Stromal Cells Responsible for Transferring the Microenvironment of the Hemopoietic Tissues

Friedenstein, A. J.; Chailakhyan, R. K.; Latsinik, N. V.; Panasyuk, A. F.; Keiliss-Borok, Iren V.

doi:10.1097/00007890-197404000-00001

Cited by 1,294 publications

(769 citation statements)

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“…Bone marrow (BM) contains rare cells of non-hematopoietic origin (representing 0.01-0.001% of total BM cells) [1] capable of differentiating into cells of mesodermal lineage including osteoblasts, adipocytes, and chondrocytes [1,2]. These cells constitute the stromal trabecular scaffold which, close to the endosteum, tightly interacts with hematopoietic stem cells (HSC) [3].…”

Section: Introductionmentioning

confidence: 99%

Immunoregulatory function of mesenchymal stem cells

2006

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Mesenchymal stem cells (MSC) are a rare subset of stem cells residing in the bone marrow where they closely interact with hematopoietic stem cells and support their growth and differentiation. MSC can differentiate into multiple mesenchymal and non‐mesenchymal lineages, providing a promising tool for tissue repair. In addition, MSC suppress many T cell, B cell and NK cell functions and may affect also dendritic cell activities. Due to their limited immunogenicity, MSC are poorly recognized by HLA‐incompatible hosts. Based on these unique properties, MSC are currently under investigation for their possible use to treat immuno‐mediated diseases. However, both their condition of immunoprivilege and their immunosuppressive function have recently been challenged when analyzed under particular experimental conditions. Thus, it is likely that MSC effects on the immune system may be deeply influenced not only by cell‐to‐cell interactions, but also by environmental factors shaping their phenotype and functions.

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Section: Introductionmentioning

confidence: 99%

Immunoregulatory function of mesenchymal stem cells

2006

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“…Mesenchymal stromal cells (MSCs), originally isolated from adult bone marrow (BM), are multipotent cells that provide stromal micro-environmental support for hematopoietic stem cells (HSCs); as well as give rise to mesodermal tissues such as bone, fat and cartilage [1][2][3][4]. Over the last several years MSCs have been derived from a variety of other tissues of adult [5][6][7] or fetal origin [8,9].…”

Section: Introductionmentioning

confidence: 99%

Derivation and immunological characterization of mesenchymal stromal cells from human embryonic stem cells

Trivedi

Hematti

2008

Experimental Hematology

177

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Objective-We have previously shown the simultaneous generation of CD73+ mesenchymal stromal cells (MSCs) along with CD34+ hematopoietic cells from human embryonic stem cells (ESCs) when they are co-cultured with OP9 murine stromal cells. We investigated whether MSCs can be derived from human ESCs without co-culturing with OP9 cells, and if such cells exhibit immunological properties similar to MSCs derived from adult human bone marrow (BM).Materials and Methods-Our starting populations were undifferentiated ESCs cultured on matrigel-coated plates without feeder cells. The differentiated fibroblast-looking cells were tested for expression of MSC markers and their potential for multi-lineage differentiation. We investigated surface expression of HLA molecules on these MSCs before and after treatment with interferon gamma (IFN-γ). We also tested the proliferative response of T-lymphocytes towards MSCs and the effects of MSCs in mixed lymphocyte reaction (MLR) assays. Conclusions-MSCs can be derived from human ESCs without feeder cells. These human ESCderived MSCs have cell surface markers, differentiation potentials, and immunological properties in vitro that are similar to adult BM-derived MSCs. Results-We

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“…This review summarizes the current knowledge about the MSCs derived from most investigated bone marrow tissue and other unconventional tissues in the treatment of MS. Friedenstein et al (1974) in 1968 described first the MSCs as the fibroblast-like cells in the bone marrow. Subsequent studies showed that although MSCs reside mainly in bone marrow, they can be isolated also from other adult and fetal tissues including adipose tissue, umbilical cord, fetal lung, amniotic fluid, placenta, synovial membranes, peripheral blood, and dental pulp (Erices et al 2002;Campagnoli et al 2001;De Bari et al 2001;Int Anker et al 2004;Wagner et al 2005;Huang et al 2009;Ab Kadir et al 2012).…”

Section: Introductionmentioning

confidence: 99%