Stromal cells from term fetal membrane are highly suppressive in allogeneic settings <i>in vitro</i>

Karlsson, Helén; Erkers, Tom; Nava, Stefano; Ruhm, S.; Westgren, Magnus; Ringdén, Olle

doi:10.1111/j.1365-2249.2011.04540.x

Cited by 93 publications

(117 citation statements)

References 51 publications

(73 reference statements)

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“…90 We first compared three different sources of cells from the placenta: DSCs, stromal cells from umbilical cord and stromal cells from placental villi in vitro. 6 We found that DSCs exerted the most consistent inhibition of proliferation and inhibition of IFN-g and IL-17 production in mixed lymphocyte reactions compared with BM-MSCs and the other sources of stromal cells from placenta. Other major advantages with this cell population are the great expansion potential at low passage and high expression of integrins.…”

Section: Alternate Sources Of Cells For Acute Gvhdmentioning

confidence: 85%

“…5,10,11,46,47 This anti-proliferative ability is shared by all stromal cells, including placental stromal cells 6 and skin fibroblasts. 7 Despite the fact that MSCs reduce alloreactivity in vitro, it has been difficult to correlate clinical outcome to successful inhibition of mixed lymphocyte reactions with BMMSCs and patient PBMCs as responder cells.…”

Section: Immune Modulation By Mscsmentioning

confidence: 99%

“…Other major advantages with this cell population are the great expansion potential at low passage and high expression of integrins. 6,52 We therefore used DSCs for treatment of severe steroid-refractory acute GVHD of grades III-IV in nine patients. 90 Median age was 57 years and two patients had a complete response and four had a partial response.…”

Section: Alternate Sources Of Cells For Acute Gvhdmentioning

confidence: 99%

“…It is often stated that MSCs are immunoprivileged, and are unable to induce alloresponses, 10,11 but stromal cells constitutively express MHC class I, and do indeed induce proliferation of allogeneic lymphocytes. 6 Beggs et al 12 showed that baboons produced alloantibodies after administration of allogeneic BM-MSCs, indicating that they can immunize the host. Furthermore, allogeneic BM-MSCs are rejected in MHC-mismatched murine recipients 13 and they can induce memory T-cell responses, resulting in the rejection of allogeneic stem cell grafts.…”

Section: Introductionmentioning

confidence: 99%

“…2 DSCs are also important for the development of feto-maternal tolerance. 3,4 Stromal cells have immunosuppressive capacity, [5][6][7] which paved the way for using them in the treatment of inflammatory diseases. Owing to their low immunostimulatory effect, allogeneic third-party stromal cells are often used.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Stromal cells–are they really useful for GVHD?

Kaipe

Erkers

Sadeghi

et al. 2014

Bone Marrow Transplant

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Mesenchymal stromal cells (MSCs) have immunomodulatory effects and are increasingly being used for the treatment of acute and chronic GVHD. Although they seem immuno-privileged, they induce alloresponses, but the risk of immunization is poorly characterized. After infusion, they first reach the lungs, liver and spleen, and are then difficult to trace. Several mechanisms are involved in stromal cells suppressing alloreactivity, such as induction of regulatory T cells, but whether or not this will also affect leukemic relapse or increase infections is not known. Although several encouraging pilot studies have been published, there have been few prospective randomized trials. There may be a bias in the literature, as negative results are seldom published, and there have been few comparative studies with other immunosuppressive regimens. Most animal models have failed to show any effect on GVHD. Several questions remain to be answered for optimization of stromal cell therapy. Which source is optimal-BM, fat, cord or decidua? Can stromal cells be replaced by exosomes, which culture conditions are most appropriate and at what passage and how frequently should cells be administered? More research is required to move stromal cell therapy forward to become an established treatment for acute and chronic GVHD.

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Section: Alternate Sources Of Cells For Acute Gvhdmentioning

confidence: 85%

Section: Immune Modulation By Mscsmentioning

confidence: 99%

Section: Alternate Sources Of Cells For Acute Gvhdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Stromal cells–are they really useful for GVHD?

Kaipe

Erkers

Sadeghi

et al. 2014

Bone Marrow Transplant

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Newborn Stem Cells: Identity, Function, and Clinical Potential

Park

Chan²,

Gohel

et al. 2013

Perinatal Stem Cells

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The Molecular Mechanisms Through Which Placental Mesenchymal Stem Cell‐Derived Extracellular Vesicles Promote Myelin Regeneration

et al. 2022

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Multiple sclerosis (MS) is a debilitating degenerative disease characterized by an immunological attack on the myelin sheath leading to demyelination and axon degeneration. Mesenchymal stem/stromal cells (MSCs) and secreted extracellular vesicles (EVs) have become attractive targets as therapies to treat neurodegenerative diseases such as MS due to their potent immunomodulatory and regenerative properties. The placenta is a unique source of MSCs (PMSCs), demonstrates "fetomaternal" tolerance during pregnancy, and serves as a novel source of MSCs for the treatment of neurodegenerative diseases. PMSCs and PMSC-EVs have been shown to promote remyelination in animal models of MS, however, the molecular mechanisms by which modulation of autoimmunity and promotion of myelination occurs have not been well elucidated. The current review will address the molecular mechanisms by which PMSC-EVs can promote remyelination in MS.

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Stromal cells from term fetal membrane are highly suppressive in allogeneic settings in vitro

Cited by 93 publications

References 51 publications

Stromal cells–are they really useful for GVHD?

Stromal cells–are they really useful for GVHD?

Newborn Stem Cells: Identity, Function, and Clinical Potential

The Molecular Mechanisms Through Which Placental Mesenchymal Stem Cell‐Derived Extracellular Vesicles Promote Myelin Regeneration

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