Strongyloides stercoralis hyperinfection in an immunosuppressed dog from France

Cervone, Mario; Giannelli, Alessio; Otranto, Domenico; Perrucci, Stefania

doi:10.1016/j.anicom.2016.05.001

Cited by 22 publications

(40 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most publications indicate that the symptoms of strongyloidiasis in dogs include dermatological manifestations, signs of lung damage (shortness of breath, cough, wheezing, mucus secretion) and gastrointestinal lesions [1,6]. In dogs with immunosuppression in addition to the symptoms described above, there may be hematocesis, hematomesis [9]. The chronic course of the invasion is accompanied by weight loss, loss of appetite, stunted growth and development of puppies and young dogs.…”

Section: Introductionmentioning

confidence: 99%

Distribution of Strongyloides Stercoralis Among Dogs of Different Housing Groups in Kyiv and Kyiv Region, Clinical Manifestations and Diagnostic Methods

Dashchenko

Soroka

Semenko

2020

EUREKA: Health Sciences

View full text Add to dashboard Cite

Strongyloidiasis in dogs, despite its uncertain zoonotic status, is potentially danger for dogs owners. It is considered that strongyloidiases characteristic for tropical and subtropical regions, but in recent years it is increasingly found in non-endemic countries. The aim. To determine the extent of the invasion, clinical signs and diagnostic methods of strongyloidiasis in dogs of different groups in Kyiv and Kyiv region. Materials and methods. A total of 364 dogs were studied (130 animals lived in shelters (Group 1) and 234 in homes (Group 2). Diagnosis of strongyloidiasis was performed by native smear and Baerman methods. Additionally, the sensitivity of the modified string test was tested. Samples of venous blood were taken from dogs with confirmed strongyloidiasis for haematological and biochemical analysis. Results. A study found that the extent of invasion (EI) in shelters and home dogs was 3.0±0.36 % (4/130; Group 1) and 2.5±0.25 % % (6/234; Group 2) respectively. It was found that three repetitions of the Baerman method test increased its efficiency to 90.5 %. The sensitivity of the modified string test was 100 %. Clinical manifestations included disorders of the respiratory (20 %: 2/10) and digestive systems (80 %: 8/10), weight loss (70 %: 7/10). Blood tests did not reveal changes specific to strongyloidiasis, eosinophilia was observed in only one dog in the acute stage of the disease. Conclusions. The results of our studies indicate the presence of strongyloidiasis in dogs in Kyiv and Kyiv region and probability of the spread of the pathogen in the environment. Symptoms in dogs with strongyloidiasis were nonspecific and cannot be used for diagnosis. A modified string test and Baerman method has demonstrated high efficacy and may be recommended to clarify the diagnosis of a chronic invasion.

show abstract

Section: Introductionmentioning

confidence: 99%

Distribution of Strongyloides Stercoralis Among Dogs of Different Housing Groups in Kyiv and Kyiv Region, Clinical Manifestations and Diagnostic Methods

Dashchenko

Soroka

Semenko

2020

EUREKA: Health Sciences

View full text Add to dashboard Cite

show abstract

“…However, in immunocompromised patients, strongyloidiasis can cause severe generalized and complicated fatal systemic infections from exponential multiplication and dissemination of autoinfective S. stercoralis third-stage larvae (aL3) which involve gastrointestinal, respiratory, central nervous systems [20,21]. Hyperinfection syndrome occurs when aL3 penetrate the small intestinal mucosa in large numbers and migrate somatically, resulting in severe systemic symptoms and organ failure [22]. Hyperinfection syndrome is commonly reported in individuals under corticosteroid treatment and cases of human Tlymphotropic virus type 1 (HTLV-1) co-infection with S. stercoralis [21,23].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Molecular and Cellular Biology of Strongyloides spp.

