia, weight loss and abdominal distension. He was managed conservatively for acute small bowel obstruction. Investigations revealed a duodenal stricture. Live Strongyloides stercoralis larvae were observed in stool samples and duodenal biopsy confirmed the presence of the parasite at multiple life cycle stages within the lamina propria. He was diagnosed with Strongyloides hyperinfection with underlying human T-cell lymphotropic virus type 1 and treated with a prolonged course of ivermectin with ongoing monitoring for relapse. This case demonstrates a rare but potentially fatal cause of small bowel obstruction.

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Strongyloidiasis presenting as duodenal obstruction in a patient infected with human T-cell lymphotropic virus type 1

Cited by 12 publications

References 8 publications

Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis

Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis

The Influence of Human T-Lymphotropic Virus 1 on Patients Coinfected by the Helminth Strongyloides stercoralis

Strongyloides, HTLV-1 and small bowel obstruction

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