Stronger susceptibilities to air pollutants of influenza A than B were identified in subtropical Shenzhen, China

Ma, Pan; Zhou, Ning; Wang, Xinzi; Zhang, Ying; Tang, Xiaoxin; Yang, Yang; Ma, Xiaoqian; Wang, Shigong

doi:10.1016/j.envres.2022.115100

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…6 Our study is subject to several limitations. First, the dynamics of in uenza pandemics are in uenced by a variety of factors, including air pollution (47)(48)(49)(50)(51)(52)(53) and humidity (43,(54)(55)(56), and public health infrastructure (57), which could explain at least part of the estimated increase in risk. Second, our in uenza incidence data are mainly derived from case reports collected through the FluNet of national surveillance.…”

Section: Discussionmentioning

confidence: 99%

The association between Ambient Temperature and Influenza Activity across 124 countries globally during 2014–2019

Cao,

Luo,

Zhu

et al. 2024

Preprint

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Background: The results of the association between ambient temperature and influenza in previous studies have been inconsistent in different regions. And global, multi-regional studies are lacking. Methods: Our study used two stages of analysis to further evaluate the association between ambient temperature and influenza activity at regional and global scales. Meteorological data and influenza data were collected in 124 countries during 2014–2019. The country-specific associations between weekly mean temperature and the risk of all types of influenza (Flu-All)), influenza A (Flu-A), and influenza B (Flu-B) were estimated by using a distributed lag non-linear model (DLNM), and the pooled regional and global effects by using multilevel meta-analysis. Climate zones and influenza transmission zones performed stratified analyses. Results: There was a non-linear curve relating ambient temperature to influenza risk in 124 countries. Within the optimal lag of 2 weeks, a bimodal (M-shaped) relationship was observed between temperature and influenza risk, with two risk peaks at -8°C with two RR of 6.02 (95% CI: 1.92-20.77) and of 3.76 (95% CI: 2.39-5.91), and at 22°C with two RR of 3.08 (95% CI: 1.27-7.49) and 2.08 (95% CI: 1.55-2.80). For Flu-B, it was N-shaped, peaking at 1°C with an RR of 4.48 (95%CI: 1.74-11.55). Risk curves fitted under geographic location-induced influenza transmission pattern zones showed a more characteristic shape than risk curves fitted under climatic zones. Conclusions: Globally, low temperatures significantly increased the risk of influenza, and Flu-A activity dominated throughout the year with two peaks. Geographic homogeneity was relatively dominant concerning the cumulative association of influenza activity with temperature. The findings have important implications for the development of strategies to control global and regional influenza and respond to climate change.

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Section: Discussionmentioning

confidence: 99%

The association between Ambient Temperature and Influenza Activity across 124 countries globally during 2014–2019

Cao,

Luo,

Zhu

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…8,9,38 Serving as virus carriers, large particles (with diameters greater than several micrometers) tend to mainly deposit in the upper airway while smaller particles can travel further and penetrate deeper into the lung alveolar region before resulting in subsequent infection. 10,11 Previous investigations have associated exposure to PM with susceptibility of different types of respiratory viruses, including human influenza virus, 12,13 Middle East respiratory syndrome coronavirus (MERS-CoV), 14 and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 15 In part, it has been proposed that PM exposure was related to the risk ratio and clinical severity of patients with respiratory viral infection (i.e., SARS-CoV-2) due to the oxidative stress and the inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological evidence has associated exposure to air pollutants, especially fine particulate matter (PM 2.5 ), with the severity and mortality of respiratory viral infections. − Amid the rapid airborne transmission of respiratory viruses, − viral RNA has been frequently detected in indoor and outdoor PM. ,, Serving as virus carriers, large particles (with diameters greater than several micrometers) tend to mainly deposit in the upper airway while smaller particles can travel further and penetrate deeper into the lung alveolar region before resulting in subsequent infection. , Previous investigations have associated exposure to PM with susceptibility of different types of respiratory viruses, including human influenza virus, , Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) . In part, it has been proposed that PM exposure was related to the risk ratio and clinical severity of patients with respiratory viral infection (i.e., SARS-CoV-2) due to the oxidative stress and the inflammatory response. ,, In addition, the role of PM in inducing the expression of receptor angiotensin-converting-enzyme-2 (ACE-2) may also facilitate the infection of the respiratory virus .…”

Section: Introductionmentioning

confidence: 99%

Impact of Secondary Organic Aerosol on the Respiratory Viral Infection in Vitro

Wang,

Zhang,

Lin

et al. 2024

Environ. Sci. Technol. Lett.

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Inhalation of viable airborne pathogens often leads to respiratory infections. Among the different factors that affect the survival of airborne pathogens, specific aerosol composition, such as secondary organic aerosol (SOA), may impact the severity of respiratory infection by stimulating host cell apoptotic responses. Here, we studied the in vitro effects of SOA (biogenic and anthropogenic) on respiratory infection of the human influenza A virus (H1N1). Viral gene copies in the human bronchial epithelial cell line (BEAS-2B) and human fetal lung fibroflast cell line (MRC-5) treated with SOA were measured to be significantly different from the control group. A maximum enhancement of 56%, 77%, and 45% in H1N1 replication was observed for BEAS-2B cells exposed to different doses of α-pinene SOA, toluene SOA, and naphthalene SOA, respectively. SOA from various precursors impacted viral replication differently, indicating the importance of emission source and composition. For BEAS-2B cells, anthropogenic SOA (toluene and naphthalene) significantly suppressed viral replication at low doses (1 μg mL–1 and 5 μg mL–1) and enhanced viral replication at higher doses. Interplay among the source, composition, oxidative stress, host cell apoptosis, and respiratory viral infection highlights the importance of having air pollution mitigation strategies out of a public health perspective.

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Different effects of air pollutant concentrations on influenza A and B in Sichuan, China

Li,

Zhou,

Zhang

et al. 2024

Ecotoxicology and Environmental Safety

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Stronger susceptibilities to air pollutants of influenza A than B were identified in subtropical Shenzhen, China

Cited by 4 publications

References 56 publications

The association between Ambient Temperature and Influenza Activity across 124 countries globally during 2014–2019

The association between Ambient Temperature and Influenza Activity across 124 countries globally during 2014–2019

Impact of Secondary Organic Aerosol on the Respiratory Viral Infection in Vitro

Different effects of air pollutant concentrations on influenza A and B in Sichuan, China

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