Strong correlation between early stage atherosclerosis and electromechanical coupling of aorta

Liu, X. Y.; Yan, Fei; Niu, Lili; Chen, Qian Nataly; Zheng, Hairong; Li, J. Y.

doi:10.1039/c5nr07398g

Cited by 8 publications

(11 citation statements)

References 41 publications

(38 reference statements)

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“…Another interesting observation is the strong correlation between early stage atherosclerosis and electromechanical coupling of aorta was recently reported (Liu et al 2016). Atherosclerosis is the underlying cause of cardiovascular diseases (Lusis 2000), and the existing imaging methods are not capable of detecting the early stage of atherosclerosis development due to their limited spatial resolution (Nakashima, Wight, and Sueishi 2008).…”

Section: Bio-chemo-electro-mechanical Behavior Revealed By Piezomentioning

confidence: 67%

The coupled bio-chemo-electro-mechanical behavior of glucose exposed arterial elastin

Zhang¹,

Li²,

Boutis³

2017

J. Phys. D: Appl. Phys.

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Elastin, the principle protein component of the elastic fiber, is a critical extracellular matrix (ECM) component of the arterial wall providing structural resilience and biological signaling essential in vascular morphogenesis and maintenance of mechanical homeostasis. Pathogenesis of many cardiovascular diseases have been associated with alterations of elastin. As a long-lived ECM protein that is deposited and organized before adulthood, elastic fibers can suffer from cumulative effects of biochemical exposure encountered during aging and/or disease, which greatly compromise their mechanical function. This review article covers findings from recent studies of the mechanical and structural contribution of elastin to vascular function, and the effects of biochemical degradation. Results from diverse experimental methods including tissue-level mechanical characterization, fiber-level nonlinear optical imaging, piezoelectric force microscopy, and nuclear magnetic resonance are reviewed. The intriguing coupled bio-chemo-electro-mechanical behavior of elastin calls for a multi-scale and multi-physical understanding of ECM mechanics and mechanobiology in vascular remodeling.

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Section: Bio-chemo-electro-mechanical Behavior Revealed By Piezomentioning

confidence: 67%

The coupled bio-chemo-electro-mechanical behavior of glucose exposed arterial elastin

Zhang¹,

Li²,

Boutis³

2017

J. Phys. D: Appl. Phys.

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“…Muscle Actin and myosin [18] Hair Keratin [16] Bone Collagen [32] Tendon Collagen [33] Lung tissue Elastin [34] Skin (dermis) Collagen [28] Skin (horny layer and epidermis) Keratin [28] Breast tissue Collagen [35] Outer hair cell Prestin [36] detection of atherosclerosis in the aorta, however as mentioned in a prior paragraph the validity of the aorta's piezoelectric nature is still under debate [48]. In this paper, they claimed the PFM amplitude increased as a function of advancing atherosclerosis and could help with early detection of the disease.…”

Section: Organ Piezoelectric Moleculementioning

confidence: 99%

Piezoelectric Materials for Medical Applications

Chen-Glasser¹,

Li²,

Ryu³

et al. 2018

Piezoelectricity - Organic and Inorganic Materials and Applications

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This chapter describes the history and development strategy of piezoelectric materials for medical applications. It covers the piezoelectric properties of materials found inside the human body including blood vessels, skin, and bones as well as how the piezoelectricity innate in those materials aids in disease treatment. It also covers piezoelectric materials and their use in medical implants by explaining how piezoelectric materials can be used as sensors and can emulate natural materials. Finally, the possibility of using piezoelectric materials to design medical equipment and how current models can be improved by further research is explored. This review is intended to provide greater understanding of how important piezoelectricity is to the medical industry by describing the challenges and opportunities regarding its future development.

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“…19 However, despite the "near-ubiquitous presence of piezoelectricity in biological systems," 20 there has been very limited evidence for ferroelectricity, especially in soft tissues. The first reports of a ferroelectric response in porcine aortic walls by means of piezoresponse force microscopy (PFM) [21][22][23][24] were therefore surprising. PFM detects the local deformation of a sample caused by an applied electric field from the tip of the cantilever of a scanning force microscope.…”

mentioning

confidence: 99%

“…Our global strain measurements on aortic walls are at variance with reported PFM measurements. [21][22][23][24] Piezoresponse force microscopy is a powerful tool and well-established in the ferroelectric community. 25,26,[48][49][50][51] However, it was demonstrated to be prone to artifacts.…”

mentioning

confidence: 99%

Ferroelectricity and piezoelectricity in soft biological tissue: Porcine aortic walls revisited

Lenz

Hummel

Katsouras

et al. 2017

Applied Physics Letters

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Recently reported piezoresponse force microscopy (PFM) measurements have proposed that porcine aortic walls are ferroelectric. This finding may have great implications for understanding biophysical properties of cardiovascular diseases such as arteriosclerosis. However, the complex anatomical structure of the aortic wall with different extracellular matrices appears unlikely to be ferroelectric. The reason is that a prerequisite for ferroelectricity, which is the spontaneous switching of the polarization, is a polar crystal structure of the material. Although the PFM measurements were performed locally, the phase-voltage hysteresis loops could be reproduced at different positions on the tissue, suggesting that the whole aorta is ferroelectric. To corroborate this hypothesis, we analyzed entire pieces of porcine aorta globally, both with electrical and electromechanical measurements. We show that there is no hysteresis in the electric displacement as well as in the longitudinal strain as a function of applied electric field and that the strain depends on the electric field squared. By using the experimentally determined quasi-static permittivity and Young's modulus of the fixated aorta, we show that the strain can quantitatively be explained by Maxwell stress and electrostriction, meaning that the aortic wall is neither piezoelectric nor ferroelectric, but behaves as a regular dielectric material.

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Strong correlation between early stage atherosclerosis and electromechanical coupling of aorta

Cited by 8 publications

References 41 publications

The coupled bio-chemo-electro-mechanical behavior of glucose exposed arterial elastin

The coupled bio-chemo-electro-mechanical behavior of glucose exposed arterial elastin

Piezoelectric Materials for Medical Applications

Ferroelectricity and piezoelectricity in soft biological tissue: Porcine aortic walls revisited

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