Strong correlation between diet and development of colorectal cancer

Cappellani, Alessandro; Zanghì, Antonio; Vita, Maria Di; Cavallaro, Andrea; Piccolo, Gaetano; Veroux, Massimiliano; E, Lo Menzo; Cavallaro,; Paoli, Paolo De; Berretta, Massimiliano

doi:10.2741/4095

Cited by 35 publications

(12 citation statements)

References 85 publications

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“…This proves the statement in introduction that the results of studies in fiber are equivocal, because there are conflicting evidences for effects of dietary fiber role in cancer protection [40]. One of the other ways dietary fibers may protect against colorectal cancer is by adsorbing carcinogens and carrying them out of the digestive tract, thus lessening interaction of the carcinogens with the colonic tissue [41]; for instance, fiber enhances de-conjugation of bile acids [42].…”

Section: Introduction To Different Types Of Dietary Fiber and Associmentioning

confidence: 83%

The Role of Soluble, Insoluble Fibers and Their Bioactive Compounds in Cancer: A Mini Review

Papandreou¹,

Noor²,

Rashed³

2015

FNS

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The cancer incidence has risen dramatically over the last decades. About 8 million people died globally according to latest reports, which represented almost 40% more than it was 20 years ago. Risk factors for the development of cancer have been found to include smoking, alcohol, drugs, obesity and diet. Fiber intake has shown to exhibit chemoprotective effects on cancer proliferation and metastasis that may seem to be very promising. This article will review the role of different types of fiber such as, cellulose, lignin, pectin and inulin in development and prevention of different types of cancers. This article would also discuss the effectiveness of both types of fiber in cancer prevention.

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Section: Introduction To Different Types Of Dietary Fiber and Associmentioning

confidence: 83%

The Role of Soluble, Insoluble Fibers and Their Bioactive Compounds in Cancer: A Mini Review

Papandreou¹,

Noor²,

Rashed³

2015

FNS

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“…The direction of effect among females was similar; however, HRs were only statistically significant for moderately differentiated tumours and tumours with no lymph node involvement. Previously, individual food groups, micronutrients, and macronutrients have been associated with increases or decreases in CRC risk including red and processed meat, fibre, vitamin D, animal fat, and selenium (33; 34) . For example, excessive alcohol consumption has been shown to increase CRC by 8-52%, which is generally stronger among males than females (33) ; excessive or no alcohol consumption also has been associated with increased inflammation compared to moderate consumption (35) .…”

Section: Discussionmentioning

confidence: 99%

The dietary inflammatory index is associated with colorectal cancer in the National Institutes of Health–American Association of Retired Persons Diet and Health Study

et al. 2015

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Diet is a strong moderator of systemic inflammation, an established risk factor for colorectal cancer (CRC). The Dietary Inflammatory Index (DII) measures the inflammatory potential of individuals' diets. The association between the DII and incident CRC was examined using the National Institutes of Health-American Associations of Retired Persons Diet and Health Study individuals (n=489,422) aged 50-74 years at recruitment, starting between 1995-1996, and followed for a mean of 9.1(±2.9) years. Baseline data from a food frequency questionnaire were used to calculate the DII; higher scores are more pro-inflammatory and lower scores are more anti-inflammatory. First primary CRC diagnoses were identified through linkage to state cancer registries. Anatomic location and disease severity also were examined. Cox proportional hazards models estimated CRC hazard ratios (HRs) and 95% confidence intervals (95%CI) using quartile 1 as the referent. DII quartile 4 compared to 1 was associated with CRC risk among all subjects (HR=1.40; 95%CI=1.28-1.53, p-value for trend <0.01). Statistically significant associations also were observed for each anatomic site examined, for moderate and poorly differentiated tumours, and at each cancer stage among all subjects. Effects were similar when stratified by sex; however, results were statistically significant only in males. The only result reaching statistical significance in females was risk of moderately differentiated CRC tumours (DII quartile 4 vs. 1 HR=1.26; 95%CI=1.03-1.56). Overall, the DII was associated with CRC risk among all subjects. The DII may serve as a novel way to evaluate dietary risk for chronic disorders associated with inflammation, such as CRC.

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“…The high adherence to MD, as evidenced by studies on different groups of individuals, lead to a reduction of mortality and the incidence of major chronic diseases [23,25], such as cancer [26,27,28], metabolic and cardiovascular syndrome [29], neurodegenerative diseases [30], type 2 diabetes [31,32], fatty liver diseases [33] and allergy [34]. Moreover, MD is highly associated with an improved quality of life, which is translated into better psycho/physiological and metabolic profiles [35,36] (Figure 2).…”

Section: MD and Diet Effects On Disease Riskmentioning

confidence: 99%

Mediterranean Diet and Health: Food Effects on Gut Microbiota and Disease Control

Chierico

Vernocchi

Dallapiccola

et al. 2014

IJMS

166

112

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The Mediterranean diet (MD) is considered one of the healthiest dietary models. Many of the characteristic components of the MD have functional features with positive effects on health and wellness. The MD adherence, calculated through various computational scores, can lead to a reduction of the incidence of major diseases (e.g., cancers, metabolic and cardiovascular syndromes, neurodegenerative diseases, type 2 diabetes and allergy). Furthermore, eating habits are the main significant determinants of the microbial multiplicity of the gut, and dietary components influence both microbial populations and their metabolic activities from the early stages of life. For this purpose, we present a study proposal relying on the generation of individual gut microbiota maps from MD-aware children/adolescents. The maps, based on meta-omics approaches, may be considered as new tools, acting as a systems biology-based proof of evidence to evaluate MD effects on gut microbiota homeostasis. Data integration of food metabotypes and gut microbiota “enterotypes” may allow one to interpret MD adherence and its effects on health in a new way, employable for the design of targeted diets and nutraceutical interventions in childcare and clinical management of food-related diseases, whose onset has been significantly shifted early in life.

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Strong correlation between diet and development of colorectal cancer

Cited by 35 publications

References 85 publications

The Role of Soluble, Insoluble Fibers and Their Bioactive Compounds in Cancer: A Mini Review

The Role of Soluble, Insoluble Fibers and Their Bioactive Compounds in Cancer: A Mini Review

The dietary inflammatory index is associated with colorectal cancer in the National Institutes of Health–American Association of Retired Persons Diet and Health Study

Mediterranean Diet and Health: Food Effects on Gut Microbiota and Disease Control

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