Jaleta

Lok

2019

Curr Trop Med Rep

View full text Add to dashboard Cite

Purpose of Review This paper constitutes an update of recent studies on the general biology, molecular genetics, and cellular biology of Strongyloides spp. and related parasitic nematodes. Recent Findings Increasingly, human strongyloidiasis is considered the most neglected of neglected tropical diseases. Despite this, the last 5 years has seen remarkable advances in the molecular biology of Strongyloides spp. Genome sequences for S. stercoralis, S. ratti, S. venezuelensis, S. papillosus, and the related parasite Parastrongyloides trichosuri were created, annotated, and analyzed. These genomic resources, along with a practical transgenesis platform for Strongyloides spp., aided a major achievement, the advent of targeted mutagenesis via CRISPR/Cas9 in S. stercoralis and S. ratti. The genome sequences have also enabled significant molecular epidemiologic and phylogenetic findings on human strongyloidiasis, including the first genetic evidence of zoonotic transmission of S. stercoralis between dogs and humans. Studies of molecular signaling pathways identified the nuclear receptor Ss-DAF-12 as one that can be manipulated in the parasite by exogenous application of its steroid ligands. The chemotherapeutic implications of this were unscored by a study in which a Ss-DAF-12 ligand suppressed autoinfection by S. stercoralis in a new murine model of human strongyloidiasis. Summary Seminal advances in genomics of Strongyloides spp. have transformed research into strongyloidiasis, facilitating fundamental phylogenetic and epidemiologic studies and aiding the deployment of CRISPR/Cas9 gene disruption and editing as functional genomic tools in Strongyloides spp. Studies of Ss-DAF-12 signaling in S. stercoralis demonstrated the potential of this pathway as a novel chemotherapeutic target in parasitic nematodes.

show abstract

“…The hatched firststage larvae (L1) contaminate the environment through the faeces. In the environment, L1 moult to infective third-stage larvae (L3) that can infect a host primarily by penetration of the skin and rarely by ingestion (4). The transmammary route of infection is also described, but it is controversial and can occur if the bitch gets infected in late gestation and during lactation (5,6).…”

Section: Introductionmentioning

confidence: 99%

“…Autoinfection can occur if the L1 develop to infective L3 before leaving the host's digestive tract, and is often associated with immunosuppression. Immunocompromised dogs may also develop a severe hyperinfection (L3 that migrate throughout the body) that is related to the acute form of the disease (1,4). The prepatent period is 5-21 days (1).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

First Case of Strongyloides stercoralis Infection in a Dog in the Republic of Macedonia

Cvetkovikj

Rashikj

Celeska

et al. 2018

Macedonian Veterinary Review

View full text Add to dashboard Cite

A six-month-old Pomeranian male dog was referred due to a month long history of unformed, soft faeces and mild weight loss. Stool analyses by direct faecal smear, Zinc sulphate flotation and the Baermann concentration method revealed an infection with Strongyloides stercoralis. The dog was initially treated once with a combination drug of praziquantel, pyrantel and febantel (½ Drontal® Plus Tablets for puppies and small dogs; Bayer; i.e. 31.5 mg/kg bodyweight of febantel ). The treatment was repeated after 12 days with the same dosage for 3 consecutive days. The stool analyses performed 14 days and 3 months after the second treatment were negative for S. stercoralis larvae. The results suggest that a repeated treatment with Drontal® Plus Tablets is effective against S. stercoralis in dogs and has no adverse effects.

show abstract

Strongyloides stercoralis hyperinfection in an immunosuppressed dog from France

Cited by 22 publications

References 22 publications

Distribution of Strongyloides Stercoralis Among Dogs of Different Housing Groups in Kyiv and Kyiv Region, Clinical Manifestations and Diagnostic Methods

Distribution of Strongyloides Stercoralis Among Dogs of Different Housing Groups in Kyiv and Kyiv Region, Clinical Manifestations and Diagnostic Methods

Advances in the Molecular and Cellular Biology of Strongyloides spp.

First Case of Strongyloides stercoralis Infection in a Dog in the Republic of Macedonia

Contact Info

Product

Resources

About