Strong association between HLA DRw9 and Hashimoto's thyroiditis in Southern Chinese

Hawkins, B. R.; Lam, Karen S.L.; C., J. T.; Wang, C.; Yeung, Raymond W.

doi:10.1530/acta.0.1140543

Cited by 63 publications

(31 citation statements)

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“…The stronger association with DR9 is interesting, since preliminary results from our populations have shown stronger associations with B46 for de novo Graves disease 14 and DR9 for de novo Hashimoto thyroiditis. 15 It is likely that a variety of auto-antibodies coexist, and changes in immune environment or dominant T-cell population may trigger a shift in the balance between hyper-and hypothyroidism. It is interesting to compare the collection of published case reports with our single center experience.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation

Lie

Kung

et al. 2005

Bone Marrow Transplant

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Summary:Autoimmune thyroid disease (AITD) may occur in patients after hematopoietic stem cell transplantation (HSCT). In all, 10 cases of AITD (seven allogeneic and three autologous HSCT) were diagnosed among 721 HSCT recipients, including two patients with sequential hyper-and hypothyroidism. The 5-year actuarial rates for AITD after allogeneic and autologous HSCT were 2.9 and 4%, respectively. Significant risk factors included HSCT for chronic myeloid leukemia, the HLA B46 and DR9 loci and the A2B46DR9 haplotype, while female donors showed trend to significance. On multivariate analysis, only female donors and HLA DR9 remained significant. For autologous HSCT, the associations with HLA B46 and DR9 were also significant. Only three donors had a family history of AITD. A review of other reported cases confirmed the predominance of female donors, although the other associations including graftversus-host disease, familial AITD and other autoimmune phenomena might be related to reporting bias. Since the actuarial incidence of AITD from female donors with predisposing HLA alleles may be over 30%, susceptible recipients should be carefully monitored. Owing to the small number of reported cases and different HLA associations with AITD in different populations, our observations await confirmatory data from other registries.

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Section: Discussionmentioning

confidence: 99%

Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation

Lie

Kung

et al. 2005

Bone Marrow Transplant

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“…Transracial studies have been useful in determining susceptibility genes in some autoimmune disorders but have not yet been conducted in sufficient detail to clarify the HLA associations in autoimmune thyroiditis. HLA-Bw46 and DR9 are increased in Chinese patients with Hashimoto's thyroiditis (Hawkins et al, 1987;Wang et al, 1988), whereas in Japanese, B16 is increased and DR2 is decreased (Nakao et al, 1978;Sakurami et al, 1982): DR3 is unknown in healthy Japanese subjects. In a more recent report from Japan, the most impressive association was with a supertypic allele, HLA-DRw53, encoded by the DRB4 gene present only on a restricted number of haplotypes (DR4,7 and 9), the association with DR9 being much weaker (Honda et al, 1989).…”

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confidence: 94%

Autoimmune thyroiditis: predisposition and pathogenesis

Weetman

1992

Clinical Endocrinology

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IntroductionAutoimmune thyroid disease is common, affecting approximately 1% of the population while subclinical, focal thyroiditis and/or circulating thyroid autoantibodies can be found in about 15% of otherwise healthy subjects who are euthyroid. This frequency, combined with historical precedence, ready h e s s to the target organ and well established animal models, has led to a considerable research effort aimed at understanding the initiation and pathogenesis of thyroid autoimmunity, often with the hope that the lessons learned may be applicable to more serious but less accessible autoimmune diseases. In this review, I shall summarize recent developments in autoimmune hypothyroidism (Hashimoto's thyroiditis and primary myxoedema), only touching on the important insights gained from experimental autoimmune thyroiditis (EAT) and other animal models, detailed elsewhere (Weetman, 1991). Similar autoimmune processes occur in Graves' disease, which is uniquely distinguished by the presence of thyroid stimulating antibodies. These and other types of TSH receptor antibody are discussed in a separate review (Munro, 1992) and therefore will not be considered further here. PredispositionAs in many autoimmune disorders, it is the interplay of genetics and environment which determines the initiation of autoimmune thyroiditis, with a further modifying influence provided by endogenous factors such as age and sex hormones. lmmunogenetic factorsHLA-linked genes The major histocompatibility complex (MHC) of genes, called HLA in man, controls (in part) immune responsiveness to a variety of foreign and self antigens. In many autoimmune conditions, associations have been reported with certain MHC alleles, particularly those encoded by the class I (HLA-A,B,C) and class I1 (HLA-D) regions. On the whole, such associations tend to be stronger with class I1 than class I region genes. Many of the alleles within and between these regions are in linkage disequilibrium, that is, closely linked genes occur together more frequently than expected with random distribution. It is therefore difficult to determine from population-based surveys whether associations of a n autoimmune disease with a particular allele are truly an effect of this allele rather than one in linkage disequilibrium with it. To complicate matters, HLA genes have been renamed recently. A clear exposition of the old and new terminology can be found elsewhere (Tait &Harrison, 1991). As most analyses of HLA in thyroiditis to date have used serologically defined specificities, this nomenclature will be preserved below.Initial studies showed a n association of primary myxoedema with HLA-B8 in Caucasians, but none between class I region genes and Hashimoto's thyroiditis (Irvine, 1978;Farid et al., 1981). With the availability of serological reagents for HLA-DR typing, this dichotomy was further emphasized, with reports of a n HLA-DR3 or DR5 association with atrophic thyroiditis (primary myxoedema) and Hashimoto's thyroiditis respectively (Weissel et al., 1980;Farid et al., 19...

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“…Data on HLA haplotypes and their association with HT have been less definitive than those on GD (Vaidya et al 2002). In addition, there are no consistency between the different studies reported on HLA association with HT, such as HLA-DQw7 in English Caucasians (Tandon et al 1991), HLA-DRB1*0405 in Greek population (Kokaraki et al 2009), HLA-DRw53 in Japanese (Honda et al 1989), and HLA-DR9 in Chinese (Hawkins et al 1987). In our study, when the frequencies of HLA DQB1-DQA1 were compared between patients and controls, positive association was found with the haplotypes DQB1*0302-DQA1*0501 (P 00.008, OR 02.378, CI 0 1.241-4.558) and DQB1*0302-DQA1*0301 (P 00.002,OR02.402,.…”

Section: Discussionmentioning

confidence: 99%

Genetics of autoimmune thyroid disease in the Lebanese population

et al. 2012

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This study aims to investigate the association of human leukocyte antigen (HLA) class II genes and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) with autoimmune thyroid diseases in the Lebanese population. A total of 128 patients with autoimmune thyroid disease (55 with Graves' disease (GD) and 73 with Hashimoto's thyroiditis (HT)) were typed for HLA DQA1 (0301 and 0501) and DQB1 (0201, 0302, and 0303) and for 49A/G CTLA-4 using PCR-based sequence-specific priming methods. A total of 186 matched controls were typed for the same alleles and compared to the diseased population. Results showed no significant differences in HLA DQB1*0201 or DQB1*0301 allelic frequencies or CTLA-4 polymorphisms between patients and controls. For GD, there was a weak association with HLA DQB1*0302 [34.6% (19 of 55)

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Strong association between HLA DRw9 and Hashimoto's thyroiditis in Southern Chinese

Abstract: The distribution of HLA-A, -B, and -DR

Cited by 63 publications

References 1 publication

Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation

Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation

Autoimmune thyroiditis: predisposition and pathogenesis

Genetics of autoimmune thyroid disease in the Lebanese population

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