Stromal Cell–Derived Factor-1/Chemokine (C-X-C Motif) Ligand 12 Stimulates Human Hepatoma Cell Growth, Migration, and Invasion

Abstract

In addition to their physiologic effects in inflammation and angiogenesis, chemokines are involved in cancer pathology. The aim of this study was to determine whether the chemokine stromal cell -derived factor 1 (SDF-1) induces the growth, migration, and invasion of human hepatoma cells. We show that SDF-1 G protein -coupled receptor, chemokine

Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis

“…Recently, our team showed that SDF-1 stimulates human hepatoma cell growth, migration and invasion, with data obtained in human liver biopsy specimens confirming in vitro findings [15] . The homozygous (G to A) mutation at position 801 of the 3'-untranslated region of the SDF-1 gene, SDF-1 3'A has been linked to delayed progression to AIDS in adults with HIV-1 infection [16] , but its influence in the course of HCV infection is still unknown.…”

SDF1 induction by acidosis from principal cells regulates intercalated cell subtype distribution

“…While, in principle, many mechanisms might be invoked to mediate this critical homeostatic response, it is clear that the machinery for regulation (Figure 1), it is likely that it was produced by the principal cell. SDF1 is poorly diffusible and tightly binds to a variety of extracellular matrix proteins (15).…”

Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells

“…In fact, one of the most widely recognized receptor/ligand pairs for HSC trafficking is CXCR4/CXCL12 (SDF1); in addition, CXCR4/ SDF1 appears important in dictating migration of several tumor cell lines to metastatic sites. 41,42 However, in contrast to the key role of CXCR4/SDF1 in HSC migration, a recent publication by Ip and co-workers showed blocking of the CXCR4 receptor had no impact on MSC migration, suggesting key differences between the migration signals of these two stem cells. 43 This controversial receptor indicates that receptor function differs between cell types and enhances the importance of examining receptors found mutually expressed on MSC-and HSC-like CXCR4, CCR5 44 and VEGFR.…”