2013
DOI: 10.1186/1471-2121-14-17
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Stromal fibroblasts in the microenvironment of gastric carcinomas promote tumor metastasis via upregulating TAGLN expression

Abstract: BackgroundFibroblasts play a critical role in tumorigenesis, tumor progression and metastasis. However, their detailed molecular characteristics and clinical significance are still elusive. TAGLN is an actin-binding protein that plays an important role in tumorigenesis.ResultsWe investigated the interaction between cancer cells and the tumor microenvironment to determine how the fibroblasts from human gastric carcinoma facilitate tumorigenesis through TAGLN. QRT-PCR and Western blot indicated that TAGLN expres… Show more

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Cited by 57 publications
(56 citation statements)
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“…Fibroblasts are known to express transgelin (53) and Schwann cells also express transgelin based on our data (Fig. 3C), indicating that two of the major cells forming MPNST tumors, Schwann cells and fibroblasts, express transgelin.…”
Section: Discussionsupporting
confidence: 56%
“…Fibroblasts are known to express transgelin (53) and Schwann cells also express transgelin based on our data (Fig. 3C), indicating that two of the major cells forming MPNST tumors, Schwann cells and fibroblasts, express transgelin.…”
Section: Discussionsupporting
confidence: 56%
“…The ECM proteins secreted by CAFs provide an optimal microenvironment for gastric cancer. Furthermore, a multitude of molecules, including growth, transcription and inflammatory factors, are also highly expressed in CAFs and stimulate the invasion of gastric cancer cells; these include fibroblast growth factor 9 (67), Twist 1 (68), interleukin 22 (69), galectin-1 (70) and transgelin (71). Consequently, CAFs, as important components of stromal cells, secrete numerous molecules that further promote tumourigenesis.…”
Section: Promotion Of Metastasis By Cafmentioning
confidence: 99%
“…Furthermore, the prevalence of CAFs is related to certain clinicopathologic features, such as tumor size and invasive depth, as well as metastasis of gastric carcinoma [13]. Moreover, CAFs could stimulate tumor cell growth, migration and invasion, as well as resistance to chemotherapy [14][15][16].…”
Section: Introductionmentioning
confidence: 99%