Stroke risk in multiple sclerosis: a critical appraisal of the literature

Doskas, Triantafyllos; Dardiotis, Efthimios; Vavougios, George D.; Ntoskas, Konstantinos T.; Sionidou, Pinelopi; Vadikolias, Κonstantinos

doi:10.1080/00207454.2022.2056459

Cited by 3 publications

(2 citation statements)

References 365 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the most pertinent contributors to stroke risk in patients with MS, however, is the chronic inflammatory state 19 . In MS, the classic demyelinated lesions are filled with CD4+ T cells, CD8+ T cells, and plasma cells, demonstrating an active and continuous pro-inflammatory environment (reviewed in Lopes Pinheiero et al 3 ).…”

Section: Risk Of Ischemic Stroke Due To Neuroinflammation In the Sett...mentioning

confidence: 99%

Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review

et al. 2023

View full text Add to dashboard Cite

The immense neuroinflammation induced by multiple sclerosis (MS) promotes a favorable environment for ischemic stroke (IS) development, making IS a deadly complication of MS. The overlapping inflammation in MS and IS is a prelude to the vascular pathology, and an inherent cell death mechanism that exacerbates neurovascular unit (NVU) impairment in the disease progression. Despite this consequence, no therapies focus on reducing IS incidence in patients with MS. To this end, the preclinical and clinical evidence we review here argues for cell-based regenerative medicine that will augment the NVU dysfunction and inflammation to ameliorate IS risk.

show abstract

Section: Risk Of Ischemic Stroke Due To Neuroinflammation In the Sett...mentioning

confidence: 99%

Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The definition of VaD and vascular cognitive impairment (VCI) has evolved over time [ 34 , 62 , 63 , 64 , 65 , 66 ], though overall requires that the cognitive impairment be temporally related to strokes or be accompanied by significant neuroimaging evidence of cerebrovascular disease. PwMS have an increased risk of stroke [ 67 , 68 ], and would thus be more susceptible to developing VCI in addition to MS-related cognitive decline. Among the subtypes of vascular dementia, subcortical vascular dementia due to small-vessel disease [ 69 ] can present with progressive fronto-subcortical dysfunction (e.g., slowed psychomotor speed, impaired executive function, and impaired memory recall, but preserved recognition), similar to subcortical dementia as a result of MS [ 70 ].…”

Section: Dementia and Ms: Can Older Pwms Develop Dementia Or Other Ne...mentioning

confidence: 99%

Cognitive Decline in Older People with Multiple Sclerosis—A Narrative Review of the Literature

et al. 2022

View full text Add to dashboard Cite

Several important questions regarding cognitive aging and dementia in older people with multiple sclerosis (PwMS) are the focus of this narrative review: Do older PwMS have worse cognitive decline compared to older people without MS? Can older PwMS develop dementia or other neurodegenerative diseases such as Alzheimer’s disease (AD) that may be accelerated due to MS? Are there any potential biomarkers that can help to determine the etiology of cognitive decline in older PwMS? What are the neural and cellular bases of cognitive aging and neurodegeneration in MS? Current evidence suggests that cognitive impairment in MS is distinguishable from that due to other neurodegenerative diseases, although older PwMS may present with accelerated cognitive decline. While dementia is prevalent in PwMS, there is currently no consensus on defining it. Cerebrospinal fluid and imaging biomarkers have the potential to identify disease processes linked to MS and other comorbidities—such as AD and vascular disease—in older PwMS, although more research is required. In conclusion, one should be aware that multiple underlying pathologies can coexist in older PwMS and cause cognitive decline. Future basic and clinical research will need to consider these complex factors to better understand the underlying pathophysiology, and to improve diagnostic accuracy.

show abstract

Cross-Prevalence of Multiple Sclerosis and Stroke Evaluated on Cohorts of Four Independent Specialty Medical Centers

Berkovich,

Sokolov,

Totolyan

et al. 2024

Multiple Sclerosis and Related Disorders

View full text Add to dashboard Cite

Stroke risk in multiple sclerosis: a critical appraisal of the literature

Cited by 3 publications

References 365 publications

Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review

Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review

Cognitive Decline in Older People with Multiple Sclerosis—A Narrative Review of the Literature

Cross-Prevalence of Multiple Sclerosis and Stroke Evaluated on Cohorts of Four Independent Specialty Medical Centers

Contact Info

Product

Resources

About