Strong exercise stress exacerbates dermatitis in atopic model mice, NC/Nga mice, while proper exercise reduces it

Abstract

Atopic dermatitis is well known to exacerbate by stress. How the influence of exercise stress on the skin symptoms in patients with atopic dermatitis has not been clarified. The purpose of our research is to investigate how different strength of exercise stress acts on atopic dermatitis. Specific pathogen-free (SPF) and conventional NC/Nga male mice were used for the experiments. Conventional mice but not SPF group spontaneously develop dermal symptom similar to that of patients with atopic dermatitis at their age of 7 weeks. They were given two types of stress, mild (20 m/min for 60 min) or strong exercise (25 m/min for 90 min), using a treadmill four times per day. The dermal symptom of the conventional group was strongly exacerbated by strong exercise but ameliorated by mild exercise. Under the standard experimental conditions, plasma concentrations of α-melanocyte-stimulating hormone (α-MSH), transforming growth factor-β (TGF-β) and substance P in conventional mice increased markedly with concomitant exacerbation of the symptom. The plasma concentrations of these proteins elevated after strong exercise but decreased after mild exercise. Under the conventional conditions, plasma levels of β-endorphin increased with time by some mechanisms enhanced by the mild exercise. These observations suggested that exercise-induced stress significantly affect the symptom of atopic dermatitis in a pivotal manner depending on the plasma levels of TGF-β, α-MSH, substance P and β-endorphin.

Skin Hydrating Effects of <i>Corchorus olitorius</i> Extract in a Mouse Model of Atopic Dermatitis

“…In the aggravation of atopic dermatitis in NC/Nga mice, COEW does not seem to affect the plasma IgE concentrations. In the recent study, while the AD score was suppressed in conventional NC/Nga mice, plasma IgE concentrations was maintained to high levels [20], which phenomenon supports our data.…”

Dariers disease and pregnancy

“…The plasma level of β-End was found to be increased in mice with a mild stress load [9]. This suggested the possibility that β-End contributed to the reduction of the AD-like symptoms.…”

“…Furthermore, it has been suggested that there are relationships among AD, β-End and allergies [7,8]. In our previous study using NC/Nga mice, we showed that AD-like symptoms were exacerbated by strong stress and reduced by mild stress [9].…”

Fungus as an Exacerbating Factor of Atopic Dermatitis, and Control of Fungi for the Remission of the Disease

“…Allergic diarrhea was induced by repeated intragastric administration of ovalbumin in BALB/c mice. Contact hypersensitivity was evaluated by measuring ear swelling after topical application of 2, 4-dinitrofluorobenzene in NC/Nga mice, which are often used as a mouse model of AD (Jin et al, 2011;Orita et al, 2010). Arthritis was induced by intradermal injection of bovine type-II collagen emulsified with complete Freund's adjuvant in DBA/1J mice.…”