Stromal Cell-Derived Factor-1/CXCR4 Signaling Modifies the Capillary-Like Organization of Human Embryonic Stem Cell-Derived Endothelium In Vitro

Chen, Tong; Bai, Hao; Shao, Ying; Arzigian, Melanie; Janzen, Viktor; Attar, Eyal C.; Xie, Yi; Scadden, David T.; Wang, Zack Z.

doi:10.1634/stemcells.2006-0145

Cited by 81 publications

(84 citation statements)

References 65 publications

(87 reference statements)

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“…A further interesting phenotype identified in SDF-1/CXCR4 knockout mice is a deficiency in blood vessel development, initially observed in the gastrointestinal system (Tachibana et al, 1998). Consistent with such observations, CXCR4 receptors have been shown to be expressed by hemangioblasts, the earliest common precursor to hematopoietic and endothelial stem cells found in yolk sac blood islands (McLeod et al, 2006) and also by endothelial cells that can be derived from embryonic stem cells (ESCs) in culture (Chen et al, 2007). In the latter case these endothelial cells expressed CXCR4 and migrated towards an SDF-1 gradient.…”

Section: Development Of Non Neuronal Tissuesmentioning

confidence: 69%

CXCR4 signaling in the regulation of stem cell migration and development

Miller¹,

Banisadr²,

Bhattacharyya³

2008

Journal of Neuroimmunology

151

125

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The regulated migration of stem cells is a feature of the development of all tissues and also of a number of pathologies. In the former situation the migration of stem cells over large distances is required for the correct formation of the embryo. In addition, stem cells are deposited in niche like regions in adult tissues where they can be called upon for tissue regeneration and repair. The migration of cancer stem cells is a feature of the metastatic nature of this disease. In this article we discuss observations that have demonstrated the important role of chemokine signaling in the regulation of stem cell migration in both normal and pathological situations. It has been demonstrated that the chemokine receptor CXCR4 is expressed in numerous types of embryonic and adult stem cells and the chemokine SDF-1/CXCL12 has chemoattractant effects on these cells. Animals in which SDF-1/CXCR4 signaling has been interrupted exhibit numerous phenotypes that can be explained as resulting from inhibition of SDF-1 mediated chemoattraction of stem cells. Hence, CXCR4 signaling is a key element in understanding the functions of stem cells in normal development and in diverse pathological situations.

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Section: Development Of Non Neuronal Tissuesmentioning

confidence: 69%

CXCR4 signaling in the regulation of stem cell migration and development

Miller¹,

Banisadr²,

Bhattacharyya³

2008

Journal of Neuroimmunology

151

125

View full text Add to dashboard Cite

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“…At similar stages the expression profile of CXCR4 has now shifted to the neural tube as described before (Yusuf et al, 2005;McGrath et al, 1999). The role of SDF-1 has been well investigated in endothelial cell organization and vessel formation (Chen et al, 2007). Recently SDF-1 has also been advocated as a probable candidate for therapeutic neovascularization (Zhou et al, 2007).…”

Section: Discussionmentioning

confidence: 94%

Stromal-derived factor-1 (SDF-1) expression during early chick development

Rehimi¹,

Khalida²,

Yusuf³

et al. 2008

Int. J. Dev. Biol.

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Cell migration plays a fundamental role in a wide variety of biological processes including development, tissue repair and disease. These processes depend on directed cell migration along and through cell layers. Chemokines are small secretory proteins that exert their effects by activating a family of G-protein coupled receptors and have been shown to play numerous fundamental roles in the control of physiological and pathological processes during development and in adult tissues, respectively. Stromal-derived factor-1 (SDF-1/CXCL12), a ligand of the chemokine receptor, CXCR4, is involved in providing cells with directional cues as well as in controlling their proliferation and differentiation. Here we studied the expression pattern of SDF-1 in the developing chick embryo. We could detect a specific expression of SDF-1 in the ectoderm, the sclerotome, the intersomitic spaces and the developing limbs. The expression domains of SDF-1 reflect its role in somitic precursor migration and vessel formation in the limbs.

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“…It has been demonstrated that SDF-1 and CXCR4 are expressed concurrently with human ESC-derived embryonic endothelial differentiation and that human ESC-derived embryonic ECs undergoes dose-dependent chemotaxis to SDF-1, which enhances vascular network formation in Matrigel. 41 No principal differences are described for the regulation of angioblast migration by the repulsive and chemoattractant factors in the different species and models. 25,34 -41…”

Section: Additional Repulsive and Attracting Factorsmentioning

confidence: 99%