Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue

Abstract

Gluing dynamic, wet biological tissue is important in injury treatment yet difficult to achieve. Polymeric adhesives are inconvenient to handle due to rapid cross-linking and can raise biocompatibility concerns. Inorganic nanoparticles adhere weakly to wet surfaces. Herein, an aqueous suspension of guanidinium-functionalized chitin nanoparticles as a biomedical adhesive with biocompatible, hemostatic, and antibacterial properties is developed. It glues porcine skin up to 3000-fold more strongly (30 kPa) than inorganic nanoparticles at the same concentration and adheres at neutral pH, which is unachievable with mussel-inspired adhesives alone. The glue exhibits an instant adhesion (2 min) to fully wet surfaces, and the glued assembly endures one-week underwater immersion. The suspension is lowly viscous and stable, hence sprayable and convenient to store. A nanomechanic study reveals that guanidinium moieties are chaotropic, creating strong, multifaceted noncovalent bonds with proteins: salt bridges comprising ionic attraction and bidentate hydrogen bonding with acidic moieties, cation−π interactions with aromatic moieties, and hydrophobic interactions. The adhesion mechanism provides a blueprint for advanced tissue adhesives.

Gradient Modulus Tissue Adhesive Composite for Dynamic Wound Closure

“…With three or more layers of micro‐mesh, the burst pressure further increased to ≈ 650 mmHg (GmTAC3) or 890 mmHg (GmTAC5), much higher than that reported in the literature. [ 23,24,28,29 ]…”

Ultra-stretchable, Antifatigue, Adhesive, and Self-Healing Hydrogels Based on the Amino Acid Derivative and Ionic Liquid for Flexible Strain Sensors

“…43 Therefore, introducing arginine into the hydrogel system may contribute to the biocompatibility and underwater adhesion properties. 44,45 In order to construct multifunctional metal-coordinated hydrogels easily, we developed the hydrogels by introducing functional Schiff base ligands into the polymer network. 46−50 For example, we reported two self-healing and multi-stimulusresponsive hydrogels by functional Schiff base ligands.…”

“…These properties are related to its planar structure, which sterically hinders water molecules and dehydrates the surface of guanidine cations . Therefore, introducing arginine into the hydrogel system may contribute to the biocompatibility and underwater adhesion properties. , …”

Sustainable Poly(butylene adipate-co-furanoate) Composites with Sulfated Chitin Nanowhiskers: Synergy Leading to Superior Robustness and Improved Biodegradation

“…The hierarchical structure of chitin is constructed by hard rod-shaped crystals that exhibit a high degree of hydrogen bonding between acetyl and hydroxyl groups, thereby endowing it with exceptional stiffness (about 130 GPa); indeed, chitin is even stiffer than cellulose. − Chitin also possesses favorable biological characteristics: it is non-toxic, sustainable, and biodegradable and is extracted from biomass using top-down approaches that produce chitin nanomaterials as mechanical reinforcing fillers for various types of polymers. , Furthermore, the surfaces of the resulting chitin nanomaterials can be appropriately modified by exploiting the versatile nature of its amino (NH 2 ) groups. Chitin nanomaterials with desirable surface features have high dispersibilities in monomeric media and endow polymer matrices with remarkable interfacial affinities and reinforcement. , …”

“…Chitin nanomaterials with desirable surface features have high dispersibilities in monomeric media and endow polymer matrices with remarkable interfacial affinities and reinforcement. 53,54 Herein, we present all-biobased PBAF composites that incorporate sulfated chitin nanowhiskers (SCHWs) prepared through in situ polymerization. The mechanical properties of the PBAF composites are superior to those of PBAT and other conventional biobased composites, which is attributable to superior SCHW dispersibility in the monomer reaction medium.…”