Strong corrosion induced by carbon nanotubes to accelerate Fe biodegradation

Shuai, Cijun; Li, Sheng; Wang, Guoyong; Peng, Shuping; Gao, Chengde

doi:10.1016/j.msec.2019.109935

Cited by 22 publications

(13 citation statements)

References 55 publications

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“…The electrochemical behaviors of Fe/Mg 2 Si composites were tested by an IM6 electrochemical workstation (Zahner, Germany) in simulated body fluid (SBF) at 37°C. The SBF with a pH of 7.4 contained 8.035 g·L −1 NaCl, 0.225 g·L −1 KCl, 0.311 g·L −1 MgCl 2 ·6H 2 O, 0.231 g·L −1 K 2 HPO 4 ·3H 2 O, 6.118 g·L −1 (CH 2 OH) 3 CNH 2 , 0.355 g·L −1 NaHCO 3 , 0.292 g·L −1 CaCl 2 , and 0.072 g·L −1 Na 2 SO 4 [ 2 , 35 ]. The typical three-electrode cell, containing the saturated calomel electrode (SCE, reference electrode), the sample (working electrode), and the platinum electrode (auxiliary electrode), was used to perform electrochemical tests.…”

Section: Methodsmentioning

confidence: 99%

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Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

Shuai

Peng

et al. 2020

IJB

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Fe is regarded as a promising bone implant material due to inherent degradability and high mechanical strength, but its degradation rate is too slow to match the healing rate of bone. In this work, hydrolytic expansion was cleverly exploited to accelerate Fe degradation. Concretely, hydrolyzable Mg2Si was incorporated into Fe matrix through selective laser melting and readily hydrolyzed in a physiological environment, thereby exposing more surface area of Fe matrix to the solution. Moreover, the gaseous hydrolytic products of Mg2Si acted as an expanding agent and cracked the dense degradation product layers of Fe matrix, which offered rapid access for solution invasion and corrosion propagation toward the interior of Fe matrix. This resulted in the breakdown of protective degradation product layers and even the direct peeling off of Fe matrix. Consequently, the degradation rate for Fe/Mg2Si composites (0.33 mm/y) was significantly improved in comparison with that of Fe (0.12 mm/y). Meanwhile, Fe/Mg2Si composites were found to enable the growth and proliferation of MG-63 cells, showing good cytocompatibility. This study indicated that hydrolytic expansion may be an effective strategy to accelerate the degradation of Fe-based implants.

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Section: Methodsmentioning

confidence: 99%

“…Meanwhile, the composition analysis of corrosion products was performed by EDS. The degradation rates of samples were calculated according to the methods in the literature[ 35 ].…”

Section: Methodsmentioning

confidence: 99%

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

Shuai

Peng

et al. 2020

IJB

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“…The less stable form of Fe (III) hydroxides was further transformed into a more stable compound such as Fe oxide-hydroxide and it can be observed from XRD plot (refer to Figure 6E). 40,45 Moreover, the hypoxia condition in the incubator was also found responsible for undergoing an anaerobic reaction that transforms Fe (III) hydroxides into magnetite. 40,45 The release of Fe ions during anaerobic reaction caused an increase in the surrounding pH value and encourage the precipitation of phosphate and bicarbonate ions.…”

Section: Static In Vitro Degradation Behaviormentioning

confidence: 99%

“…40,45 Moreover, the hypoxia condition in the incubator was also found responsible for undergoing an anaerobic reaction that transforms Fe (III) hydroxides into magnetite. 40,45 The release of Fe ions during anaerobic reaction caused an increase in the surrounding pH value and encourage the precipitation of phosphate and bicarbonate ions.…”

Section: Static In Vitro Degradation Behaviormentioning

confidence: 99%

Corrosion behavior and degradation mechanism of micro‐extruded 3D printed ordered pore topological Fe scaffolds

Mishra

Pandey

2022

J Biomed Mater Res

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The fabrication of ordered pore topological structures (OPTS) with an improved biodegradation profile offers unique attributes required for bone reconstruction. These attributes consisted of fully interconnected porous structure, bone‐mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most of the biomaterials based on magnesium were associated with the problem of too fast degradation rate. Here, the present aim was based on the fabrication of ordered pore topological Fe structures (OPTFS) using micro‐extrusion‐based 3D printing followed by pressureless microwave sintering. Two different kinds of pore features namely randomly distributed interconnected micropores and designed interconnected macropores were investigated. Static in vitro degradation results inferred that the H‐2 mm pore size of hexagonal based ordered pore topological Fe structures (H‐OPTFS) exhibited the highest degradation rate of 6.45 mg cm−2 day−1 on the 28th day. Electrochemical results revealed that the corrosion current density of the T‐1 Fe sample with 44% porosity increased nearly by a multiple of three times as compared to dense Fe (from 16.79 to 44.63 . Similarly, these results showed more significance in H‐2 mm pores size (with highest 66% porosity) of H‐OPTFS as compared to H‐1.75 mm and H‐1.5 mm pore size of H‐OPTFS (≈2 times higher degradation rate than H‐1.5 mm pore size). Moreover, the MG63 osteoblast cell line was adhered to and proliferated significantly throughout the surface and illustrated more than 80% cell viability of the prepared porous Fe scaffold. The analyzed results have shown the potential of fabricated OPTFS could be considered for biomedical applications.

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“…More significantly, it possesses a high specific surface area, which can increase area ratio between the cathode and anode [19]. Previous studies confirmed that an increased area ratio of cathode and anode could enhance the galvanic corrosion effect [20][21][22]. Moreover, MC has excellent electrical conductivity, which can decrease the electron transfer resistance and increase corrosion current density [23,24].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Carbon as Galvanic-Corrosion Activator Accelerates Fe Degradation

Shuai

Deng

et al. 2020

Applied Sciences

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Iron (Fe) has attracted intensive attention as a bone implant material because of its inherent biodegradability, favorable biocompatibility and mechanical properties. Nevertheless, it degrades too slowly in a physiological environment, which limits its further clinical application. In this work, mesoporous carbon (MC) was introduced into Fe bone implant manufactured via a laser-additive manufacturing process. Particularly, MC possesses a noble standard corrosion potential and excellent electrical conductivity, thus acting as an effective cathode and activating micro-galvanic corrosion in the Fe matrix. More importantly, its high specific surface area enhanced the area ratio between cathode and anode, which further enhanced the galvanic corrosion effect. As a consequence, the corrosion rate was enhanced from 0.09 to 0.24 mm/year based on immersion tests. Besides, Fe/MC composite exhibited good cytocompatibility, as well as excellent mechanical properties. The positive results proved that the Fe/MC composite shows great potential as a bone implant.

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Strong corrosion induced by carbon nanotubes to accelerate Fe biodegradation

Cited by 22 publications

References 55 publications

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

Corrosion behavior and degradation mechanism of micro‐extruded 3D printed ordered pore topological Fe scaffolds

Mesoporous Carbon as Galvanic-Corrosion Activator Accelerates Fe Degradation

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