Strong hydrophilic monolithic column functionalized with amphiphilic benzyl quinine for capillary electrochromatography and application in pharmaceutical analysis

Mao, Zhenkun; Li, Zhentao; Hu, Changjun; Liu, Yikun; Cao, Zhi; Chen, Zilin

doi:10.1016/j.chroma.2020.461031

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…A polyhedral oligomeric siloxane‐based zwitterionic monolithic capillary column was prepared via one‐pot polymerization in ionic liquid porogen, using N , N‐ dimethyl‐ N‐ methacryloxyethyl‐ N‐ (3‐sulfopropyl)ammonium betaine and methacrylic ethyl trimethylammonium chloride as binary functional monomers, and methacryl substituted polyhedral oligomeric siloxane as cross‐linker [31]. A strong hydrophilic monolithic column of poly( N‐ benzylquininium chloride‐co‐1,3,5‐triacryloylhexahydro‐1,3,5‐triazine) has been successfully synthesized through in situ copolymerization for CEC [32]. The monolithic column displayed a hydrophilic retention mechanism with a mobile phase containing more than 60% organic solvent.…”

Section: Introductionmentioning

confidence: 99%

Preparation of poly(N‐vinylpyrrolidone‐co‐pentaerythritol triacrylate) monolithic column for hydrophilic interaction chromatography

Qiu

et al. 2023

J of Separation Science

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A method for the preparation of poly(N-vinylpyrrolidone-co-pentaerythritol triacrylate copolymerization)-based monolithic capillary column was reported for the separation of polar small molecular weight compounds with nano-liquid chromatography in hydrophilic interaction chromatography mode. The monolithic columns were prepared by in situ copolymerization of N-vinylpyrrolidone and a cross-linker pentaerythritol triacrylate in a binary porogenic agent consisting of methanol and water. The composition of the polymerization solution was systematically optimized in terms of column permeability, theoretical plate number, asymmetric factor, and retention factor. A typical hydrophilic chromatography retention mechanism was observed with a mobile phase composed of a high content of organic solvent. The preparation method is simple and robust, the precursor N-vinylpyrrolidone is chemically stable, cheap, and easily available. The N-vinylpyrrolidone-based hydrophilic interaction chromatography stationary phase displays satisfactory separation selectivity for a range of polar test analytes, including benzoic acid derivatives, nucleosides, and phenols.

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Section: Introductionmentioning

confidence: 99%