Stroke secondary to leptomeningeal carcinomatosis with radiologic signs of arterial invasion

Abstract

Background: Compared to the general population, cancer patients are more likely to suffer from cerebral ischemia, either caused by the tumor itself or by the treatments applied. Case Description: We hereby present the clinical case of a patient treated for lung adenocarcinoma, who, years later, developed a case of the right frontal-temporal-insular ischemia secondary to leptomeningeal spread of the primary neoplasm, with an invasion of the walls of the right-middle cerebral artery and its branches. Conclusion: This should be considered an extremely rare form of recurrence of a primary solid tumor with clinical and radiological features that can mimic those of vascular inflammatory entities.

Ischemic Stroke in Cancer: Mechanisms, Biomarkers, and Implications for Treatment

“…52,53 Leptomeningeal carcinomatosis can trigger cerebral ischemia through invasion of perivascular spaces by neoplastic cells, followed by vessel wall infiltration, or induced vasospasm. 54,55 Malignant hematologic tumors, such as intravascular lymphoma, can directly obstruct blood vessels. 24,56,57 Additionally, accumulating evidence suggests that cancer is a risk factor for atrial fibrillation, likely due to shared risk factors and increased inflammation that may link cancer to left atrial cardiomyopathy.…”

“…52 53 Leptomeningeal carcinomatosis can trigger cerebral ischemia through invasion of perivascular spaces by neoplastic cells, followed by vessel wall infiltration, or induced vasospasm. 54 55 Malignant hematologic tumors, such as intravascular lymphoma, can directly obstruct blood vessels. 24 56 57…”