Strong association of Torque teno virus/Torque teno-like minivirus to Kikuchi-Fujimoto lymphadenitis (histiocytic necrotizing lymphadenitis) on quantitative analysis

Chong, Yosep; Lee, Ji Young; Thakur, Nishant; Kang, Chang Suk; Lee, Eun Jung

doi:10.1007/s10067-019-04851-4

Cited by 14 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, some children tested positive for pathogens, including streptococcus, adenovirus, and the EB, parainfluenza, mycoplasma, herpes simplex, and respiratory syncytial viruses which are consistent with previous studies. 6 , 7 At present, the cause of the disease has not been fully understood. It is generally believed that lymph node necrosis is an excessive immune response mediated by T cells under the stimulation of pathogens instead of being directly caused by viruses and pathogens.…”

Section: Discussionmentioning

confidence: 99%

Clinical Analysis of 44 Children with Subacute Necrotizing Lymphadenitis

Zheng¹,

Du²,

Zhu³

et al. 2022

IDR

View full text Add to dashboard Cite

Objective To explore the causes, clinical features, and laboratory examination characteristics of subacute necrotizing lymphadenitis to improve the understanding of this disease, reduce misdiagnosis, and make appropriate diagnoses and treatments. Methods The clinical data of 44 children with subacute necrotizing lymphadenitis admitted to our hospital from January 2013 to August 2021 were collected. The clinical and laboratory examinations of the disease were systematically analyzed. Results All 44 cases aged 6–13 years and averaged 10.3 ± 2.1 years, including 32 boys and 12 girls, were diagnosed with histiocytic necrotizing lymphadenitis (HNL) by lymph node biopsy. Forty-two cases had palpable superficial lymph nodes, and two showed abdominal lymph node enlargement in the imaging examination. The symptoms might be accompanied by mild hepatomegaly or splenomegaly, emaciation, night sweats, rashes, and other manifestations. Leukopenia and neutropenia occurred. The pathological features were extensive coagulative necrosis of lymph nodes with reactive hyperplasia of histiocytes as well as positive IHCl CD68. Four cases had a relapse, and the prognosis of the other cases was good. Conclusion The case with fever and lymph node enlargement of unknown origin and no response to antibiotic treatment should undergo a pathological examination as early as possible for diagnosis and treatment. The disease has a good prognosis in most cases but may recur in a few cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Analysis of 44 Children with Subacute Necrotizing Lymphadenitis

Zheng¹,

Du²,

Zhu³

et al. 2022

IDR

View full text Add to dashboard Cite

show abstract

“…This would be consistent with the paradigm that KFD needs an infectious trigger to develop but requires a specific HLA to develop disease. Although multiple offenders have been identified including Epstein Barr Virus, various Human Herpes Viruses, HIV, Torque Teno virus and Toxoplasma Gondii, it remains largely unclear if these pathogens are etiological or more likely inflammatory drivers of disease through TLR or other innate receptors [4,[8][9][10].…”

Section: Discussionmentioning

confidence: 99%

A familial case of Kikuchi-Fujimoto disease in dizygotic twins

et al. 2020

View full text Add to dashboard Cite

Background: Kikuchi-Fujimoto disease (KFD) or necrotizing histiocytic lymphadenitis, was described separately by both Kikuchi and Fujimoto in Japan in the early 1970's. Despite its rarity in the pediatric population, it is an important differential in persistent lymphadenopathy. Familial cases of KFD in the literature are rare. Here we describe the first reported case of KFD in non-identical twin sisters. Case presentation: Twin 1 presented with a 3-week history of worsening right-sided cervical lymphadenopathy, daily fevers, significant lethargy, weight loss and arthralgia of her knees and ankles at the age of 12 years in 2015. She had had an unremarkable medical history. A biopsy of her lymph nodes showed histiocytic necrosis consistent with KFD. Twin 2 presented with a three-week history of lethargy, fatigue, weight loss and left-sided posterior cervical chain lymphadenopathy at 16 years of age in 2018. She had a history of frequently relapsing nephrotic syndrome and celiac disease. A biopsy of her lymph nodes was undertaken and showed histiocytic necrosis consistent with KFD. Conclusions: KFD is a rare but self-limiting pathological process of necrotizing histiocytic lymphadenitis. Although further research is needed, there is an increasing amount of evidence which suggests a multifactorial pathological basis of disease. The two cases we document here are the first reported cases of familial KFD in dizygotic HLAidentical twins which reinforces the likely HLA-linkage in the etiology of KFD.

show abstract

“…Kikuchi-Fujimoto disease (KFD) is a rare, benign disease, presenting with lymphadenopathy, frequently associated with a series of systemic manifestations such as fever, cutaneous eruptions, cytopenia and so on [5]. The aetiology of KFD remains unclear, and may associate with viral infection or autoimmune diseases [6] [7] [8] [9]. The pathogenesis of KFD, may involve the activation of CD8+ T cell, leads to T cell proliferation and dying via the Fas and perforin pathways; then, macrophages phagocytic apoptotic cells, and resulting in typical necrotizing lymphadenitis [10].…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease with Hemophagocytic Syndrome and Pleural Effusion in an Elder Man: A Case Report and Literature Review

Zhang¹,

Deng²

2020

CRCM

View full text Add to dashboard Cite

Background: Kikuchi-Fujimoto disease (KFD), also named Histiocytic necrotizing lymphadenitis (HNL), is a rare and self-limited necrotizing lymphadenitis, most commonly affects young Asian female. KFD is characterized by lymphadenopathy, cytopenia, fever, rashes, and weight loss, however, hemophagocytic syndrome and pleural effusion are rarely reported. Case Presentation: We present the case of a 61-year-old man with clinical features including fever, lymphadenopathy, purpura, arthralgia, pleural effusion and pulmonary infection. He had cervical lymphnodebiopsy and the pathology is consistent with KFD, laboratory tests and clinical manifestations were consistent with hemophagocytic syndrome (HLH). After initial treatment including corticosteroid and anti-infection drugs, the patient showed improvement but soon deteriorated. Conclusion: KFD is a self-limited disease with spontaneous resolution. However, the cases of KFD with HLH may have a fatal course. Early appropriate intensive immunosuppressive therapy and strong anti-infection therapy could be beneficial for the treatment outcome.

show abstract

Strong association of Torque teno virus/Torque teno-like minivirus to Kikuchi-Fujimoto lymphadenitis (histiocytic necrotizing lymphadenitis) on quantitative analysis

Cited by 14 publications

References 25 publications

Clinical Analysis of 44 Children with Subacute Necrotizing Lymphadenitis

Clinical Analysis of 44 Children with Subacute Necrotizing Lymphadenitis

A familial case of Kikuchi-Fujimoto disease in dizygotic twins

Kikuchi-Fujimoto Disease with Hemophagocytic Syndrome and Pleural Effusion in an Elder Man: A Case Report and Literature Review

Contact Info

Product

Resources

About