Stromal cell regulation of homeostatic and inflammatory lymphoid organogenesis

Kain, Matthew J. W.; Owens, Benjamin M. J.

doi:10.1111/imm.12119

Cited by 25 publications

(22 citation statements)

References 129 publications

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“…Contrary to mouse FDCs [45], CD21 hi “FDC-like” cells that we detected by flow cytometry expressed CD31. This expression was confirmed in our immunofluorescent analyses on tissue cross-sections since gp38, CD21 (hallmark of FDCs), and CD31 co-localized in FDC-rich zones in ATLOs (Figure 1B, insets N°3 and N°8), thus confirming that FDCs were positive for CD31.…”

Section: Discussioncontrasting

confidence: 72%

Deciphering the Stromal and Hematopoietic Cell Network of the Adventitia from Non-Aneurysmal and Aneurysmal Human Aorta

et al. 2014

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Aneurysm is associated to a complex remodeling of arteries that affects all their layers. Although events taking place in the intima and the media have received a particular attention, molecular and cellular events taking place in the adventitia have started to be deciphered only recently. In this study, we have precisely described the composition and distribution of stromal and hematopoietic cells in human arterial adventitia, both at steady state and in the setting of aortic aneurysm. Using polychromatic immunofluorescent and flow cytometry analyses, we observed that unlike the medial layer (which comprises mostly macrophages and T cells among leukocytes), the adventitia comprises a much greater variety of leukocytes. We observed an altered balance in macrophages subsets in favor of M2-like macrophages, an increased proliferation of macrophages, a greater number of all stromal cells in aneurysmal aortas. We also confirmed that in this pathological setting, adventitia comprised blood vessels and arterial tertiary lymphoid organs (ATLOs), which contained also M-DC8+ dendritic cells (slanDCs) that could participate in the induction of T-cell responses. Finally, we showed that lymphatic vessels can be detected in aneurysmal adventitia, the functionality of which will have to be evaluated in future studies. All together, these observations provide an integrative outlook of the stromal and hematopoietic cell network of the human adventitia both at steady state and in the context of aneurysm.

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Section: Discussioncontrasting

confidence: 72%

Deciphering the Stromal and Hematopoietic Cell Network of the Adventitia from Non-Aneurysmal and Aneurysmal Human Aorta

et al. 2014

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“…The developmental origin and phenotypic heterogeneity of stromal cells in TLTs have not been clarified due to the limitation of in vivo models (25,26). Most in vivo TLT models are organ-specific transgenic mouse models ectopically expressing molecules stimulating TLT formation, which are artificial and incapable of fully mimicking the pathophysiology of TLTs.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Sato¹,

et al. 2016

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“…Lymphoid tissue inducer cells interact with cells of mesenchymal origin, called lymphoid tissue organizer cells, which produce chemokines that in turn induce more LTαβ. The role of stromal cells in SLO development and maintenance is becoming better understood (10) as is the response of these cells to neuronal signals, including retinoic acid (11). HEVs are also key organizers of LN development (12), in that they express LTβR (13), respond to LTαβ (14,15), and present chemokines and adhesion molecules…”

Section: Slosmentioning

confidence: 99%