Stromal expression of neutrophil gelatinase‐associated lipocalin correlates with poor differentiation and adverse prognosis in oral squamous cell carcinoma

Shinriki, Satoru; Jono, Hirofumi; Ueda, Mitsuharu; Obayashi, Konen; Nakamura, Takuya; Ota, Kazutoshi; Ota, Tomoko; Sueyoshi, Tetsuro; Guo, Jianying; Hayashi, Mitsuhiro; Hiraki, Akimitsu; Nakayama, Hideki; Yamashita, Satoshi; Shinohara, Masanori; Ando, Yumiko

doi:10.1111/his.12293

Cited by 15 publications

(20 citation statements)

References 34 publications

(72 reference statements)

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“…Among the proteins that were found up‐regulated in the saliva from OSCC patients, Hiromoto et al., 2011 also showed that the LCN2 expression was strongly up‐regulated in well‐differentiated OSCC tissues and correlated with poor differentiation and adverse prognosis in oral squamous cell carcinoma . Noorlag et al.…”

Section: Resultsmentioning

confidence: 99%

A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva

et al. 2015

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Head and neck cancers, including oral squamous cell carcinoma (OSCC), are the sixth most common malignancy in the world and are characterized by poor prognosis and a low survival rate. Saliva is oral fluid with intimate contact with OSCC. Besides non-invasive, simple, and rapid to collect, saliva is a potential source of biomarkers. In this study, we build an SRM assay that targets fourteen OSCC candidate biomarker proteins, which were evaluated in a set of clinically-derived saliva samples. Using Skyline software package, we demonstrated a statistically significant higher abundance of the C1R, LCN2, SLPI, FAM49B, TAGLN2, CFB, C3, C4B, LRG1, SERPINA1 candidate biomarkers in the saliva of OSCC patients. Furthermore, our study also demonstrated that CFB, C3, C4B, SERPINA1 and LRG1 are associated with the risk of developing OSCC. Overall, this study successfully used targeted proteomics to measure in saliva a panel of biomarker candidates for OSCC.

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Section: Resultsmentioning

confidence: 99%

A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva

et al. 2015

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“…Similar results have been reported by another study in which it was shown by immuno-histochemical examinations that NGAL expression was strongly up-regulated in well-differentiated oral squamous cell carcinoma (OSCC) tissues and moderately to weakly up-regulated in moderately to poorly differentiated OSCC tissues as compared to normal mucosa and leukoplakia showing very weak expressions. Western blot analysis showed positive correlation of NGAL expression levels with cell morphology patterns and loss of E-cadherin[18]. So, NGAL levels may be raised as an effect or cause of tumor.…”

Section: Discussionmentioning

confidence: 99%

Levels of neutrophil gelatinase-assosciated lipocalin in patients with head and neck squamous cell carcinoma in Indian population from Haryana state

Verma¹,

Dahiya²,

Soni³

et al. 2017

WJCO

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AIMTo study the levels of neutrophil gelatinase associated lipocalin (NGAL) in head and neck squamous cell carcinoma (HNSCC).METHODSThis was a non randomized case control study conducted at Department of Biochemistry, in collaboration with Regional Cancer Center over a period of one year. The study population included 50 adult newly diagnosed HNSCC patients reporting in outpatient department at Regional Cancer Center and compared with 50 healthy controls. NGAL was estimated by ELISA technique. Student t test and χ2 test were applied for comparison of means of study groups. Correlations between groups were analyzed using Pearson correlation coefficient (r) formula.RESULTSPatients with HNSCC exhibited significantly increased levels of NGAL (P < 0.05) as compared to healthy controls (978.88 ± 261.39 ng/mL vs 34.83 ± 7.59 ng/mL). Out of 50, 26 patients (52%) were in stage IV, 21 (42%) in stage III, 1 (2%) patient in stage II and 2 (4%) patients were in stage I. Metastasis was absent in 98% patients and mean NGAL levels were highest in these patients but P value was not significant. Mean NGAL levels were highest in stage IV [1041.54 ± 222.15 ng/mL (stage IV) vs 1040 ± 0.00 ng/mL (stage I); 900 ± 0.00 ng/mL (stage II) and 1031.90 ± 202.55 ng/mL (stage III)] and χ2 test was highly significant (P < 0.001). Thirty-six patients (72%) were having moderately differentiated HNSCC and mean NGAL levels were maximum in patients with well differentiated HNSCC (1164 ± 315.64 ng/mL vs 1013.33 ± 161.19 ng/mL in moderately differentiated and 890 ± 11.55 ng/mL in poorly differentiated) and the results were also highly significant (P < 0.001, χ2 test).CONCLUSIONThe present work demonstrates a potential role of NGAL as cancer biomarker and its use in monitoring the HNSCC progression.

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“…Accordingly, higher neutrophil density was associated with lymph node metastasis and recurrence, and poor tumor differentiation . On the other hand, these studies show lack of association between TAN and patient age, tumor location, tumor size, N stage, tumor histological grade, and clinical stage . Thus, there is still no consensus on the clinical and prognostic relevance of TAN for OSCC patients.…”

Section: Introductionmentioning

confidence: 95%

“…For OSCC, studies reported association between high neutrophil to lymphocyte ratio (NLR) and worse prognosis, poor tumor differentiation, and advanced clinical stages . Accordingly, higher neutrophil density was associated with lymph node metastasis and recurrence, and poor tumor differentiation . On the other hand, these studies show lack of association between TAN and patient age, tumor location, tumor size, N stage, tumor histological grade, and clinical stage .…”

Section: Introductionmentioning

confidence: 97%

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Immunophenotype of neutrophils in oral squamous cell carcinoma patients

Caldeira

Vieira

Sousa

et al. 2017

J Oral Pathology Medicine

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The amount and immunophenotype of neutrophils and lymphocytes differ between patients and healthy individuals, with a pro-tumorigenic profile of neutrophils. As these cells also get within tumor microenvironment, they possibly exert systemic and local functions in cancer pathogenesis. The association of neutrophil count with outcome corroborates recent studies and this merits further investigation for applicability as a prognosticator.

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Stromal expression of neutrophil gelatinase‐associated lipocalin correlates with poor differentiation and adverse prognosis in oral squamous cell carcinoma

Cited by 15 publications

References 34 publications

A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva

A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva

Levels of neutrophil gelatinase-assosciated lipocalin in patients with head and neck squamous cell carcinoma in Indian population from Haryana state

Immunophenotype of neutrophils in oral squamous cell carcinoma patients

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