Stroke treatment: Is exosome therapy superior to stem cell therapy?

Cai, Yichen; Liu, Wanying; Lian, Lu; Xu, Ying-Zhi; Bai, Xiaodan; Xu, Shixin; Zhang, Junping

doi:10.1016/j.biochi.2020.09.025

Cited by 49 publications

(38 citation statements)

References 127 publications

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“…Recent studies showed promising applications of such EVs due to their cargo specificity, built on EVs’ secreted cell origin [ 196 ]. These nanovesicles can go through various biological barriers, including the blood-brain barrier; further, their cargo is well preserved and protected from degradation [ 197 ]. In comparison with stem cell therapy, EVs reduce the risk of immunogenicity, tumorigenesis, avoid cell differentiation to unexpected derivation.…”

Section: Therapeutical Application Of Extracellular Vesicles For Skin Wound Healingmentioning

confidence: 99%

Extracellular Vesicles in Skin Wound Healing

et al. 2021

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Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Such an extensive involvement of EVs suggests exploiting their action to modulate the impaired healing phase. Furthermore, next to their natural wound healing capacity, EVs can be engineered for better defined pharmaceutical purposes, such as carrying specific cargo or targeting specific destinations by labelling them with certain surface proteins. This review aims to promote scientific awareness in basic and translational research of EVs by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration, and treatment of dermal diseases, including the stem cell-derived, plant-derived, and engineered EVs.

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Section: Therapeutical Application Of Extracellular Vesicles For Skin Wound Healingmentioning

confidence: 99%

Extracellular Vesicles in Skin Wound Healing

et al. 2021

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“…Recently, treatment strategies based on exosomes of MSCs have been widely reported in many diseases. The potential mechanism of exosomes treatment in the ICH mainly comprises the anti-apoptotic, neurogenesis, angiogenesis, and anti-inflammation effects through its miRNAs (Cai et al, 2020;Duan et al, 2020).…”

Section: Exosomes Therapiesmentioning

confidence: 99%

Mesenchymal Stem Cells Transplantation in Intracerebral Hemorrhage: Application and Challenges

Gong

Hao

Wang

2021

Front. Cell. Neurosci.

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Intracerebral hemorrhage (ICH) is one of the leading causes of death and long-term disability worldwide. Mesenchymal stem cell (MSC) therapies have demonstrated improved outcomes for treating ICH-induced neuronal defects, and the neural network reconstruction and neurological function recovery were enhanced in rodent ICH models through the mechanisms of neurogenesis, angiogenesis, anti-inflammation, and anti-apoptosis. However, many key issues associated with the survival, differentiation, and safety of grafted MSCs after ICH remain to be resolved, which hinder the clinical translation of MSC therapy. Herein, we reviewed an overview of the research status of MSC transplantation after ICH in different species including rodents, swine, monkey, and human, and the challenges for MSC-mediated ICH recovery from pathological microenvironment have been summarized. Furthermore, some efficient strategies for the outcome improvement of MSC transplantation were proposed.

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“…Finally, cell survival is not always required to achieve functional recovery of a specific organ, suggesting that a temporary paracrine effect is sufficient to stimulate endogenous regeneration in organs that retained this potency. This is shown in the case of ischemic hearts or through the action of MSCs in acute myocardial infarction, burned skins, liver or traumatic brain injuries and many other diseases [114,[131][132][133][134]. Such observations raise the question of whether cell-derived products may be sufficient for a therapeutic improvement in some specific disease conditions.…”

Section: Limitations/challengesmentioning

confidence: 99%

The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles

Jarrige

Frank

Herardot

et al. 2021

Cells

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The rapid progress in the field of stem cell research has laid strong foundations for their use in regenerative medicine applications of injured or diseased tissues. Growing evidences indicate that some observed therapeutic outcomes of stem cell-based therapy are due to paracrine effects rather than long-term engraftment and survival of transplanted cells. Given their ability to cross biological barriers and mediate intercellular information transfer of bioactive molecules, extracellular vesicles are being explored as potential cell-free therapeutic agents. In this review, we first discuss the state of the art of regenerative medicine and its current limitations and challenges, with particular attention on pluripotent stem cell-derived products to repair organs like the eye, heart, skeletal muscle and skin. We then focus on emerging beneficial roles of extracellular vesicles to alleviate these pathological conditions and address hurdles and operational issues of this acellular strategy. Finally, we discuss future directions and examine how careful integration of different approaches presented in this review could help to potentiate therapeutic results in preclinical models and their good manufacturing practice (GMP) implementation for future clinical trials.

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Stroke treatment: Is exosome therapy superior to stem cell therapy?

Cited by 49 publications

References 127 publications

Extracellular Vesicles in Skin Wound Healing

Extracellular Vesicles in Skin Wound Healing

Mesenchymal Stem Cells Transplantation in Intracerebral Hemorrhage: Application and Challenges

The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles

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