Stromal tumor of the lesser omentum: a case report

Abstract

Gastrointestinal stromal tumors (GISTs) represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein detected by immunohistochemical staining for the CD117 antigen. Extragastrointestinal stromal tumors (EGISTs), neoplasms with immunohistological features overlapping those of GISTs, are found in the abdomen outside of the gastrointestinal tract with no connection to the gastric or intestinal wall. We report the clinical, macroscopic and immunohistological features of an EGIST arising in the lesser omentum of a 58-year-old woman. This is a very rare location of intra abdominal stromal tumors.

Clinicopathological features and prognosis of omental gastrointestinal stromal tumor: evaluation of a pooled case series

“…Literature search of MEDLINE was performed for all articles in English published from 1998 through 2015. MEDLINE search resulted in 47 case reports 8 9 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 including 57 patients and 6 case series 61 62 63 64 65 66 including 40 cases. As a result, a total of 99 omental GISTs patients were identified.…”

Extragastrointestinal stromal tumour of the lesser omentum: A case report and literature review

“…Our case was a woman with an EGIST in the lesser sac. There have been only a few previous reports of such tumours arising in the lesser omentum [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] . The development of omental EGISTs is usually rapid without typical clinical symptoms.…”

“…Extragastrointestinal stromal tumours (EGISTs) are very uncommon compared to their gastrointestinal counterparts and typically are not connected to the walls or serosal surfaces of gastrointestinal tubular organs. Most of them originate from the intestinal mesentery and the omentum but there have been sporadic reports of EGISTs in other sites such as retroperitoneum, liver, hepatobiliary tree, pancreas, spleen, uterus, vagina, inguinal hernia sac, rectovaginal septum, ovary, pleura, pericardium, prostate, urinary bladder, scrotum, seminal vesicles and abdominal wall [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] . Although EGISTs seem to have morphological and immunohistochemical similarities with GISTs, their pathogenesis, incidence, genetic background and prognosis are not completely known because they are extremely rare [6] .…”

Extra-gastrointestinal stromal tumor with a large cyst

“…They usually arise in the stomach (60–70%), small intestine (20–30%), and large intestine (10%) [2]. GISTs arising in sites other than the alimentary tract are called extra-gastrointestinal stromal tumors (EGISTs) and are rarer than GISTs; EGISTs arising in the mesentery and omentum account for approximately 2% and 1% of all GISTs, respectively [3, 4].…”