Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases

Wafer-scale silver nanodendrites with homogeneous distribution of gold nanoparticles for biomolecules detection

“…Surface-enhanced Raman spectroscopy/scattering (SERS) is one of the most fascinating analytic techniques for rapid, in-field, single-shot detection of analyte molecules finding impending applications in biomedicine, clinical, environmental detection, food safety, and so forth. ( Vendamani et al, 2022 ; Verma and Soni, 2022 ; Tzeng and Lin, 2020 ; Zhang et al., 2013 ; Powell et al., 2017 ; Ouyang et al., 2018 ; Xu et al., 2018 ; Zhu et al., 2021 ). This technique has also been favored in food inspection via examining antibiotic deposits in animal products ( Lirio et al., 2016 ; Li et al., 2015 ).…”

Strong Out-of-Plane Vibrations and Ultrasensitive Detection of Dopamine-like Neurotransmitters

“…10 Low-intensity high-frequency Raman bands (>200 cm −1 ) of some monoamine neurotransmitters have been acquired in previous studies, and few have been applied in disease detection. 11 Our recent research shows that the low-frequency Raman spectrum of histamine molecules in the wavenumber range of <200 cm −1 is significantly stronger than the high-frequency spectrum and can be used in a highprecision probe of histamine concentration. 11 In this work, we carefully examine the low-frequency Raman spectra of four kinds of monoamine neurotransmitters, DA, NE, EE, and 5HT, and find them to have strong intensities and high specificities.…”

“…11 Our recent research shows that the low-frequency Raman spectrum of histamine molecules in the wavenumber range of <200 cm −1 is significantly stronger than the high-frequency spectrum and can be used in a highprecision probe of histamine concentration. 11 In this work, we carefully examine the low-frequency Raman spectra of four kinds of monoamine neurotransmitters, DA, NE, EE, and 5HT, and find them to have strong intensities and high specificities. Similar results occur when they exist in solution environments such as CSF.…”

“…8 an important bioactive small molecule, has also been reported to have similar phenomena (Figure S1 in the Supporting Information). 11 All of these molecules consist of a ringed group and a carbon side chain, so the strong low-frequency Raman spectra should be related to similar molecular structures (Figure S2 in the Supporting Information). It is known that histamine has two nitrogen atoms in the imidazole ring and one nitrogen atom in the side chain.…”

“…Such a molecular structure makes high electron density distributions concentrated on three areas, two being on the C atoms of the ring and one being on the side chain, and only torsions of the C−C bonds in the side chain can dramatically cause electron density changes of the three areas to produce a great molecular polarizability modification. 11 This is the reason that causes the observed strong low-frequency Raman peaks in histamine. For DA, NE, EE, and 5HT, they have a similar ringed structure, but some oxygen atoms (two for DA, NE, and EE, and one for 5HT) bond to the C ring to form the C−O bonds (Figure 1a).…”