Stroke in patients with cancer

Cestari, Dean M.; Weine, Douglas M.; Panageas, K.; Segal, Alan Z.; DeAngelis, Lisa M.

doi:10.1212/01.wnl.0000129912.56486.2b

Cited by 334 publications

(282 citation statements)

References 35 publications

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“…In a narrow sense, TS was considered to induce strokes due to hypercoagulability, and to have a poor prognosis (8). It has been reported that patients with lung, prostate, breast or ovarian carcinoma, or malignant hematological diseases, tend to suffer from cerebral infarction more frequently compared with patients with other malignant diseases (9).…”

Section: Discussionmentioning

confidence: 99%

Case series of cerebral infarction with Trousseau's syndrome associated with malignant gynecological tumors

Ishikawa

Nakayama

Ishibashi

et al. 2016

Molecular and Clinical Oncology

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Abstract. The association between neoplastic disease and thromboembolic disorders was first recognized by Trousseau in 1865. Blood coagulation abnormalities have been reported in the majority of patients with cancer, including those with ovarian carcinoma. However, Trousseau's syndrome (TS) has rarely been reported in women with ovarian carcinoma. We herein report a case series of TS, notably in the brain, in association with gynecological malignant disease, and emphasize the difficulties associated with the management of these thromboembolic effects. The aim of this study was to present our experience with 5 TS patients whose condition was effectively controlled through treatment of the primary malignant disease. Therefore, we suggest that patients with TS may be cured by tumor resection, even if they have severe thromboembolic disease, such as cerebral or pulmonary infarction.

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Section: Discussionmentioning

confidence: 99%

Case series of cerebral infarction with Trousseau's syndrome associated with malignant gynecological tumors

Ishikawa

Nakayama

Ishibashi

et al. 2016

Molecular and Clinical Oncology

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“…En studie av 96 kreftpasienter med verifisert hjerneinfarkt viste at lungekreft var den dominerende krefttypen (30 %), etterfulgt av primaer hjernekreft (9 %) og prostatakreft (9 %) (6). Pasientene hadde en median overlevelsestid på 4,5 måneder etter hjerneinfarktet (6).…”

Section: Diskusjonunclassified

“…Pasientene hadde en median overlevelsestid på 4,5 måneder etter hjerneinfarktet (6). En prospektiv studie av 842 pasienter med dyp venetrombose behandlet med antikoagulasjon (lavmolekylaert heparin etterfulgt av warfarin) inkluderte 181 individer med kjent kreftsykdom.…”

Section: Diskusjonunclassified

En kvinne med tilbakevendende arteriovenøse tromboser

Jusufovic¹,

Thomassen²,

Storstein³

et al. 2011

Tidsskriftet

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Noe å laere avEn kvinne med tilbakevendende arteriovenøse tromboser1 En 61 år gammel kvinne fikk brystsmerter og forbigående synstap, deretter vansker med bruk av høyre arm og taleforstyrrelser. Tilbakevendende arteriovenøse tromboser gjorde henne i løpet av fem måneder til en dement og pleietrengende pasient. (fig 1a, fig 1b).Iskemiske lesjoner i flere cerebrale kargebet er en sterk indikator på embolisk årsak. Cerebralt infarkt som skyldes embolisering fra hjertet til hjernen utgjør om lag ett av fire hjerneinfarkter. Potensielle årsaker til kardiale embolier er atrieflimmer og atrieflutter, myokardskade etter hjerteinfarkt, dilatert kardiomyopati, endokarditt, myokarditt, mekaniske klaffeproteser, atrieseptumpatologi og intrakardiale svulster. Vår pasient hadde feber, økt CRP og EKG-forandringer, noe som ga mistanke om endokarditt. Endokarditt er en bakteriell infeksjon på hjerteklaffene som kan gi tromber til hjernen og andre organer. Hovedkriteriene for diagnosen endokarditt er to positive blodkulturer med typiske mikroorganismer og karakteristiske ekkokardiografiske funn.

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“…Las causas del infarto cerebral son las mismas que en los pacientes sin cáncer pero se añaden algunos factores específi-cos asociados al cáncer como el estado de hipercoagulabilidad y el tratamiento, ya que tanto la quimioterapia como la radioterapia pueden predisponer a trombosis arteriales o venosas (16) . Dentro de los tratamientos específicos podemos destacar por su importante aumento del riesgo el tamoxifeno (17) , utilizado en el cáncer de mama hormono sensible, y los antiangiogénicos, como el bevacizumab (18) .…”

Section: Accidentes Cerebrovascularesunclassified

Complicaciones neurológicas del paciente con cáncer

López¹,

Valle²,

Ferrer³

et al. 2011

Psicooncología

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ResumenLos avances de las últimas décadas tanto en el diagnóstico como en tratamiento del cáncer han conseguido aumentar la supervivencia, lo que ha conllevado un aumento de las complicaciones neurológicas. Estas complicaciones pueden ser debidas tanto al propio cáncer como al tratamiento y en ocasiones son la primera manifestación de la enfermedad oncológica. Algunas de estas complicaciones son potencialmente reversibles por ello el diagnóstico precoz y su tratamiento correcto pueden mejorar los síntomas neurológicos y la calidad de vida de estos pacientes. En el presente artículo haremos una revisión de las principales complicaciones neurológicas del paciente con cáncer con una orientación diagnóstica y terapéutica.Palabras clave: Cáncer, complicación, neurología, síndrome, paraneoplásico, quimioterapia, radioterapia. AbstractThe advances of recent decades in the diagnosis and treatment of cancer have managed to increase survival, but this has produced an increase in neurological complications. These complications can be caused by cancer and its treatment and sometimes can be the first manifestation of cancer disease. Some of these complications are potentially reversible so that early diagnosis and proper treatment can improve the neurological symptoms and quality of life of these patients. In this article we will review major neurological complications of cancer patients and also do a diagnostic and therapeutic orientation.

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Stroke in patients with cancer

Abstract: Embolic strokes are the commonest cause of stroke in patients with cancer, due partially to hypercoagulability, whereas atherosclerosis accounted for only 22% of stroke in this population. Outcome was primarily determined by the underlying malignancy and the patient's neurologic condition.

Cited by 334 publications

References 35 publications

Case series of cerebral infarction with Trousseau's syndrome associated with malignant gynecological tumors

Case series of cerebral infarction with Trousseau's syndrome associated with malignant gynecological tumors

En kvinne med tilbakevendende arteriovenøse tromboser

Complicaciones neurológicas del paciente con cáncer

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